PLASMA RENIN ACTIVITY DURING THE NORMAL MENSTRUAL CYCLE

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S160 ◽  
Author(s):  
H. Kaulhausen ◽  
W. Oehm ◽  
H. Breuer
Keyword(s):  
Menstrual Cycle ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Normal Menstrual Cycle

PLASMA RENIN ACTIVITY, PLASMA RENIN SUBSTRATE AND URINARY ALDOSTERONE EXCRETION IN THE MENSTRUAL CYCLE IN RELATION TO THE CONCENTRATION OF PROGESTERONE AND OESTROGENS IN THE PLASMA

1972 ◽  
Vol 71 (3) ◽  
pp. 519-529 ◽  
Author(s):  
Johan A. Sundsfjord ◽  
A. Aakvaag
Keyword(s):  
Menstrual Cycle ◽  
Plasma Renin Activity ◽  
Luteal Phase ◽  
Plasma Renin ◽  
Renin Activity ◽  
Renin Substrate ◽  
Plasma Progesterone ◽  
Failure Group ◽  
Normal Menstrual Cycle ◽  
Normal Increase

ABSTRACT The relative importance of endogenous progesterone and oestrogens on the rise in plasma renin activity and urinary aldosterone excretion in the luteal phase of the menstrual cycle has been investigated in two groups of young women. One group (luteal group) had plasma progesterone levels of 7–19.5 ng/ml (mean 12.3; sem 1.3) in the second half of the cycle. The other group (luteal failure group) had plasma progesterone levels of 1.5–3.0 ng/ml, (mean 2.1; sem 0.16), on the corresponding days in the second half of the cycle. The plasma oestrogen levels and the oestriol excretion did not differ between the groups at any stage of the cycle. In the luteal group the normal increase in plasma progesterone and plasma oestrogens and in oestriol excretion was accompanied by a doubling in plasma renin activity and urinary aldosterone excretion, whereas the plasma renin substrate levels did not change significantly. In the luteal failure group, no significant increase was found in either plasma renin activity or in urinary aldosterone excretion, in spite of the unchanged plasma oestrogen levels and oestriol excretion. In this group too the plasma renin substrate levels showed no change from the first to the second half of the cycle. It is concluded that the rise in plasma renin activity, plasma angiotensin II concentration and urinary aldosterone excretion in the luteal phase of the normal menstrual cycle is caused by increased progesterone production.

Ambulatory Blood Pressure Changes in the Menstrual Cycle of Hypertensive Women Significance of Plasma Renin Activity Values

1993 ◽  
Vol 6 (8) ◽  
pp. 654-659 ◽  
Author(s):  
Eva A. Karpanou ◽  
Gregory P. Vyssoulis ◽  
Dorita G. Georgoudi ◽  
Marina G. Toutouza ◽  
Pavlos K. Toutouzas
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Plasma Renin Activity ◽  
Ambulatory Blood Pressure ◽  
Plasma Renin ◽  
Renin Activity ◽  
Pressure Changes

RADIOIMMUNOLOGICAL DETERMINATION OF PLASMA RENIN ACTIVITY DURING THE MENSTRUAL CYCLE AND DURING ACUTE PROGESTERONE ADMINISTRATION

1971 ◽  
Vol 67 (1) ◽  
pp. 174-186 ◽  
Author(s):  
Johan A. Sundsfjord
Keyword(s):  
Menstrual Cycle ◽  
Plasma Renin Activity ◽  
Limit Of Detection ◽  
Plasma Renin ◽  
Renin Activity ◽  
Angiotensin I ◽  
Sephadex Column ◽  
Radioimmunological Determination ◽  
Iodine 125

