FOLLICLE STIMULATING HORMONE (FSH) AND INTERSTITIAL CELL STIMULATING HORMONE (ICSH) IN RELATION TO GAMETIC OUTPUT IN 643 MALES

1973 ◽  
Vol 72 (2) ◽  
pp. 243-256 ◽  
Author(s):  
Berndt Kjessler ◽  
Leif Wide
Keyword(s):  
Interstitial Cell ◽  
General Trend ◽  
Sperm Count ◽  
Male Partners ◽  
Healthy Male ◽  
Gonadotrophin Secretion ◽  
Sperm Counts ◽  
The Mean ◽  
Observation Period ◽  
Stimulating Hormone

ABSTRACT The relation between gonadotrophin secretion and average gametic output has been investigated in 643 healthy male partners of barren couples. FSH and ICSH excretion in urine were determined by means of bioassay and radioimmunoassay respectively, and FSH in serum was determined by radioimmunoassay. The mean sperm counts were calculated for each patient from serial seminal analyses over a 12 week observation period. The subjects were grouped according to their average gametic output and statistically significant differences were found between all mean excretion values for FSH, and for all but one pair of ICSH mean excretion values, when groups of patients with decreasing gametic output were compared. Individual assay results were, however, widely spread within each subgroup with extensive overlapping between the groups. A general trend towards an increase in FSH as well as of ICSH secretion with decreasing gametic output was found. Thus, the mean excretion of FSH was found to be increased by 2.7 times, and the mean excretion of ICSH by 1.7 times, when azoospermic males were compared with males with a mean sperm count of 20 mill, per ml or more. There was no evidence of accumulation of males with low or absent gonadotrophin secretion in any subgroup, and this may indicate that only few, if any, of the ordinary healthy male partners in the present couples suffered from a primary pituitary failure to secrete FSH or ICSH. About 50 per cent of the males with increased FSH secretion and low or absent gametic output may have a selective spermatogenic failure, while the remainders are likely to suffer from a more general gonadal deficiency, since they also have a concomitant rise in ICSH.

SERUM TESTOSTERONE AS AN INDEX OF GONADOTROPHIN SECRETION IN ACROMEGALY AND PITUITARY DISEASE

1970 ◽  
Vol 65 (2) ◽  
pp. 302-308 ◽  
Author(s):  
Robert L. Rosenfield ◽  
Ira D. Goldfine ◽  
A. M. Lawrence
Keyword(s):  
Interstitial Cell ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Substitution Therapy ◽  
Normal Response ◽  
Testosterone Levels ◽  
Pituitary Disease ◽  
Gonadotrophin Secretion ◽  
Lh Secretion ◽  
Stimulating Hormone

ABSTRACT Laboratory evidence for hypogonadism has been sought in 33 patients with acromegaly and pituitary disease. Low serum testosterone was found in 7 of the 15 males with acromegaly and 4 of 4 with chromophobe adenomas. Clomiphene administration caused no rise in testosterone in the acromegalic tested; a normal response to HCG, however, was determined in another. Disparity between testosterone levels and sperm count in three subjects suggests that dissociation of follicle stimulating hormone (FSH) secretion from interstitial cell stimulating hormone (LH) secretion may occur in association with hypothalamic-pituitary disease. This study indicates that gonadotrophic insufficiency is a commonly associated feature of acromegaly in the male. Testosterone levels were depressed in four of the five females with hypoadrenalism and/or hypogonadism secondary to pituitary disease who were not on oestrogen substitution therapy.

423. Effects of Eurycoma longifolia Jack on spermatogenesis and sperm counts of male rats treated with oestradiol

2008 ◽  
Vol 20 (9) ◽  
pp. 103
Author(s):  
A. Norhazlina ◽  
A. Wan Nurul Heriza ◽  
M. Norfilza ◽  
P. Moratv
Keyword(s):  
Cell Count ◽  
Sperm Count ◽  
Treated Group ◽  
Spermatogenic Cell ◽  
Male Rats ◽  
Control Group ◽  
Root Extract ◽  
Healthy Male ◽  
Eurycoma Longifolia ◽  
Sperm Counts

