SECRETION OF THYROXINE, 3,5,3′-TRIIODOTHYRONINE AND 3,3′5′-TRIIODOTHYRONINE IN EUTHYROID MAN

1977 ◽  
Vol 84 (2) ◽  
pp. 281-289 ◽  
Author(s):  
U. Westgren ◽  
A. Melander ◽  
S. Ingemansson ◽  
A. Burger ◽  
S. Tibblin ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Venous Blood ◽  
Human Thyroid ◽  
Acute Administration ◽  
Peripheral Venous Blood ◽  
Before And After ◽  
Normal Human ◽  
Pre Treatment ◽  
Almost All ◽  
Secretion Rates

ABSTRACT The secretion of iodothyronines from the normal human thyroid gland was assessed by radioimmunoassay analyses of the concentrations of thyroxine (T4), 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (reverse T3, rT3) in thyroid venous and peripheral venous blood. The subjects studied were euthyroid patients undergoing parathyroid surgery. Measurements were carried out both under apparently normal conditions, following peroral T3 pre-treatment, and before and after acute administration of TSH into a thyroid artery. In the control subjects, significant gradients between thyroid venous and peripheral venous concentrations were recorded both for T4, T3 and rT3, suggesting that all three iodothyronines are secreted by the normal human thyroid. T3 pre-treatment seemed to reduce this secretion, and acute administration of TSH promoted rapid, marked, and concomitant increments in the thyroid venous concentrations of all three iodothyronines. Hence, it appears that not only T4 but also T3 and rT3 are secreted by the normal human thyroid gland, and that TSH stimulates the secretion of all three iodothyronines. On the other hand, calculations of the relative secretion rates yielded the relation T4:T3:rT3 as 85:9:1. This indicates that, in euthyroid subjects, most of T3, and almost all of rT3, is produced by extrathyroidal conversion of T4 and not by direct thyroidal secretion.

Failure of exogenous secretin to induce secretion of calcitonin in man

1983 ◽  
Vol 103 (3) ◽  
pp. 355-358 ◽  
Author(s):  
Mats Ericsson ◽  
Bertel Berg ◽  
Stig Ingemansson ◽  
Bertil Månsson ◽  
Anders Nobin
Keyword(s):  
Thyroid Gland ◽  
Calcium Level ◽  
Venous Blood ◽  
Human Thyroid ◽  
Parathyroid Surgery ◽  
Peripheral Vein ◽  
Blood Samples ◽  
Peripheral Venous Blood ◽  
Calcitonin Secretion ◽  
Different Doses

Abstract. The effect of secretin on calcitonin secretion from the human thyroid gland was studied in 15 patients undergoing thyroid and parathyroid surgery. Secretin was administered into the inferior thyroid artery at two different doses (0.75 and 7.5 CU) and into a peripheral vein at a dose of 75 CU. Blood samples for measurements of calcitonin and calcium were collected from thyroid or peripheral veins. However, neither intraarterially nor iv administered secretin was able to evoke any significant calcitonin response as measured in thyroid or peripheral venous blood. The calcium level was unaffected by secretin. The results demonstrate that secretin does not act as a calcitonin secretagogue in man.

Aminophylline and human diaphragm strength in vivo

1990 ◽  
Vol 68 (6) ◽  
pp. 2591-2596 ◽  
Author(s):  
R. D. Levy ◽  
S. Nava ◽  
L. Gibbons ◽  
F. Bellemare
Keyword(s):  
Motor Units ◽  
Normal Subjects ◽  
Acute Administration ◽  
Transdiaphragmatic Pressure ◽  
Gastric Pressure ◽  
Significant Difference ◽  
Before And After ◽  
Normal Human ◽  
Twitch Characteristics

