EFFECT OF ENDOGENOUS THYROID STIMULATING HORMONE LEVELS ON THE SECRETION OF THYROID HORMONES IN MAN

1979 ◽  
Vol 92 (1) ◽  
pp. 73-84 ◽  
Author(s):  
A. Carpi ◽  
R. Bianchi ◽  
G. C. Zucchelli ◽  
L. Del Corso ◽  
C. Levanti ◽  
...  
Keyword(s):  
Thyroid Tissue ◽  
Serum Levels ◽  
Progressive Increase ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
Surgical Removal ◽  
Thyroid Secretion ◽  
Serum Tsh ◽  
Stimulation Of ◽  
Stimulating Hormone

ABSTRACT The effect of endogenous thyroid stimulating hormone (TSH) on the thyroid secretion of triiodothyronine (T3) and thyroxine (T4) was evaluated by serial determinations of serum T3, T4 and TSH concentrations in the following groups of patients: a) three patients submitted to surgical removal of a solitary, autonomous thyroid nodule which had completely inhibited the extranodular tissue; b) five subjects, with the same disease, in whom functional recovery of the extranodular tissue was induced by increased circulating TSH levels, produced by treatment with methimazole; c) one patient submitted to hemithyroidectomy for multinodular goitre; d) two hyperthyroid patients who had been treated with methimazole. In all these patients serum T3 and T4 levels progressively decreased, with a consequent progressive increase in serum TSH concentrations, leading to stimulation of the thyroid gland. During this TSH-induced stimulation of thyroid tissue, a significant positive correlation was found between the serum TSH concentrations and the corresponding ratio betwen the serum levels of T3 and T4 (T3/T4), both within each patient group (P < 0.001) and among all patients (P < 0.001). The same correlation also governs the relationship between the TSH and the T3/T4 values of 34 euthyroid control subjects and one patient with incipient hypothyroidism. These data strongly suggest that endogenous TSH can induce a preferential secretion of T3 over T4 by the human thyroid.

scholarly journals Serum fetuin-A levels following recombinant human thyroid-stimulating hormone stimulation

2013 ◽  
Vol 36 (5) ◽  
pp. 264 ◽  
Author(s):  
AnneMarie Gagnon ◽  
Hussein Abujrad ◽  
Clara Irobi ◽  
Heather A Lochnan ◽  
Alexander Sorisky
Keyword(s):  
Thyroid Cancer ◽  
Cancer Recurrence ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
Fetuin A ◽  
Thyroxine Therapy ◽  
Inflammatory Conditions ◽  
Thyroid Cancer Recurrence ◽  
Stimulating Hormone

Purpose: Fetuin-A is a hepatokine that is linked to lipid metabolism, obesity, insulin resistance, type 2 diabetes and cardiovascular disease. Elevated thyroid-stimulating hormone (TSH) levels are associated with metabolic and cardiovascular disturbances. Our aim was to determine if TSH can regulate fetuin-A levels. Methods: Fetuin-A serum levels were examined in 26 subjects (19 women; previous thyroidectomy and radioactive iodine ablation) undergoing recombinant human TSH (rhTSH) stimulation to screen for thyroid cancer recurrence. Their age was 49±10 years, and body mass index (BMI) was 28±6 (both expressed as mean±SD). The patients received two doses of rhTSH (0.9 mg), administered 24 hours apart on days 1 and 2, without discontinuation of ongoing L-thyroxine therapy. Morning blood samples were obtained on days 1 (prior to the first dose of rhTSH), 3 and 5. Results: The baseline value of fetuin-A (mean±SD) for all participants was 527±186 mg/L. Values of fetuin-A did not change in response to rhTSH administration. The lack of response was not dependent on gender, age, baseline free thyroxine level or BMI. Conclusion: Fetuin-A has been implicated in metabolic and inflammatory conditions, but there have been no reports on whether fetuin-A is influenced by TSH. Within the context of rhTSH administration for surveillance of thyroid cancer recurrence, there was no effect on serum levels of fetuin-A.

