INTRAVENOUS AND PERORAL TRH STIMULATION IN SPORADIC ATOXIC GOITRE

1977 ◽  
Vol 85 (3) ◽  
pp. 508-514 ◽  
Author(s):  
C. Kirkegaard ◽  
J. Faber ◽  
T. Friis ◽  
U. Birk Lauridsen ◽  
P. Rogowski ◽  
...  
Keyword(s):  
High Frequency ◽  
Diagnostic Value ◽  
Stimulation Test ◽  
Trh Test ◽  
Thyrotrophin Releasing Hormone ◽  
Normal Thyroid ◽  
Releasing Hormone ◽  
Trh Stimulation ◽  
Significant Difference ◽  
Bovine Tsh

ABSTRACT Thyrotrophin releasing hormone (TRH) stimulation test with 200 μg iv was performed in 35 patients with atoxic sporadic goitre. In 23 patients with diffuse goitre 7 showed a lack of increase in serum thyrotrophin (TSH) at a significantly increased frequency compared to controls (P = 0.0028). In 4 patients with solitary nodules 2 showed no significant response to TRH (negative), while 3 of the 8 patients with multinodular goitres had negative TRH test. Only 6 of the 12 TRH negative patients also had non-suppressible 131I uptake following T3. No significant difference in age and thyroid parameters was found between the TRH negative and TRH positive patients. In 7 TRH negative patients the test was repeated with 400 μg TRH but all remained negative. Five of these patients were given TRH perorally 80 mg daily for 2 weeks resulting in a significant increase in serum T4 and T3. No detectable increase in TSH was found. The response to iv bovine TSH in 4 TRH negative patients was found to be normal, suggesting that there was normal thyroid sensitivity to TSH. Our findings suggest that patients with TRH negative atoxic goitre can release biological active TSH following prolonged TRH stimulation. The high frequency of a negative standard TRH test in atoxic goitre seems to diminish the diagnostic value of the standard TRH test.

THYROID NODULE AUTONOMY: ITS DEMONSTRATION BY THE THYROTROPHIN RELEASING HORMONE (TRH) STIMULATION TEST

1973 ◽  
Vol 73 (4) ◽  
pp. 689-699 ◽  
Author(s):  
Bengt E. Karlberg
Keyword(s):  
Thyroid Function ◽  
Thyroid Nodules ◽  
Close Correlation ◽  
Stimulation Test ◽  
Assay Method ◽  
Control Group ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Trh Stimulation ◽  
Thyroid Adenomas

ABSTRACT The response of thyrotrophin (TSH) to a single iv stimulation test with synthetic thyrotrophin releasing hormone (TRH) was compared with a thyroxine (T4)suppression test including thyroid scintiscans in 23 patients with palpable single thyroid nodules and in a control group of subjects without thyroid disease. In 16 patients with toxic adenomas and clinical hyperthyroidism no TSH-response to TRH was found as well as lack of suppression of the radioiodine uptake after T4. Thyroid scintiscans remained unchanged. Seven patients, judged to be euthyroid by clinical examination and laboratory tests, also showed no suppression by T4, as well as unchanged scintiscans. Six out of these seven patients had an absent TSH response to TRH, one had a "blunted" response. These patients were classified as having autonomously functioning thyroid adenomas. Thus there was a close correlation between absent TSH-response to TRH and non-suppressibility by T4 and it is concluded that in patients with single thyroid nodules, autonomous thyroid function can be demonstrated by the simple iv TRH stimulation test (potential hyperthyroidism or preclinical hyperthyroidism). The possibility of an altered T3/T4-secretion ratio in the development of abnormal thyroid function in thyroid adenomas is discussed. It is suggested that the rapid iv TRH stimulation test is preferable to suppression tests as a screening test for the assessment of abnormal thyroid function in patients with single thyroid nodules, providing that a reliable TSH assay method is available.

scholarly journals Can Endocrine Dysfunction Be Reliably Tested in Aged Horses That Are Experiencing Pain?

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1426
Author(s):  
Heidrun Gehlen ◽  
Nina Jaburg ◽  
Roswitha Merle ◽  
Judith Winter
Keyword(s):  
Underlying Disease ◽  
Pain Scale ◽  
Stimulation Test ◽  
Pars Intermedia ◽  
Moderate Pain ◽  
Disease Group ◽  
Trh Stimulation ◽  
Significant Difference ◽  
Acth Concentration ◽  
Group 2

The aim of the present study was to evaluate (i) the effects of different intensities and types of treated pain on the basal concentrations of adrenocorticotropic hormone (ACTH) and cortisol, and (ii) the thyrotropin-releasing hormone (TRH) stimulation test, to determine whether treated pain caused a marked increase of ACTH, which would lead to a false positive result in the diagnosis of pituitary pars intermedia dysfunction (PPID). Methods: Fifteen horses with treated low to moderate pain intensities were part of the study. They served as their own controls as soon as they were pain-free again. The horses were divided into three disease groups, depending on their underlying disease (disease group 1 = colic, disease group 2 = laminitis, disease group 3 = orthopedic problems). A composite pain scale was used to evaluate the intensity of the pain. This pain scale contained a general part and specific criteria for every disease. Subsequently, ACTH and cortisol were measured before and after the intravenous application of 1 mg of TRH. Results: There was no significant difference in the basal or stimulated ACTH concentration in horses with pain and controls, between different pain intensities or between disease groups. Descriptive statistics, however, revealed that pain might decrease the effect of TRH on the secretion of ACTH. There was an increase of ACTH 30 min after TRH application (p = 0.007) in the treated pain group, but this difference could not be statistically confirmed. Measuring the basal ACTH concentration and performing the TRH stimulation test for the diagnosis of PPID seem to be possible in horses with low to moderate pain.

Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers

1989 ◽  
Vol 19 (1) ◽  
pp. 69-77 ◽  
Author(s):  
R. Hunter ◽  
J. E. Christie ◽  
L. J. Whalley ◽  
J. Bennie ◽  
S. Carroll ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Thyroid Stimulating Hormone ◽  
Thyrotrophin Releasing Hormone ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Trh Stimulation ◽  
The Status ◽  
Hormone Responses ◽  
Independent Features ◽  
Stimulating Hormone

SynopsisThe endocrine responses to Luteinizing Hormone Releasing Hormone (LHRH) of eight drug-free males with mania were determined. Basal levels of Luteinizing Hormone (LH) and the plasma levels following injection of LHRH were elevated in patients compared with controls; Follicle Stimulating Hormone (FSH) and testosterone were not different. Elevated levels of LH have been described previously in recovered manic patients and have been suggested to be state-independent features of mania. In order to clarify the status of this finding, the effects of lithium administration upon hormone responses to LHRH in six male volunteers were also investigated, together with the effects upon Thyrotrophin Releasing Hormone (TRH) stimulation of Thyroid Stimulating Hormone (TSH) and prolactin release. Lithium increased the basal levels of LH and levels after injection of LHRH without effect upon FSH and testosterone. Lithium also increased basal and TRH stimulated release of TSH and basal prolactin levels. Lithium was without effect upon prolactin responses to TRH. The results are discussed in relation to current information on the mechanism of lithium's action. The implications for neuroendocrine work on recovered patients taking lithium are also explored.

Preliminary study of thyrotrophin releasing hormone stimulation test in chronic low back pain patients

Pain ◽  
1986 ◽  
Vol 27 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Randal D. France ◽  
K. Ranga ◽  
R. Krishnan ◽  
Veeraindar Goli ◽  
Ananth N. Manepalli ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Stimulation Test ◽  
Low Back ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Stimulation ◽  
Preliminary Study ◽  
Pain Patients

Combined pyridostigmine–thyrotrophin-releasing hormone test for the evaluation of hypothalamic somatostatinergic activity in healthy normal men

1995 ◽  
Vol 133 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Inmyung Yang ◽  
Jeongtaek Woo ◽  
Sungwoon Kim ◽  
Jinwoo Kim ◽  
Youngseol Kim ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Growth Hormone ◽  
Large Dose ◽  
Trh Test ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
School Of Medicine ◽  
Prolactin Response ◽  
Normal Men ◽  
Different Doses

Yang I, Woo J, Kim S, Kim J, Kim Y, Choi Y. Combined pyridostigmine–thyrotrophin-releasing hormone test for the evaluation of hypothalamic somatostatinergic activity in healthy normal men. Eur J Endocrinol 1995;133:457–62. ISSN 0804–4643 Pyridostigmine (PST), a cholinesterase inhibitor, induces a clear growth hormone (GH) release in man by suppression of hypothalamic somatostatin (SRIH). Somatostatin suppresses thyrotrophin (TSH) release in rats and men. Earlier studies showed that the thryotrophin-releasing hormone (TRH)-induced TSH response was not altered by 60–120 mg of PST. We studied whether a larger dose (180 mg) of PST can increase the TSH response to TRH. Six healthy young men were studied with the following six tests: (Test 1) 200 μg of TRH iv; (Test 2) 180 mg of PST po; (Test 3) three different doses of PST (60, 120, 180 mg) + TRH; (Test 4) 100 μg of octreotide (SMS) iv; (Test 5) SMS + TRH; (Test 6) PST + SMS + TRH. A large dose of PST (180 mg) significantly augmented GH, TSH and prolactin responses to TRH, while smaller doses of PST (60 and 120 mg) did not significantly increase the responses of GH and TSH. While the increased TRH-induced prolactin response by PST was not suppressed by SMS, the increased responses of GH and TSH were suppressed remarkably by SMS. Most of the subjects noticed a mild to moderate abdominal pain, nausea and muscular fasciculation after the administration of a large dose of PST administration. These data suggest that suppression of hypothalamic SRIH secretion by 180 mg of PST can augment the TSH response to TRH. However, the considerable side effects should be minimized before clinical application of the combined PST–TRH test. Inmyung Yang, Division of Endocrinology, Department of Internal Medicine, Kyunghee University School of Medicine, 1 Hoiki-dong, Dongdaemoon-ku, Seoul, 130–702, Korea

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