The transdiaphragmatic pressure (Pdi) twitch response to single shocks from supramaximal bilateral phrenic nerve stimulation was studied before and after acute intravenous infusions of aminophylline [14.9 +/- 3.1 (SD) micrograms/ml] in nine normal subjects. Stimulation was performed with subjects in the sitting position against an occluded airway from end expiration. Baseline gastric pressure and abdominal and rib cage configuration were kept constant. There was no significant difference in peak twitch Pdi from the relaxed diaphragm between control (38.8 +/- 3.3 cmH2O) and aminophylline (40.2 +/- 5.2 cmH2O) experiments. Other twitch characteristics including contraction time, half-relaxation time, and maximum relaxation rate were also unchanged. The Pdi-twitch amplitude at different levels of voluntary Pdi was measured with the twitch occlusion technique, and this relationship was found to be similar under control conditions and after aminophylline. With this technique, maximum Pdi (Pdimax) was calculated as the Pdi at which stimulation would result in no Pdi twitch because all motor units are already maximally activated. No significant change was found in mean calculated Pdimax between control (146.9 +/- 27.0 cmH2O) and aminophylline (149.2 +/- 26.0 cmH2O) experiments. We conclude from this study that the acute administration of aminophylline at therapeutic concentrations does not significantly affect contractility or maximum strength of the normal human diaphragm in vivo.

Influence of Perchlorate on the Secretion of Non-Thyroxine Iodine by the Normal Human Thyroid Gland

1974 ◽  
Vol 4 (1) ◽  
pp. 65-69 ◽  
Author(s):  
H. Bürgi ◽  
M. Benguerel ◽  
J. Knopp ◽  
H. Kohler ◽  
H. Studer
Keyword(s):  
Thyroid Gland ◽  
Human Thyroid ◽  
Normal Human

FORMATION OF EPITESTOSTERONE BY HUMAN BLOOD AND ADRENAL TISSUE

1967 ◽  
Vol 54 (2) ◽  
pp. 208-214 ◽  
Author(s):  
Jorge Blaquier ◽  
Ralph I. Dorfman ◽  
Enrico Forchielli
Keyword(s):  
Venous Blood ◽  
Endocrine Gland ◽  
Men And Women ◽  
Peripheral Venous Blood ◽  
Adrenal Tissue ◽  
Idiopathic Hirsutism ◽  
Normal Human ◽  
Normal Men ◽  
Peripheral Production

ABSTRACT Whole peripheral venous blood from normal men and women, and from females with idiopathic hirsutism was incubated in vitro with labelled testosterone, androstenedione and dehydroepiandrosterone. Epitestosterone was formed consistently from added testosterone, in some cases from androstenedione but not from dehydroepiandrosterone. The rate of formation of epitestosterone from testosterone by blood of normal men and women is similar, whereas the rate of formation in blood from female idiopathic hirsutes was several fold greater. In a similar manner, normal human adrenal tissue also formed epitestosterone from added testosterone but not from androstenedione nor dehydroepiandrosterone. These results suggest that the origin of urinary epitestosterone can be the resultant of both peripheral production and endocrine gland secretion.

Expression of galectin-1 in normal human thyroid gland and in differentiated and poorly differentiated thyroid tumors

1995 ◽  
Vol 64 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Lorenzo Chiariotti ◽  
Maria Teresa Berlingieri ◽  
Caterina Battaglia ◽  
Giovanna Benvenuto ◽  
Maria Luisa Martelli ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Human Thyroid ◽  
Thyroid Tumors ◽  
Normal Human ◽  
Poorly Differentiated

PLASMA PROGESTERONE LEVELS IN GOATS DURING PREGNANCY MEASURED BY COMPETITIVE PROTEIN BINDING

1971 ◽  
Vol 66 (3) ◽  
pp. 471-477 ◽  
Author(s):  
Anne Kristine Blom ◽  
Olav Lyngset
Keyword(s):  
Protein Binding ◽  
Uterine Artery ◽  
Venous Blood ◽  
Ovarian Vein ◽  
Progesterone Concentration ◽  
Gradual Decline ◽  
Plasma Progesterone ◽  
Peripheral Venous Blood ◽  
Before And After ◽  
Competitive Protein Binding

ABSTRACT Plasma progesterone concentration at different stages of pregnancy was measured in the blood obtained from the uterine artery (6 goats), the uterine vein (6 goats), and the ovarian vein (11 goats). Progesterone concentration was also measured in the peripheral venous blood before and after extirpation of the ovaries and the uterus (16 goats). The concentration of progesterone was found to rise gradually in the peripheral and ovarian vein blood to reach a maximum at 90 days of pregnancy. This was followed by a gradual decline with consistent low values of about 7 ng prog./ml 3–4 days before parturition. A significant decrease in peripheral progesterone concentration was found 10 minutes after removing the ovaries and the uterus. In two goats sampled before and after parturition, the plasma progesterone concentration was found to decrease before parturition and to remain low for at least three days after parturition.

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