The effect of cyproterone acetate on serum lipids in normal men

1980 ◽  
Vol 94 (2) ◽  
pp. 280-283 ◽  
Author(s):  
Finn Damgaard-Pedersen ◽  
Marie Føgh
Keyword(s):  
Cyproterone Acetate ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Serum Testosterone ◽  
Tolerance Test ◽  
Low Doses ◽  
Testosterone Concentration ◽  
Fat Tolerance Test ◽  
Normal Men ◽  
Atherosclerotic Risk Factors

Abstract. In a male anti-fertility study 7 volunteers received the anti-androgen cyproterone acetate (5 or 10 mg daily) orally in a paired study. A significant reduction in serum-cholesterol and LDL-cholesterol, and a significant increase in the intravenous-fat-tolerance-test (IVFTT) was observed. Thus low doses of cyproterone acetate reduced the serum testosterone concentration and some of the atherosclerotic risk factors.

RISE IN DEHYDROEPIANDROSTERONE AND OESTROGENS DURING CLOMIPHENE ADMINISTRATION IN NORMAL MEN

1976 ◽  
Vol 83 (1) ◽  
pp. 166-172 ◽  
Author(s):  
J. P. Kampmann ◽  
F. Schønau Jørgensen ◽  
E. P. Bennett ◽  
Svend G. Johnsen
Keyword(s):  
Urinary Excretion ◽  
Clomiphene Citrate ◽  
Serum Testosterone ◽  
Daily Administration ◽  
Independent Effect ◽  
Serum Concentrations ◽  
Testosterone Concentration ◽  
Adrenal Steroidogenesis ◽  
Free Cortisol ◽  
Normal Men

ABSTRACT Serum concentrations of LH, FSH and testosterone, and urinary excretion of individual 17-ketosteroids, oestrogenic substances and free cortisol was investigated in 12 normal men after a daily administration of 50 mg clomiphene citrate for 14 days. A significant increase in the serum concentrations of LH, FSH and testosterone was seen after 8 days with a further increase when measured a week later. The percentual increase in urinary excretion of oestrogens and dehydroepiandrosterone was of the same order as the increase in serum testosterone concentration whereas the increase in androsterone and a aetiocholanolone was significantly lower. The excretion of free cortisol was unaltered. The study indicates that measurements of oestrogens in the urine might be used as a parameter of the stimulatory effect of clomiphene on the hypothalamic - pituitary - gonadal axis in man. In addition, the results support the hypothesis of an independent effect of clomiphene on adrenal steroidogenesis, not related to the production of glucocorticoids.

An investigation of LH pulsatility in burned men by bioassay and radioimmunoassay

1992 ◽  
Vol 126 (5) ◽  
pp. 404-409 ◽  
Author(s):  
CG Semple ◽  
R Mitchell ◽  
S Hollis ◽  
WR Robertson
Keyword(s):  
Biological Activity ◽  
Serum Testosterone ◽  
Normal Subjects ◽  
Published Data ◽  
Blood Samples ◽  
Testosterone Concentration ◽  
Lh Pulsatility ◽  
Pulse Peak ◽  
The Mean ◽  
Normal Men

LH pulsatility studies were performed in six burned patients by removing blood samples at 10 min intervals over a 6 h period. All samples were assayed for LH by bioassay (B-LH), LH by radioimmunoassay (I-LH) and testosterone. Mean serum testosterone concentrations of the burned patients were low (6.7±1.6 nmol/l). I-LH levels were lower than B-LH in all samples. Frequency of bioactive or immunoreactive pulses as well as mean B-LH and I-LH concentrations were similar to previously published data from normal men examined in the same laboratory. The mean biological activity of LH (expressed as the ratio of B-LH to I-LH, the B:I ratio) was lower in burned subjects (1.9±0.1) than previously reported in normal men. The B:I ratios of burned men were lower (p <0.01) at pulse peaks than at nadirs (1.8±0.1 vs 2.0±0.1) and an increase in serum testosterone concentration did not follow an LH peak. Serum testosterone concentrations did not cross-correlate with B-LH or I-LH. This contrasts with the findings in normal subjects where the B:I ratios have been found to be higher at pulse peaks than at nadirs and an increase in serum testosterone concentration follows a pulse peak and serum testosterone cross-correlates with B-LH and I-LH. LH secreted in a pulse peak in normal men may contain a particularly biologically potent form of the molecule but this may not be the case in burned men.

Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy

1997 ◽  
pp. 495-502 ◽  
Author(s):  
AM Heikkinen ◽  
MT Tuppurainen ◽  
L Niskanen ◽  
M Komulainen ◽  
I Penttila ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Cyproterone Acetate ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hormone Replacement ◽  
Density Lipoprotein ◽  
Estradiol Valerate ◽  
Serum Concentrations ◽  
Vitamin D3 Supplementation

OBJECTIVE: The positive short-term effects of postmenopausal hormone replacement therapy (HRT) on serum lipids are well known, but it has been suggested that they vanish with time. Cholecalciferol (vitamin D3) is widely used to prevent postmenopausal osteoporosis but the influence of vitamin D3 on serum lipids is poorly known. The long-term effects of HRT and vitamin D3 on the concentrations of serum lipids were studied in a population-based prospective 3-year study. DESIGN AND METHODS: 464 women were randomized into four treatment groups: (i) HRT (sequential combination of 2 mg estradiol valerate and 1 mg cyproterone acetate), (ii) Vit D3 (vitamin D3 300 IU/day), (iii) HRT+Vit D3 (both as above), (iv) placebo (calcium lactate 500 mg/day). RESULTS: 320 women completed the study. After three years of treatment, serum concentrations of low density lipoprotein (LDL) cholesterol decreased in the HRT group (10.1%, P<0.001) and the HRT+Vit D3 group (5.9%, P=0.005), increased in the Vit D3 group (4.1%, P=0.035) but remained unchanged in the placebo group. The concentrations of total cholesterol decreased by 5.8% in the HRT group (P<0.001) and by 3.3% in the HRT+Vit D3 group (P=0.023), but did not change in the other two groups. Serum concentrations of high density lipoprotein (HDL) cholesterol decreased in the Vit D3 group (5.2%, P=0.001), HRT+Vit D3 group (3.7%, P=0.046), and the placebo group (4.5%, P=0.006) but did not change significantly in the HRT group. The HDL/LDL ratio increased in the HRT group (10.5%, P=0.006) and decreased in the Vit D3 group (10.5%, P<0.001) whereas no changes occurred in the other two groups. In addition, serum triglycerides increased similarly in all groups (14.0-18.8%, P<0.05-0.001). CONCLUSIONS: Our results confirm the positive long-term effect of HRT with sequential estradiol valerate and cyproterone acetate on serum lipid concentrations. In addition, the results suggest that vitamin D3 supplementation may have unfavorable effects on lipids in postmenopausal women. Pure vitamin D3 treatment was associated with increased serum LDL cholesterol. Furthermore, the beneficial effects of HRT on serum LDL cholesterol content were reduced when estradiol valerate was combined with vitamin D3. However, the relevance of these associations to cardiovascular morbidity remains to be established.

scholarly journals Effects of guar gum on serum lipids and plasma free amino acids of healthy females at fat tolerance test.

1985 ◽  
Vol 38 (1) ◽  
pp. 25-31
Author(s):  
Kimiko OHTANI ◽  
Misako SHIBATA ◽  
Masako YOSHIOKA ◽  
Katsuhisa KITADA ◽  
Yoshiki SATO ◽  
...  
Keyword(s):  
Amino Acids ◽  
Free Amino Acids ◽  
Free Amino ◽  
Serum Lipids ◽  
Guar Gum ◽  
Tolerance Test ◽  
Fat Tolerance Test ◽  
Plasma Free Amino Acids ◽  
Healthy Females

Intravenous Fat-Tolerance Test in Ischaemic Heart Disease and Peripheral Vascular Disease

1976 ◽  
Vol 51 (4) ◽  
pp. 415-420
Author(s):  
B. Lewis ◽  
A. C. Onitiri ◽  
I. D. P. Wootton ◽  
A. Chait ◽  
G. Sigurdsson ◽  
...  
Keyword(s):  
Heart Disease ◽  
Vascular Disease ◽  
Ischaemic Heart Disease ◽  
Peripheral Vascular Disease ◽  
Turnover Rate ◽  
Serum Triglyceride ◽  
Tolerance Test ◽  
Peripheral Vascular ◽  
Fat Tolerance Test ◽  
Normal Men

1. The intravenous fat-tolerance test and serum lipid and lipoprotein measurements were carried out in ninety-three normal subjects, fifty-one patients with ischaemic heart disease and thirty patients with peripheral vascular disease. 2. The fractional turnover rate of exogenous triglyceride was significantly slower in patients with ischaemic heart disease and in patients with peripheral vascular disease than in normal men. The rate was also slower in normal men than normal women. 3. Serum triglyceride and cholesterol concentrations were higher in both vascular disease groups than in control subjects. 4. The proportion of both groups of patients who had a subnormal fractional turnover rate of exogenous triglyceride was 35%, and 32% of patients had hypertriglyceridaemia in the fasting state; 27% of patients were hypercholesterolaemic. 5. Although the intravenous fat-tolerance test did not provide significantly better discrimination between cardiovascular patients and control subjects than did measurement of serum triglyceride, the results suggest that hypertriglyceridaemia in such patients may be separable into a group in which impaired triglyceride clearance may be partly responsible, and a group in which overproduction of serum triglyceride may be the major mechanism of the hyperlipidaemia.

