Renal handling of 3,3',5'-triiodothyronine (reverse T3) compared to thyroxine and 3,5,3'-triiodothyronine in different thyroid function states in man

1980 ◽  
Vol 94 (3) ◽  
pp. 337-340 ◽  
Author(s):  
Preben Rogowski ◽  
Jens Faber ◽  
Kaj Siersbæk-Nielsen
Keyword(s):  
Glomerular Filtration ◽  
Renal Clearance ◽  
Serum Concentrations ◽  
Transport Mechanisms ◽  
Reverse T3 ◽  
Renal Handling ◽  
Phenolic Ring ◽  
Tubular Transport ◽  
Hormone Excretion ◽  
Hyperthyroid Patients

Abstract. The aim of the present work was to investigate the renal clearance of 3,3',5'-triiodothyronine (reverse T3, rT3) compared to thyroxine (T4) and 3,5,3'-triiodothyronine (T3) clearance. The urinary excretion of T4. T3 and rT3 was estimated by radioimmunoassay, serum unbound hormones (AFT4, AFT3, AFrT3) were measured using ultrafiltration technique. In 27 euthyroid controls the 24 h urinary T4 excretion was in median 1.7 nmol. T3 excretion 0.8 nmol and rT3 excretion 0.08 nmol. Serum AFT4 was in median 59 pmol/l, AFT3 7.9 pmol/l and AFrT3 2.2 pmol/l. Creatinine clearance was in median 93 ml/min. Median renal clearance of T4, T3 and rT3 were 26, 70 and 25 ml/min, and apparent tubular re-absorption was in average 77, 27 and 77%, respectively. In 18 hyperthyroid patients urinary hormone excretion was highly increased and was found parallel to the increase in serum concentrations of free hormones. Clearance and per cent tubular re-absorption of T4 and rT3 were equal to and not different from control values, but T3 clearance seemed to be increased to values higher than glomerular filtration rate (GFR). In 8 patients with hypothyroidism low urinary hormone excretion was found. Clearance of T4 and rT3 did not differ from control values, but T3 clearance was reduced. Our data show that T4, T3 and rT3 are excreted by glomerular filtration of free hormones and suggest that tubular transport mechanisms are involved. The hypothesis is put forward that the renal handling of the thyronines is influenced by the number of the outer phenolic ring iodine atoms.

Renal handling of thyroxine, 3,5,3'- and 3,3',5'-triiodothyronine, 3,3'- and 3',5'-diiodothyronine in man

1987 ◽  
Vol 115 (1) ◽  
pp. 144-148 ◽  
Author(s):  
Jens Faber ◽  
Kaj Siersbæk-Nielsen ◽  
Carsten Kirkegaard
Keyword(s):  
Urinary Excretion ◽  
Creatinine Clearance ◽  
Iodine Atom ◽  
Healthy Subjects ◽  
Tubular Reabsorption ◽  
Transport Mechanisms ◽  
Renal Handling ◽  
Phenolic Ring ◽  
Tubular Transport ◽  
Renal Clearances

Abstract. The 24-h urinary excretion and renal clearance of thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,3'-diiodothyronine (3,3'-T2), and 3',5'-diiodothyronine (3',5'-T2) were measured in 17 healthy subjects. The median urinary excretion was (pmol/24h) T4: 1242, T3: 828, rT3: 12.9, 3,3'-T2: 331, and 3',5'-T2: 5.8. The corresponding renal clearances were in median (ml/min) T4: 31, T3: 133, rT3: 15, 3,3'-T2: 683, and 3',5'-T2: 4.5. The clearances differed mutually (P < 0.01) as well as from the creatinine clearance (P < 0.01) which was in median 87 ml/min. Thus, all iodothyronines studied were subject to tubular transport mechanisms besides glomerular filtration. The 3 iodothyronines with 2 iodine atoms in the phenolic ring of the thyronine molecule, T4, rT3 and 3',5'-T2, were mainly tubularly reabsorbed, whereas those with only one iodine atom in the phenolic ring, T3 and 3,3'-T2, were mainly tubularly secreted. It might be hypothesized that the number of iodine atoms in the phenolic ring determines the direction of the tubular transport (presence of 2 iodine atoms is associated with tubular reabsorption, and of one iodine atom with secretion), whereas the rate of tubular transport decreases with decreasing number of iodine atoms in the tyrosylic ring.

