Sex hormone binding globulin in arterial, and in peripheral, hepatic, renal and spermatic venous blood of children and adults

1983 ◽  
Vol 103 (3) ◽  
pp. 428-432 ◽  
Author(s):  
A. Belgorosky ◽  
C. Scorticati ◽  
M. A. Rivarola
Keyword(s):  
Sertoli Cells ◽  
Venous Blood ◽  
Hepatic Clearance ◽  
Sex Hormone ◽  
Splanchnic Circulation ◽  
Sex Hormone Binding Globulin ◽  
Seminiferous Tubules ◽  
Hormone Binding ◽  
Peripheral Tissues ◽  
Arterial Blood

Abstract. Human sex hormone binding globulin (SHBG) was measured in arterial serum and in serum obtained from different venous territories. In 6 children, SHBG ranged from 44.4 ± 4.8 (mean ± sd) in arterial blood to 55.3 ± 5.3 in the hepatic vein (P < 0.01), while it did not change significantly in renal or peripheral tissue venous blood. In 6 male adults, no significant arteriovenous differences were found either in the peripheral tissues or in the splanchnic circulation. In the spermatic vein of 8 subjects, SHGB was significantly lower (17.1 ± 5.7) than in the arterial blood (22.8 ± 7.5), P < 0.025. The arterio-venous difference found in the splanchnic circulation of children supports the hepatic origin of SHBG, and also suggests extra-hepatic clearance of the binding globulin. Testicular uptake of SHBG might be necessary to regulate delivery of androgens to Sertoli cells in the seminiferous tubules.

Plasma sex hormone-binding globulin and androgen levels in the management of hirsute patients

1983 ◽  
Vol 104 (3) ◽  
pp. 365-371 ◽  
Author(s):  
Sean K. Cunningham ◽  
Therese Loughlin ◽  
Marie Culliton ◽  
T. Joseph McKenna
Keyword(s):  
Clinical Presentation ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Plasma Testosterone ◽  
Hormone Binding ◽  
Peripheral Tissues ◽  
Androgen Action ◽  
Dexamethasone Therapy ◽  
Increased Sensitivity ◽  
Clinical Changes

Abstract. Hirsutism in women is a manifestation of escessive androgen action. This my be due to excessive exposure, or to increased sensitivity, of peripheral tissues to androgens. The present study was undertaken to estimate the percentage of hirsute patients with hyperandrogenaemia and to examine the effect of correction of hyperandrogenaemia on the clinical presentation. Plasma testosterone, dihydrotestosterone, sex hormone-binding globulin (SHBG) and androstenedione were determined in 58 hirsute patients before and following 3 months therapy with dexamethasone, 0.5 mg nocte. Testosterone expressed as a function of SHBG (testosterone/SHBG) provides an index of the non-protein bound testosterone fraction. Plasma levels of androstenedione were significantly elevated in 28% of hirsute patients, testosterone in 31% and testosterone/SHBG was elevated in 52%. Five per cent of patients had an elevated androstenedione value together with a normal testosterone/SHBG value. A subgroup of 13 hirsute patients with oligomenorrhoea had significantly higher values for androstenedione and testosterone/SHBG than eumenorrhoeic hirsute patients, and plasma testosterone, androstenedione and testosterone/SHBG values were more frequently elevated. In hirsute patients dexamethasone therapy resulted in suppression of plasma testosterone and androstenedione values, a significant increase in plasma SHBG and a marked fall in testosterone/SHBG. Following treatment with dexamethasone hyperandrogenaemia was corrected in 64% of hirsute patients, a decrease in the rate of hair growth or a resumption of a normal menstrual pattern occurred in 70% and concordant hormonal and clinical changes occurred in 79% of patients. These observations indicate that the testosterone/SHBG ratio is a sensitive index of hyperandrogenaemia, the correction of which is associated with clinical improvement.

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

Sex hormone-binding globulin (SHBG) and androgen levels in women with androgenetic alopecia

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S144 ◽  
Author(s):  
G. SINNECKER ◽  
E. LUDWIG ◽  
A. KRENZ ◽  
R.P. WILLIG
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Androgenetic Alopecia ◽  
Hormone Binding ◽  
Androgen Levels

Characterization of sex hormone binding globulin ligands with potential to enhance sex steroid action

2018 ◽  
Author(s):  
Phillip Round ◽  
Samir Das ◽  
Kristiina Wahala ◽  
Petegem Filip Van ◽  
Geoffrey Hammond
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Hormone Binding
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