THYROGLOBULIN IN SERUM AFTER TSH STIMULATION IN HYPERTHYROIDISM

1974 ◽  
Vol 75 (4) ◽  
pp. 699-706 ◽  
Author(s):  
T. Hjort ◽  
Th. Friis ◽  
U. Birk Lauridsen ◽  
I. Persson
Keyword(s):  
Thyroid Gland ◽  
Haemagglutination Inhibition ◽  
Serum Thyroxine ◽  
Thyroglobulin Antibody ◽  
Thyroglobulin Level ◽  
Inhibition Technique ◽  
Hyperthyroid Patients ◽  
Tsh Stimulation

ABSTRACT Thyroglobulin in serum was demonstrated by a haemagglutination-inhibition technique and a reversed haemagglutination technique. Circulating thyroglobulin was found in 12 of 15 hyperthyroid patients – both before and during treatment with methylthiouracil – but in none of 12 euthyroid subjects. In three hyperthyroid patients it was not possible to determine thyroglobulin, as thyroglobulin antibody was present in the serum. After TSH stimulation thyroglobulin appeared in the serum of nine of the 12 euthyroid subjects and the thyroglobulin level increased in five of the 12 untreated and six of the 12 treated hyperthyroid patients. The serum thyroxine, T3 uptake in resin and 131I uptake in the thyroid gland at 4 and 24 h were increased after TSH stimulation in all the euthyroid cases; the hyperthyroid patients (both before and during treatment), however, only showed a slight but significant increase in serum thyroxine and 4 h 131I uptake, while the T3 uptake in resin and the 24 h 131I uptake did not rise at all. LATS was found in serum of only five of 15 untreated hyperthyroid patients. No significant changes in the LATS content could be detected during treatment. The increased content of thyroglobulin in the serum of hyperthyroid patients seems to be due neither to greater sensitivity to TSH nor to the influence of LATS.

THE ROLE OF MELATONIN IN THE REGULATION OF THYROTROPHIN SECRETION

1968 ◽  
Vol 57 (3) ◽  
pp. 363-373 ◽  
Author(s):  
J. N. Panda ◽  
C. W. Turner ◽  
Mary Powell
Keyword(s):  
Thyroid Gland ◽  
Marked Decrease ◽  
Haemagglutination Inhibition ◽  
Regulatory Effect ◽  
Hormone Synthesis ◽  
Thyroid Glands ◽  
Tsh Secretion ◽  
The Mean ◽  
Inhibition Technique

ABSTRACT The fact that melatonin, a pineal substance, causes a depression in thyroid function of prepuberal rats has been reported. A possible site of this action on the thyroid gland has been studied by estimating the TSH content of blood and hypophysis in rats from 35 days to 65 days of age. Haemagglutination-inhibition technique has been used to assay very small amounts of TSH in plasma. Rats receiving 100 μg of melatonin daily for 10 days were sacrificed at 35, 45, 55 and 65 days of age. The mean thyroid weight of each group was markedly higher than that of the corresponding controls. The plasma TSH/ml level was higher in experimental groups, with a marked decrease (0.10 > P > 0.05) in TSH/mg of hypophysis (wet), especially at 45 and 55 days of age. Rats similarly treated with 400 μg/100 g body weight of tapazole daily for 10 days and sacrificed at 45 and 55 days of age showed higher plasma and lower hypophyseal TSH levels than the controls and the results were comparable to those of the melatonin treated groups. The dry-fat-free tissue of the thyroid glands of the melatonin treated groups were higher than the corresponding controls and their DNA content was significantly higher (0.050 > P > 0.025) also, indicating hyperplasia and hypertrophy of the thyroid glands resulting from the action of melatonin. The histological picture of the melatonin treated animals showed goitrogenic effect. It may be concluded from these data that melatonin exerts its regulatory effect on TSH secretion directly acting on the thyroid gland and in some way inhibiting thyroid hormone synthesis or release.

Compensated 131I-therapy of solitary autonomous thyroid nodules: effect on thyroid size and early hypothyroidism

1986 ◽  
Vol 113 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Laszlo Hegedüs ◽  
Dagmar Veiergang ◽  
Steen Karstrup ◽  
Jens Mølholm Hansen
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Nodules ◽  
Thyroid Volume ◽  
131I Therapy ◽  
Important Place ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
One Year ◽  
Hyperthyroid Patients

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

Iodide Metabolism and Effects

2020 ◽  
pp. 25-33
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Dietary Supplement ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Hormone Synthesis ◽  
Serum Tsh ◽  
Tsh Stimulation ◽  
Sensitive Marker