Thyroxine in unextracted urine

1987 ◽  
Vol 114 (4) ◽  
pp. 503-508 ◽  
Author(s):  
I. Orden ◽  
J. Pie ◽  
M. G. Juste ◽  
J. A. Marsella ◽  
C. Blasco
Keyword(s):  
Urinary Excretion ◽  
Renal Clearance ◽  
Filtration Rate ◽  
Experimental Studies ◽  
Tubular Reabsorption ◽  
Enzyme Hydrolysis ◽  
Renal Handling ◽  
The Mean ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

Abstract. The aim of this work was to estimate the daily urinary excretion of free and conjugated thyroxine using a direct radioimmunoassay and enzyme hydrolysis. The renal clearance of free T4 was also determined. The mean urinary values of free and total T4 (mean ± 1 sd) in 112 euthyroid controls were 1353 ± 496 and 1855 ± 651 pmol/24 h, respectively. Urinary excretion of free hormone in 13 hyperthyroid patients was 5552 ± 4320 pmol/24 h and total T4 was 8122 ± 7219 pmol/24 h. Urinary free T4 excretion was 223 ± 223 pmol/24 h in hypothyroid patients and total T4 was 542 ± 490 pmol/24 h. These results indicate that daily urinary T4 excretion is a good indicator of thyroid function. The mean renal clearance of free T4 was 52 ± 19 ml/min (mean ± 1 sd) in euthyroid patients, 53.7 ± 12.3 ml/min in hyperthyroid patients, and 67.6 ± 13.1 ml/min in hypothyroid patients. We estimated the endogenous creatinine renal clearance as a control of the renal filtration rate. The data suggest that there is T4 filtration of unbound T4 and partial tubular reabsorption. Further experimental studies will be necessary to clarify the renal handling of thyroxine as well as the fate of reabsorbed T4.

Excretion of progastrin products in human urine

1999 ◽  
Vol 276 (4) ◽  
pp. G985-G992 ◽  
Author(s):  
C. Palnaes Hansen ◽  
J. P. Goetze ◽  
F. Stadil ◽  
J. F. Rehfeld
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Plasma Concentrations ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Renal Handling ◽  
Renal Metabolism ◽  
Tubular Transport ◽  
Excretion Rates

The renal handling of carboxyamidated gastrins, NH2-terminal progastrin fragments, and glycine-extended gastrins was examined in healthy volunteers. The respective urinary clearances after a meal amounted to 0.09 ± 0.02%, 0.17 ± 0.04% ( P< 0.05), and 0.04 ± 0.01% ( P< 0.01) of the glomerular filtration rate. During intravenous infusion of carboxyamidated gastrin-17, progastrin fragment-(1—35), and glycine-extended gastrin-17, the respective urinary clearances amounted to 0.08 ± 0.02, 0.46 ± 0.08, and 0.02 ± 0.01%, respectively, of the glomerular filtration rate. The metabolic clearance rate of the three peptides was 24.4 ± 1.3, 6.0 ± 0.4, and 8.6 ± 0.7 ml ⋅ kg−1⋅ min−1. A maximum rate for tubular transport or degradation of the peptides could not be determined, nor was a renal plasma threshold recorded. Plasma concentrations and urinary excretion rates correlated for gastrin-17 and progastrin fragment-(1—35) ( r = 0.94 and 0.97, P < 0.001), whereas the excretion of glycine-extended gastrin diminished with increasing plasma concentrations. We conclude that renal excretion of progastrin products is negligible compared with renal metabolism and that renal handling of the peptides depends on their molecular structure. Hence, the kidneys exhibited a higher excretion of NH2-terminal progastrin fragments than of carboxyamidated and especially glycine-extended gastrins.

URINARY EXCRETION OF THYROXINE AND TRIIODOTHYRONINE IN DIFFERENT THYROID FUNCTION STATES IN MAN

1978 ◽  
Vol 87 (3) ◽  
pp. 525-534 ◽  
Author(s):  
Preben Rogowski ◽  
Kaj Siersbæk-Nielsen ◽  
Jens Mølholm Hansen
Keyword(s):  
Renal Function ◽  
Thyroid Hormone ◽  
Creatinine Clearance ◽  
Practical Importance ◽  
Serum Concentrations ◽  
Mean Values ◽  
Age Dependent ◽  
Hormone Excretion ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

ABSTRACT Urinary thyroxine (T4) and triiodothyronine (T3) have been measured by radioimmunoassay using trapping and separation on small Sephadex® columns. Serum concentrations of total and free T4 and T3 and endogenous creatinine clearance was also estimated. In 67 euthyroid controls the 24 h urinary T4 excretion varied in parallel with age dependent changes in renal function from mean 1788 to 1051 ng. Urinary T3 also decreased with age from mean 635 to 280 ng/24 h. Mean urinary clearance of T4 varied from 40.4 to 22.1 ml/min and T3 clearance from 160 to 107 ml/min parallel with creatinine clearance. The corresponding mean creatinine clearance values varied from 95 to 57 ml/min. In 24 hyperthyroid patients urinary T4 and T3 were highly increased, dependent on elevated free hormones in the serum to mean 3505 and 3865 ng/24 h. The corresponding T4 and T3 clearance mean values were 16.7 and 90.0 ml/min. In 7 untreated hypothyroid patients very low urinary T4 and T3 values were found on average 139 and 60 ng/24 h. Estimation of urinary thyroid hormones can be used for diagnostic purposes but is of limited practical importance. The physiology of thyroid hormone excretion in urine is complex. Both hormones are excreted by glomerular filtration of free hormones including tubular excretion and reabsorption.