Estrogen and thyroid-stimulating hormone (TSH) receptors in neoplastic and nonneoplastic human thyroid tissue

1985 ◽  
Vol 38 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Orlo H. Clark ◽  
Patricia L. Gerend ◽  
Mary Davis ◽  
Peter E. Goretzki ◽  
Philip G. Hoffman
Keyword(s):  
Thyroid Tissue ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
Human Thyroid Tissue ◽  
Stimulating Hormone

PITUITARY-THYROID INTERRELATIONSHIP IN RATS EXPOSED TO DIFFERENT ENVIRONMENTAL TEMPERATURES

1976 ◽  
Vol 83 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Eli Tal ◽  
Reuben Chayoth ◽  
Uriel Zor ◽  
Gideon Goldhaber ◽  
Avi Zerachie
Keyword(s):  
Steady State ◽  
Cyclic Amp ◽  
Thyroid Hormones ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Secretion Rate ◽  
Environmental Temperatures ◽  
Serum Tsh ◽  
Tsh Levels ◽  
Stimulating Hormone

ABSTRACT The present work intended to show interrelationships between triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and cyclic adenosine 3′5′-monophosphate (cyclic AMP) in both the pituitary and the thyroid. Experiments were carried out on animals exposed to 0 and 37°C for 4 days and to 34°C for 21 days. Control animals were maintained at 22°C. T4 serum levels of 2.6, 4.0, 1.1 and 0.42 μg/100 ml serum, and T3 levels of 95, 135, 65 and 36 ng/100 ml serum were recorded at 22, 0, 34 and 37°C, respectively. The observed serum TSH levels were 265, 192, 237 and 182 μg/100 ml serum in rats exposed to 22, 0, 34 and 37°C, respectively. Pituitary TSH content was similar at 22, 0 and 34°C whereas the content in the 37°C exposed rats was twice that of controls. Thyroid cyclic AMP levels were not significantly different among the various experimental groups. The content of cyclic AMP in the pituitary was higher at 34°C by 125 % and 37°C by 240 %, and lower at 0°C by 56 % with regard to the control. These results suggest that the 0 and 34°C exposed rats reach a new steady state in the control of thyroid hormones secretion rate. However, at 37°C, the TSH-thyroxine interrelationships seem to break down.

Effect of peptide nicking in the human chorionic gonadotropin β-subunit on stimulation of recombinant human thyroid-stimulating hormone receptors

1994 ◽  
Vol 130 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Masayoshi Yoshimura ◽  
A Eugene Pekary ◽  
Xuan-Ping Pang ◽  
Loretta Berg ◽  
Laurence A Cole ◽  
...  
Keyword(s):  
Los Angeles ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hormone Receptors ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
Β Subunit ◽  
Trophoblastic Diseases ◽  
Thyrotropic Activity ◽  
Stimulating Hormone

Yoshimura M, Pekary AE, Pang X-P, Berg L, Cole LA, Kardana A, Hershman JM. Effect of peptide nicking in the human chorionic gonadotropin β-subunit on stimulation of recombinant human thyroid-stimulating hormone receptors. Eur J Endocrinol 1994;130:92–6. ISSN 0804–4643 It is now generally accepted that human chorionic gonadotropin (hCG) has thyroid-stimulating activity. Heterologous forms of the hCG molecule occur in the purified preparations extracted from urine of pregnant women and patients with trophoblastic diseases. This work was undertaken to determine the effect of peptide nicking in the hCG-β subunit on its thyrotropic potency. Using Chinese hamster ovary cells expressing functional human thyroid-stimulating hormone (TSH) receptors, we examined the effect of nicked hCG on cyclic AMP (cAMP) production and receptor binding. The effect of human leukocyte elastase (hLE), a nicking enzyme, on standard hCG also was examined in the cAMP assay and on receptor binding. We studied five hCG preparations extracted from the urine of normal pregnancy (CR-127 and P8) and trophoblastic diseases (C2, C5 and M4). Two preparations (C2, 96% nicked and M4, 100% nicked in the β44–49 region) showed about a 1.5-fold potency of standard hCG CR-127, which is also 20% nicked in the same region. Non-nicked hCG (P8) had the weakest potency among all of the samples tested. Treatment of standard hCG with hLE increased the cAMP response about two-fold. Dose-dependent displacement of bovine [125I]TSH by standard hCG and hLE-digested hCG was observed and was almost identical. We have confirmed the increased in vitro thyrotropic activity of hCG nicked in the β-intercysteine loop on recombinant human TSH receptors. These data suggest that peptide heterogeneity of the hCG molecule may modulate the in vivo thyrotropic activity of hCG in pregnant women and patients with trophoblastic diseases. Jerome M Hershman, Endocrinology-W111D, West Los Angeles VA Medical Center, Los Angeles, California 90073, USA

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