Iodine (I2) is essential in the synthesis of thyroid hormones T4 and T3 and functioning of the thyroid gland. Both T3 and T4 are metabolically active, but T3 is four times more potent than T4. Our body contains 20-30 mg of I2, which is mainly stored in the thyroid gland. Iodine is naturally present in some foods, added to others, and available as a dietary supplement. Serum thyroid stimulating hormone (TSH) level is a sensitive marker of thyroid function. Serum TSH is increased in hypothyroidism as in Hashimoto's thyroiditis. In addition to regulation of thyroid function, TSH promotes thyroid growth. If thyroid hormone synthesis is chronically impaired, TSH stimulation eventually may lead to the development of a goiter. This chapter explores the iodide metabolism and effects of Hashimoto's disease.

Thyroid Diseases

2019 ◽  
pp. 62-64
Author(s):  
Kevin B. Hoover
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Treatment Options ◽  
Normal Function ◽  
Thyroid Diseases ◽  
Hormone Levels ◽  
Musculoskeletal Manifestations ◽  
Hyperthyroid Patients ◽  
Serum Testing ◽  
Radioactive Iodine Ablation

Chapter 81 discusses thyroid diseases. Thyroid hormone is a regulator of normal physiology, including normal function of the musculoskeletal system. The most important causes of both elevated thyroid hormone levels (hyperthyroidism) and decreased hormone levels (hypothyroidism) are diseases of the thyroid gland. These are primarily diagnosed using serum testing and thyroid imaging. Muscle weakness is a common musculoskeletal complaint in both hyperthyroidism and hypothyroidism. In adults, osteoporosis is often evaluated in hyperthyroid patients using DXA, however, other musculoskeletal manifestations are often incidentally detected. Treatment options include radioactive iodine ablation of the thyroid gland, medical therapy, and surgery.

Effects of antiserum containing thyroglobulin antibody on the chicken thyroid gland

1978 ◽  
Vol 10 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Jan Jaroszewski ◽  
Roy S. Sundick ◽  
Noel R. Rose
Keyword(s):  
Thyroid Gland ◽  
Thyroglobulin Antibody

A Comparison of Serum Thyroxine [T4(D)], RT3U Ratio and T4-RT3 Index with Radioiodine Uptake in the TSH Stimulation Test

1972 ◽  
Vol 11 (04) ◽  
pp. 324-332
Author(s):  
R. Höschl ◽  
T. M. D. Gimlette
Keyword(s):  
Free Thyroxine ◽  
Stimulation Test ◽  
Radioiodine Uptake ◽  
Serum Thyroxine ◽  
Positive Serum ◽  
Free Thyroxine Index ◽  
Reliable Parameter ◽  
Stimulation Tests ◽  
Tsh Stimulation ◽  
Better Than

SummaryA total of 236 TSH stimulation tests were performed using 10 units of TSH intramuscularly. 4 hour uptake of 132I, serum thyroxine [T4(D)], T3 binding coefficient [RT3U ratio] and free thyroxine index [T4-RT3 index] were estimated before and 18 hours after TSH.In 88 tests classified by radioiodine uptake change as positive serum thyroxine increased significantly in only 63.7%, T4-RT3 index in 61.5%.Out of 108 tests classified as negative by radioiodine uptake, serum thyroxine increased significantly in 14.8% and T4-RT3 index in 13.0%.The RT3U ratio procedure used was the least reliable parameter in testing thyroid response to TSH stimulation, T4RT3 index was no better than T4(D) alone.The change in serum thyroxine levels in response to TSH stimulation is in our opinion unreliable for the evaluation of TSH tests, and correlates poorly with changes in radioiodine uptake (r = 0.37), for reasons which are discussed.

A Rapid Turbidimetric Determination of Fibrinogen Degradation Products (FDP)

1978 ◽  
Vol 39 (01) ◽  
pp. 012-021 ◽  
Author(s):  
H W Verbruggen ◽  
J M C Wessels
Keyword(s):  
Human Serum ◽  
Degradation Products ◽  
Haemagglutination Inhibition ◽  
Serum Samples ◽  
Fibrinogen Degradation Products ◽  
Turbidimetric Method ◽  
Antigen Antibody ◽  
Inhibition Technique

SummaryA rapid and simple turbidimetric determination of fibrinogen degradation products is described. This method is based on the increase of the turbidity due to the formation of precipitating antigen-antibody complexes after addition of rabbit antihuman fibrinogen antiserum to human serum. The increase in turbidity correlates very well with results obtained with the haemagglutination inhibition technique and has the advantage of a more objective quantitation. The reproducibility appears to be quite good. The turbidimetric method is independent of the colour of serum samples.

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