Kinetics of Various 99mTc-Sn-Pyrophosphate Compounds in the Rat

1977 ◽  
Vol 16 (03) ◽  
pp. 100-103 ◽  
Author(s):  
C. Schümichen ◽  
J. Waiden ◽  
G. Hoffmann
Keyword(s):  
Glomerular Filtration ◽  
Renal Clearance ◽  
Plasma Protein ◽  
Kinetic Data ◽  
Adult Rats ◽  
Compound A ◽  
Extravascular Space ◽  
Tubular Cells ◽  
Glomerular Filtrate ◽  
Kinetics Of

SummaryThe kinetic data of two different 99mTc-Sn-pyrophosphate compounds (compound A and B) were evaluated in non-adult rats. Only compound A concentrated in bone. Both compounds dispersed rapidly in the intravascular as well as the extravascular space. The plasma protein bond of both compounds increased with time after injection and impaired both the renal clearance of both compounds and the bone clearance of compound A. The renal clearance of both compounds was somewhat above that of 5 1Cr-EDTA. It is concluded that compound A and B is mainly excreted by glomerular filtration. About one fourth of the glomerular filtrate of compound B is reabsorbed and accumulated by the tubular cells.

Influence of the Glomerular Filtration Rate on Renal Clearance of Ceftazidime in Cystic Fibrosis

1988 ◽  
Vol 15 (1) ◽  
pp. 57-65 ◽  
Author(s):  
A. Hedman ◽  
Y. Adan-Abdi ◽  
G. Alvan ◽  
B. Strandvik ◽  
A. Arvidsson
Keyword(s):  
Cystic Fibrosis ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Renal Clearance ◽  
Filtration Rate

scholarly journals MYOHEMOGLOBINURIA

1941 ◽  
Vol 74 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Charles L. Yuile ◽  
William F. Clark
Keyword(s):  
Molecular Weight ◽  
Plasma Concentration ◽  
Creatinine Clearance ◽  
Glomerular Filtration ◽  
Renal Clearance ◽  
Renal Excretion ◽  
Clearance Ratio ◽  
A Value ◽  
Blood Hemoglobin

When myohemoglobin is injected intravenously into dogs, in amounts ranging from 0.75 to 1.50 gm., it is rapidly eliminated from the plasma and approximately 65 per cent is excreted by the kidneys in from 1½ to 2½ hours. Myohemoglobin does not appear in the urine below a threshold plasma concentration which is slightly under 20 mg. per 100 cc. but above this level the rate of renal excretion is directly proportional to the plasma concentration. The maximum myohemoglobin/creatinine clearance ratio averages 0.58 contrasted with a value of 0.023 for blood hemoglobin. This indicates that the rate of renal clearance of myohemoglobin is twenty-five times more rapid than that of blood hemoglobin. Evidence is presented that the excretory mechanism is essentially similar for the two substances but that differences in molecular weight account for different rates of glomerular filtration.

Cystatin C provides a better estimate of the effect of glomerular filtration rate on serum human epididymis protein 4 concentrations

2016 ◽  
Vol 54 (10) ◽  
Author(s):  
Simona Ferraro ◽  
Sara Pasqualetti ◽  
Assunta Carnevale ◽  
Mauro Panteghini
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Concentrations ◽  
Glomerular Function ◽  
Human Epididymis Protein 4 ◽  
Disease Epidemiology ◽  
Human Epididymis

AbstractBackground:We evaluated the effect of kidney glomerular function on serum concentrations of human epididymis protein 4 (HE4) using creatinine (Cr), cystatin C (CysC) and related chronic kidney disease epidemiology collaboration (CKD-EPI) equations.Methods:We enrolled 101 women aged ≤56 years with a glomerular filtration rate (GFR) (estimated by CKD-EPI eGFRResults:A statistically significant increase in HE4 median concentrations was detected in subjects with an eGFRConclusions:Our study shows that a better estimate of the effect of GFR on serum HE4 is obtained by measuring CysC in serum or using CKD-EPI eGFR

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