Eurycoma longifolia has been known for its aphrodisiac effects in male. Our previous study showed that with the dosage of 8 mg/kg bodyweight (BW) Eurycoma longifolia root extract increased plasma total testosterone levels in male rats when given for 14 days. Oestrogen is a potent inhibitor for testosterone production and spermatogenesis. The aim of the present study is to determine the effects of Eurycoma longifolia (8 mg/kg BW) on the spermatogenic cell count and sperm count of testosterone-suppressed male rats. Adult male Sprague-Dawley healthy male rats weighed 200–250 g were treated with, either control vehicle (no active ingredients given), oestradiol (500 mg/kg BW), Eurycoma longifolia (8 mg/kg BW) or combination of Eurycoma longifolia and oestradiol for fourteen consecutive days. Results showed that sperm count and spermatogenic cell count were increased in Eurycoma longifolia treated group compared with control group (P < 0.05) and to oestradiol treated group (P < 0.05). While in oestradiol treated group, sperm count and spermatogenic cell count were reduced significantly (P < 0.05) compared with control group. Combination of Eurycoma longifolia and oestradiol did not affect sperm count and spermatogenic cell count when compared with control group but they were significantly increased compared with oestradiol treated group (P < 0.05). Thus, the study has shown that Eurycoma longifolia is potentially capable to suppress harmful effects of oestradiol on spermatogenesis and sperm counts in healthy male rats when given for fourteen consecutive days.

scholarly journals Reliability of testicular stiffness quantification using shear wave elastography in predicting male fertility: a preliminary prospective study

2018 ◽  
Vol 20 (2) ◽  
pp. 141 ◽  
Author(s):  
Alpaslan Yavuz ◽  
Adem Yokus ◽  
Kerem Taken ◽  
Abdussamet Batur ◽  
Mesut Ozgokce ◽  
...  
Keyword(s):  
Prospective Study ◽  
Shear Wave ◽  
Wave Velocity ◽  
Shear Wave Velocity ◽  
Sperm Count ◽  
Shear Wave Elastography ◽  
Non Invasive ◽  
Sperm Counts ◽  
Wave Technique ◽  
The Mean

Aims: To evaluate the reliability of testicular stiffness quantification using shear wave elastography in predicting the fertility potential of males and for the pre-diagnosis of disorders based upon sperm quantification. Material and methods: One hundred males between the ages of 19-49 years (mean age of 28.77±6.11), ninety of whom with complaints of infertility, were enrolled in this prospective study. Scrotal grey-scale, Doppler ultrasound (US), and mean testicular shear wave velocity quantifications (SWVQs) were performed. The volumes of testes, as well as the grade of varicocele if present, were recorded. The mean shear wave velocity values (SWVVs) of each testis and a mean testicular SWVV for each patient were calculated. The semen-analyses of patients were consecutively performed. Results: There were significant negative correlations between the mean testicular SWVVs of patients and their sperm counts or the testis volumes (r=-0.399, r=-0.565; p<0.01, respectively). A positive correlation was found between testicular volumes and sperm counts (r=0.491, p<0.01). The cut-off values regarding mean testicular SWVV to distinguish normal sperm count from azoospermia and oligozoospermia were 1.465 m/s (75.0% sensitivity and 75.0% specificity) and 1.328 m/s (64.3% sensitivity and 68.2% specificity), respectively, and the value to distinguish oligozoospermia from azoospermia was 1.528 m/s (66.7% sensitivity, 60.7% specificity). Conclusion: The mean testicular SWVQ using the ARFI shear wave technique was a reliable, non-invasive and acceptably stable method for predicting male infertility, especially related to sperm count issues. 

scholarly journals Body Mass Index and Semen Quality in Partners of Infertile Couples

2017 ◽  
Vol 32 (1) ◽  
pp. 14-19
Author(s):  
Tanzeem Sabina Chowdhury ◽  
TA Chowdhury
Keyword(s):  
Negative Correlation ◽  
Semen Quality ◽  
Sperm Count ◽  
Male Partner ◽  
Sperm Concentration ◽  
Fertility Treatment ◽  
Male Partners ◽  
Tertiary Center ◽  
The Mean ◽  
Infertile Couples

