Thyroid hormone regulation of the catecholamine effects in human adipose tissue

1981 ◽  
Vol 96 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Peter Arner ◽  
Anders Wennlund ◽  
Jan Östman
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Cyclic Amp ◽  
Thyroid Hormones ◽  
Hormone Level ◽  
Normal Weight ◽  
Thyroid Hormone Level ◽  
Hormone Regulation ◽  
Vitro Effect

Abstract. The possibility of a relationship between the thyroid hormone level and the peripheral action of catecholamines was examined in 4 normal-weight and 19 obese euthyroid subjects as well as in 27 hyperthyroid subjects by comparing the serum thyroid hormone level and the in vitro effect of catecholamines on lipolysis and cyclic AMP accumulation in adipose tissue incubated with and without isopropyl noradrenaline (ISNA) or noradrenaline (NA). ISNA- and NA-induced rates of lipolysis and cyclic AMP production were significantly correlated with free thyroxine index (r = 0.63–0.74) and with the serum triiodothyronine level (r = 0.83–0.87). The thyroid hormone level was neither correlated with basal rate of lipolysis nor with basal cyclic AMP production (r < 0.2). These results suggest that the magnitude of catecholamine-induced cyclic AMP production by peripheral cells may be regulated by the level of circulating thyroid hormones. The effect of thyroid hormones on lipolysis appears to be specifically linked to the action of catecholamines.

Brown Adipose Tissue (BAT) detection by 18F-FDG PET and thyroid hormone level(s)—a systematic review

Endocrine ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 496-500 ◽  
Author(s):  
Prasanna Santhanam ◽  
Rexford S Ahima ◽  
Jennifer S Mammen ◽  
Luca Giovanella ◽  
Giorgio Treglia
Keyword(s):  
Systematic Review ◽  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Hormone Level ◽  
Thyroid Hormone Level ◽  
Brown Adipose ◽  
18F Fdg ◽  
Bat Detection

Influence of thyroid hormone level on insulin action in human adipose tissue

Diabetes ◽  
1984 ◽  
Vol 33 (4) ◽  
pp. 369-375 ◽  
Author(s):  
P. Arner ◽  
J. Bolinder ◽  
A. Wennlund ◽  
J. Ostman
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Insulin Action ◽  
Hormone Level ◽  
Human Adipose Tissue ◽  
Thyroid Hormone Level

Influence of Thyroid Hormone Level on Insulin Action in Human Adipose Tissue

Diabetes ◽  
1984 ◽  
Vol 33 (4) ◽  
pp. 369-375 ◽  
Author(s):  
P. Arner ◽  
J. Bolinder ◽  
A. Wennlund ◽  
J. Ostman
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Insulin Action ◽  
Hormone Level ◽  
Human Adipose Tissue ◽  
Thyroid Hormone Level

scholarly journals Clearing-factor lipase in adipose tissue. A possible role of adenosine 3′,5′-(cyclic)-monophosphate in the regulation of its activity

1968 ◽  
Vol 109 (5) ◽  
pp. 841-849 ◽  
Author(s):  
D. R. Wing ◽  
D S Robinson
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Cyclic Amp ◽  
Lipase Activity ◽  
Glucose Concentration ◽  
Free Fatty Acid Concentration ◽  
Epididymal Fat ◽  
Fat Bodies

1. The rise in clearing-factor lipase activity that occurs when epididymal fat bodies from starved rats are incubated in appropriate media in vitro is inhibited in the presence of 6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP (1mm). 2. Inhibition occurs at a concentration of glucose in the incubation medium of 1·3mg./ml. or less, but not at a glucose concentration of 2·4mg./ml., unless caffeine (1mm), an inhibitor of 3′,5′-(cyclic)-nucleotide phosphodiesterase, is also present. Caffeine (5mm) alone inhibits the rise in clearing-factor lipase activity at a glucose concentration of 2·4mg./ml. of medium. 3. The concentration of free fatty acids in the epididymal fat bodies normally falls during incubations in vitro as the rise in clearing-factor lipase activity occurs. In the presence of 1mm-6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP, however, either the tissue free fatty acid concentration is increased or it does not fall to the same extent. The concentration of glucose in the incubation medium is important in determining the direction and extent of the changes in tissue free fatty acid concentration that occur in the presence of 6-N-2′-O-dibutyryl-3′,5′-(cyclic)-AMP. 4. Free fatty acid concentrations in epididymal fat bodies in vivo rise as the clearing-factor lipase activity of the tissue falls during starvation. 5. The possibility that the concentration of 3′,5′-(cyclic)-AMP in adipose tissue may regulate clearing-factor lipase activity, and that the regulation may occur through effects of the nucleotide on tissue free fatty acid concentrations, is discussed.

Interactive in vitro effect of prolactin, growth hormone and season on leptin secretion by ovine adipose tissue

2011 ◽  
Vol 100 (2-3) ◽  
pp. 177-183 ◽  
Author(s):  
M. Szczesna ◽  
D.A. Zieba ◽  
B. Klocek-Gorka ◽  
D.H. Keisler
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Vitro Effect

Effects of hormones on cyclic AMP release from rat adipose tissue in vitro

FEBS Letters ◽  
1974 ◽  
Vol 49 (1) ◽  
pp. 65-69 ◽  
Author(s):  
P. Zumstein ◽  
J. Zapf ◽  
E.R. Froesch
Keyword(s):  
Adipose Tissue ◽  
Cyclic Amp ◽  
Adipose Tissue In Vitro ◽  
Rat Adipose Tissue

Effects of epinephrine on regional free fatty acid and energy metabolism in men and women

1996 ◽  
Vol 270 (2) ◽  
pp. E259-E264 ◽  
Author(s):  
M. D. Jensen ◽  
P. E. Cryer ◽  
C. M. Johnson ◽  
M. J. Murray
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fat Distribution ◽  
Normal Weight ◽  
Upper Body ◽  
Lower Body ◽  
Men And Women

Upper-body and lower-body adipocytes respond differently to physiological catecholamines in vitro. It is not known whether this is true in vivo or whether gender differences exist in the regional adipose tissue responses to epinephrine. These studies were therefore conducted to examine free fatty acid (FFA) release ([3H]palmitate) from lower-body (leg), splanchnic, and upper-body adipose tissue in normal-weight adult men (n = 8) and women (n = 7). In response to intravenous epinephrine (10 ng.kg-1.min-1), palmitate release increased (P < 0.01) in both men (168 +/- 10 to 221 +/- 15 mumol/min) and women (177 +/- 12 to 234 +/- 18 mumol/min). Basal leg palmitate release was similar in women and men (16.8 +/- 2.9 and 12.4 +/- 1.3 mumol/min, P = not significant) but doubled (P < 0.01) in response to epinephrine in men and was virtually unchanged in women. Splanchnic palmitate release increased (P < 0.05) in men (n = 6) but not in women (n = 6), whereas nonsplanchnic upper-body palmitate release increased more in women than in men. Upper-body (splanchnic and nonsplanchnic) palmitate release increased (P < 0.05) in both men and women in response to epinephrine. In summary, lower-body adipose tissue FFA release increased in response to epinephrine in men but not women, whereas upper-body palmitate release increased in both groups. These findings are consistent with some in vitro findings and suggest that catecholamine action may play a role in determining gender-based differences in body fat distribution.

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