The Effects of L-Carnitine Supplementation on Serum Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 25 (30) ◽  
pp. 3266-3281 ◽  
Author(s):  
Hadis Fathizadeh ◽  
Alireza Milajerdi ◽  
Željko Reiner ◽  
Fariba Kolahdooz ◽  
Maryam Chamani ◽  
...  
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Health Conditions ◽  
Carnitine Supplementation ◽  
Randomized Controlled ◽  
Cholesterol Levels ◽  
Vldl Cholesterol ◽  
Subgroup Analyses

Background: The findings of trials investigating the effects of L-carnitine administration on serum lipids are inconsistent. This meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effects of L-carnitine intake on serum lipids in patients and healthy individuals. Methods: Two authors independently searched electronic databases including MEDLINE, EMBASE, Cochrane Library, Web of Science, PubMed and Google Scholar from 1990 until August 1, 2019, in order to find relevant RCTs. The quality of selected RCTs was evaluated using the Cochrane Collaboration risk of bias tool. Cochrane’s Q test and I-square (I2) statistic were used to determine the heterogeneity across included trials. Weight mean difference (SMD) and 95% CI between the two intervention groups were used to determine pooled effect sizes. Subgroup analyses were performed to evaluate the source of heterogeneity based on suspected variables such as, participant’s health conditions, age, dosage of L-carnitine, duration of study, sample size, and study location between primary RCTs. Results: Out of 3460 potential papers selected based on keywords search, 67 studies met the inclusion criteria and were eligible for the meta-analysis. The pooled results indicated that L-carnitine administration led to a significant decrease in triglycerides (WMD: -10.35; 95% CI: -16.43, -4.27), total cholesterol (WMD: -9.47; 95% CI: - 13.23, -5.70) and LDL-cholesterol (LDL-C) concentrations (WMD: -6.25; 95% CI: -9.30, -3.21), and a significant increase in HDL-cholesterol (HDL-C) levels (WMD: 1.39; 95% CI: 0.21, 2.57). L-carnitine supplementation did not influence VLDL-cholesterol concentrations. When we stratified studies for the predefined factors such as dosage, and age, no significant effects of the intervention on triglycerides, LDL-C, and HDL-C levels were found. Conclusion: This meta-analysis demonstrated that L-carnitine administration significantly reduced triglycerides, total cholesterol and LDL-cholesterol levels, and significantly increased HDL-cholesterol levels in the pooled analyses, but did not affect VLDL-cholesterol levels; however, these findings were not confirmed in our subgroup analyses by participant’s health conditions, age, dosage of L-carnitine, duration of study, sample size, and study location.

Social Dominance and Serum Testosterone Concentration in Dyads of Male Macaca fascicularis

1986 ◽  
Vol 15 (6) ◽  
pp. 419-432 ◽  
Author(s):  
Margaret R. Clarke ◽  
Jay R. Kaplan ◽  
Patricia T. Bumsted ◽  
Donald R. Koritnik
Keyword(s):  
Social Dominance ◽  
Macaca Fascicularis ◽  
Serum Testosterone ◽  
Testosterone Concentration

scholarly journals Fat tolerance test in pregnancy: Intralipid loading test.

1981 ◽  
Vol 134 (2) ◽  
pp. 195-201
Author(s):  
TAMOTSU YOSHIOKA ◽  
SHUJI KOIKE ◽  
HIROYUKI OKAMOTO
Keyword(s):  
Tolerance Test ◽  
Loading Test ◽  
Fat Tolerance Test ◽  
In Pregnancy

Saliva and serum testosterone following oral testosterone undecanoate administration in normal and hypogonadal men

1983 ◽  
Vol 102 (3) ◽  
pp. 456-462 ◽  
Author(s):  
Th. Schürmeyer ◽  
E. J. Wickings ◽  
C. W. Freischem ◽  
E. Nieschlag
Keyword(s):  
Interindividual Variability ◽  
Serum Testosterone ◽  
Serum Samples ◽  
Additional Increase ◽  
Testosterone Undecanoate ◽  
Absorption Pattern ◽  
High Interindividual Variability ◽  
Normal Men ◽  
Hydrolysis Of ◽  
Testosterone Ester

Abstract. Since saliva testosterone reflects the testosterone fraction available to target tissues the therapeutic effectiveness of orally administered testosterone undecanoate was assessed by measuring testosterone in serum and saliva. Matched saliva and serum samples were obtained from 12 normal men and 8 hypogonadal men before and at hourly intervals after the oral administration of 120 mg testosterone undecanoate. The test was repeated in 3 men after they had taken 40 mg testosterone undecanoate twice daily for 4 to 5 weeks. Following testosterone undecanoate administration serum and saliva testosterone always showed parallel increases. However, the absorption curves showed a high interindividual variability in the time when maximum concentrations were reached, as well as in the maximum levels themselves. The increases in serum and saliva testosterone were similar in normal and hypogonadal men. In normal men basal levels were reached 4 h after the maximum had occurred, while in hypogonadal men testosterone levels were not different from basal levels 2 h after the maximum. The study shows that testosterone undecanoate is well absorbed from the gut and releases significantly elevated amounts of testosterone which is available to target tissues. As the absorption pattern was always parallel in both fluids, hydrolysis of the circulating testosterone ester by the tissue ifself seems to effect no additional increase of testosterone in the tissue.

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