ABSTRACT Antibodies to ileu5angiotensin I were produced in rabbits with the poly-l-lysine succinyl complex of angiotensin I. Iodine-125 was used for the labelling of angiotensin I. The tracer was purified on a G-15 Sephadex column. For the determination of plasma renin activity plasma samples containing EDTA and BAL were incubated for two hours at 37°C. while a parallel sample was kept at 4°C to serve as a plasma blank. The angiotensin I content in 50 μl of plasma diluted 1:20 was quantitated directly, without prior extraction. For the immunoassay the samples and standards were incubated with 125I-angiotensin I (about 2500 cpm) and antiserum at a final dilution of 1:50 000–1:60 000 for 16–18 hours at 4°C. Dextran-coated charcoal was used for the separation of free and antibody-bound angiotensin I. The antiserum did not bind angiotensin II. The lower limit of detection was 20 pg. An average recovery of added angiotensin I of 100.5 % ± 11 (sd) was obtained. In duplicate determinations a coefficient of variation of 6.9 % was found. The method was used to measure renin activity during the menstrual cycle. In the follicular phase a range of 0.8–1.5, mean 1.14 ng ang.I/ml/h, was found, whereas the values in the luteal phase were 2.1–4.0, mean 3.06 ng ang.I/ml/h, respectively. When 500 mg progesterone, divided into 5 doses over a period of 24 hours was given to menopausal women, an increase in renin activity was found. No increase in aldosterone excretion or in the K/Na ratio in the urine was observed during this period.

VARIATIONS IN PLASMA ALDOSTERONE AND PLASMA RENIN ACTIVITY THROUGHOUT THE MENSTRUAL CYCLE, WITH SPECIAL REFERENCE TO THE PRE-OVULATORY PERIOD

1973 ◽  
Vol 73 (3) ◽  
pp. 499-508 ◽  
Author(s):  
Johan A. Sundsfjord ◽  
A. Aakvaag
Keyword(s):  
Menstrual Cycle ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Blocking Agent ◽  
Plasma Aldosterone ◽  
Renin Activity ◽  
Renin Substrate ◽  
Specific Radioimmunoassay ◽  
Early Follicular Phase ◽  
Ovulatory Period

ABSTRACT The day to day variations in plasma aldosterone and plasma renin activity throughout the menstrual cycle have been investigated in healthy young women. A sensitive and specific radioimmunoassay for the measurement of plasma aldosterone is described. The actual hormone parameters have been correlated with fluctuations in plasma oestradiol and progesterone, and LH has been measured for the determination of time of ovulation. Plasma renin activity and plasma aldosterone gradually increased two to four times from the early follicular to the mid-luteal phase, in accordance with earlier observations. In one woman using a beta adrenergic blocking agent plasma renin activity rose only slightly, whereas a normal rise in plasma aldosterone was noted. Another woman became pregnant during the cycle investigated. In this subject neither plasma renin activity nor plasma aldosterone decreased at the end of the cycle. Plasma aldosterone was almost doubled on the pre-ovulatory day, as compared with the early follicular phase, whereas no significant change in plasma renin activity or plasma renin substrate was found. The cause of this pre-ovulatory increase in plasma aldosterone is not known.

VARIATIONS IN PLASMA RENIN ACTIVITY AND URINARY ALDOSTERONE EXCRETION IN NORMAL SUBJECTS AFTER SALT RESTRICTION AND ACUTE PITUITARY INHIBITION WITH 6-DEHYDRO-16-METHYLENE HYDROCORTISONE

1971 ◽  
Vol 67 (1) ◽  
pp. 159-173
Author(s):  
A. Peytremann ◽  
R. Veyrat ◽  
A. F. Muller
Keyword(s):  
Plasma Renin Activity ◽  
Salt Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Inhibitory Effect ◽  
Renin Activity ◽  
Sodium Balance ◽  
Experimental Conditions ◽  
Salt Restriction ◽  
Aldosterone Production

ABSTRACT Variations in plasma renin activity and urinary aldosterone excretion were studied in normal subjects submitted to salt restriction and simultaneous inhibition of ACTH production with a new synthetic steroid, 6-dehydro-16-methylene hydrocortisone (STC 407). At a dose of 10 mg t. i. d. this preparation exerts an inhibitory effect on the pituitary comparable to that of 2 mg of dexamethasone. In subjects maintained on a restricted salt intake, STC 407 does not delay the establishment of an equilibrium in sodium balance. The increases in endogenous aldosterone production and in plasma renin activity are also similar to those seen in the control subjects. A possible mineralocorticoid effect of STC 407 can be excluded. Under identical experimental conditions, the administration of dexamethasone yielded results comparable to those obtained with STC 407.

Sign in / Sign up

Export Citation Format

Share Document