COMPARATIVE STUDIES ON THE METABOLIC EFFECTS OF SOME PARAMETERS OF CARBOHYDRATE AND LIPID METABOLISM AFTER INTRAVENOUS ADMINISTRATION OF HUMAN PLACENTAL LACTOGEN, HUMAN PROLACTIN AND GROWTH HORMONE

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S104 ◽  
Author(s):  
P. Berle
Keyword(s):  
Growth Hormone ◽  
Lipid Metabolism ◽  
Intravenous Administration ◽  
Comparative Studies ◽  
Metabolic Effects ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Carbohydrate And Lipid Metabolism ◽  
Human Prolactin

scholarly journals Recombinant hormones from fragments of human growth hormone and human placental lactogen.

1981 ◽  
Vol 256 (1) ◽  
pp. 296-300
Author(s):  
J. Russell ◽  
L.M. Sherwood ◽  
K. Kowalski ◽  
A.B. Schneider
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Placental Lactogen ◽  
Human Placental Lactogen

Failure of Human Growth Hormone and Human Placental Lactogen to Affect Glucose Consumption by Human Erythrocytes and Leucocytes In Vitro

1972 ◽  
Vol 50 (10) ◽  
pp. 1014-1017
Author(s):  
Catherine L. Tanser ◽  
Nannie K. M. de Leeuw
Keyword(s):  
Growth Hormone ◽  
Glucose Oxidase ◽  
Human Growth Hormone ◽  
Glucose Utilization ◽  
Human Growth ◽  
Glucose Consumption ◽  
Inhibitory Effect ◽  
Placental Lactogen ◽  
Human Placental Lactogen

The effect of human growth hormone (HGH) and human placental lactogen (HPL) on glucose consumption by erythrocytes and leucocytes in vitro was investigated. Glucose consumption was measured by determining glucose utilization during 3 h incubation at 37 °C, using the glucose oxidase method.HGH and HPL showed no effect on glucose consumption by erythrocytes, and HPL showed no effect on glucose consumption by leucocytes in vitro. Our results do not confirm previous reports of an inhibitory effect of HGH on glucose consumption by erythrocytes in vitro.

The Human Placental Lactogen and Growth Hormone Multi-Gene Family

1988 ◽  
pp. 33-57
Author(s):  
Hugo A. Barrera-Saldanña ◽  
Ramiro Ramírez-Solís ◽  
William H. Walker ◽  
Susan L. Fitzpatrick ◽  
Diana Reséndez-Pérez ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gene Family ◽  
Placental Lactogen ◽  
Human Placental Lactogen

Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?

2000 ◽  
Vol 78 (10) ◽  
pp. 829-847 ◽  
Author(s):  
Margaret C Cam ◽  
Roger W Brownsey ◽  
John H McNeill
Keyword(s):  
Lipid Metabolism ◽  
Metabolic Effects ◽  
Isolated Cells ◽  
Insulin Mimetic ◽  
Endogenous Insulin ◽  
Carbohydrate And Lipid Metabolism ◽  
Low Concentrations ◽  
Tissue Sensitivity ◽  
High Concentrations

The demonstration that the trace element vanadium has insulin-like properties in isolated cells and tissues and in vivo has generated considerable enthusiasm for its potential therapeutic value in human diabetes. However, the mechanisms by which vanadium induces its metabolic effects in vivo remain poorly understood, and whether vanadium directly mimics or rather enhances insulin effects is considered in this review. It is clear that vanadium treatment results in the correction of several diabetes-related abnormalities in carbohydrate and lipid metabolism, and in gene expression. However, many of these in vivo insulin-like effects can be ascribed to the reversal of defects that are secondary to hyperglycemia. The observations that the glucose-lowering effect of vanadium depends on the presence of endogenous insulin whereas metabolic homeostasis in control animals appears not to be affected, suggest that vanadium does not act completely independently in vivo, but augments tissue sensitivity to low levels of plasma insulin. Another crucial consideration is one of dose-dependency in that insulin-like effects of vanadium in isolated cells are often demonstrated at high concentrations that are not normally achieved by chronic treatment in vivo and may induce toxic side effects. In addition, vanadium appears to be selective for specific actions of insulin in some tissues while failing to influence others. As the intracellular active forms of vanadium are not precisely defined, the site(s) of action of vanadium in metabolic and signal transduction pathways is still unknown. In this review, we therefore examine the evidence for and against the concept that vanadium is truly an insulin-mimetic agent at low concentrations in vivo. In considering the effects of vanadium on carbohydrate and lipid metabolism, we conclude that vanadium acts not globally, but selectively and by enhancing, rather than by mimicking the effects of insulin in vivo.Key words: vanadium, insulin-mimetic, insulin-like, insulin-enhancing.

scholarly journals Biological effects of growth hormone on carbohydrate and lipid metabolism

2010 ◽  
Vol 20 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Archana Vijayakumar ◽  
Ruslan Novosyadlyy ◽  
YingJie Wu ◽  
Shoshana Yakar ◽  
Derek LeRoith
Keyword(s):  
Growth Hormone ◽  
Lipid Metabolism ◽  
Biological Effects ◽  
Carbohydrate And Lipid Metabolism
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