Human pancreatic growth hormone-releasing hormone-(1-44) stimulates the release of luteinizing hormone, follicle-stimulating hormone and dynorphin

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S26-S27
Author(s):  
W. KNEPEL ◽  
M. SCHWANINGER ◽  
K. D. DÖHLER
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Pancreatic Growth ◽  
Stimulating Hormone

EFFECT OF SYNTHETIC LUTEINIZING HORMONE-AND FOLLICLE STIMULATING HORMONE-RELEASING HORMONE (LH/FSH-RH) ON SERUM LEVELS OF LH, FSH, THYROTROPHIN (TSH) AND GROWTH HORMONE (HGH) IN NORMAL MALE SUBJECTS

1973 ◽  
Vol 73 (3) ◽  
pp. 465-474 ◽  
Author(s):  
Egil Haug ◽  
Peter Torjesen
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Normal Male ◽  
Serum Growth Hormone ◽  
Maximum Serum ◽  
Releasing Hormone ◽  
Serum Lh ◽  
Male Subjects ◽  
Stimulating Hormone

ABSTRACT Four normal male subjects received iv injections of synthetic luteinizing hormone- and follicle stimulating hormone-releasing hormone (LH/FSH-RH) in doses of 12.5, 25, 100, 200 and 400 μg, respectively. A dose of 12.5 μg of LH/FSH-RH caused a significant increase in serum FSH, and 25 μg significantly increased the serum LH. The peak responses occurred 15 to 30 min after the LH/FSH-RH injections in most of the experiments. The increase in the mean maximum serum LH and FSH levels was 2 to 4 fold. There was great variation in response between the subjects, but when tested repeatedly with the same dose of LH/FSH-RH a given individual responded in a consistent manner. The log dose-response curve between LH/FSH-RH and serum LH, and between LH/FSH-RH and serum FSH was approximately linear. A small but significant (P < 0.05) rise in serum thyrotrophin (TSH) was found after LH/FSH-RH in doses ranging from 25 to 400 μg. There was no significant rise in serum growth hormone (HGH). On the basis of the present study a standard 100 μg iv LH/FSH-RH test is suggested.

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