Background: Obesity has almost doubled worldwide in the last 50 years and a great portion of these obese population are young adults. It has been proved that increased body weight has a negative correlation with female fertility. Recent studies show there has been decreasing semen quality with concurrent increase in BMI of the male partner. The aim of this study was to investigate the effect of obesity on sperm parameters among the male partners of the infertile couples from an infertility management center in Dhaka, Bangladesh. Methods: A cross sectional study was carried out in Infertility Management Center, a tertiary center for infertility management and IVF in Dhaka, Bangladesh from August to October 2016. A total of 225 men presented for infertility evaluation during this period underwent BMI calculation and semen analysis. Result: Out of 225 male partners, about two third (65.8%) belonged to age 31 to 40 years.Majority (44.4%) of the patients were overweight (25-29.9 kg/m2). The mean total sperm count was found to be 54.4+53.2 million/mL with a range from 0 to 280 million/m. The mean total motility of sperms was found to be 36.8+23.4 percent with a range from 0 to 80 percent. The mean normal morphology was found to be 42.0+22.1 % with a range of 0 to 80 percent. Regression analysis showed no correlation (r=0.003; p=0.966) between BMI and total sperm concentration but showed negative correlation with total motility (r=0.073;p=0.0277) and morphology of sperm (r=0.088; p=0.186). Conclusion: There was a negative correlation between sperm motility and morphology with higher BMI among male partners of couples seeking fertility treatment. So, male partners along with their female counterparts should be counseled about the importance of maintaining an ideal BMI for better fertility outcome. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 14-19

URINARY EXCRETION OF INTERSTITIAL CELL STIMULATING HORMONE AND SPERM CONCENTRATION IN 219 MALES

1969 ◽  
Vol 62 (2) ◽  
pp. 299-305 ◽  
Author(s):  
Leif Wide ◽  
Berndt Kjessler
Keyword(s):  
Urinary Excretion ◽  
Replacement Therapy ◽  
Interstitial Cell ◽  
Sperm Concentration ◽  
Point Of View ◽  
Theoretical Point ◽  
Sperm Counts ◽  
Number Of Patients ◽  
The Mean ◽  
The Individual

ABSTRACT 219 male partners of barren marriages were examined with regard to urinary ICSH (LH) excretion and sperm concentration. The mean ICSH excretion in a group of patients with azoospermia was significantly higher as compared to a group of patients with more than 20 million sperms per ml. The individual excretion values were found to be widely distributed with a considerable overlapping between the groups. Only very few patients with low sperm counts had remarkably low ICSH excretion values. It appears as though only a very limited number of patients with impaired spermatogenesis would benefit from replacement therapy including gonadotrophins with ICSH activity; at least from a theoretical point of view.

HRA Model for Hypercholesterolemia Based on a Longitudinal Health Database

1998 ◽  
Vol 37 (02) ◽  
pp. 130-133
Author(s):  
T. Kishimoto ◽  
Y. Iida ◽  
K. Yoshida ◽  
M. Miyakawa ◽  
H. Sugimori ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Model Analysis ◽  
Serum Total Cholesterol ◽  
Hazards Model ◽  
The Mean ◽  
Health Database ◽  
Observation Period

AbstractTo evaluate the risk factors for hypercholesterolemia, we examined 4,371 subjects (3,207 males and 1,164 females) who received medical checkups more than twice at an AMHTS in Tokyo during the period from 1976 through 1991; and whose serum total cholesterol was under 250 mg/dl. The mean follow-up duration was 6.6 years. A self-registering questionnaire was administered at the time of the health checkup. The endpoint of this study was the onset of hypercholesterolemia when the level of serum total cholesterol was 250 mg/dl and over. We compared two prognosis groups (normal and hypercholesterol) in terms of age, examination findings and lifestyle. After assessing each variable, we employed Cox's proportional hazards model analysis to determine the factors related to the occurrence of hypercholesterolemia. According to proportional hazards model analysis, total cholesterol, triglyceride and smoking at the beginning, and hypertension during the observation period were selected in males; and total cholesterol at the beginning and age were selected in females to determine the factors related to the occurrence of hypercholesterolemia.

Pharmacokinetics and Tolerability of Factor XIII Concentrates Prepared from Human Placenta or Plasma: a Crossover Randomised Study

1995 ◽  
Vol 74 (02) ◽  
pp. 622-625 ◽  
Author(s):  
H H Brackmann ◽  
R Egbring ◽  
A Ferster ◽  
P Fondu ◽  
J M Girardel ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Bleeding Events ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Randomised Study ◽  
The Mean ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study ◽  
Fxiii Activity ◽  
Observation Period

SummaryThe pharmacokinetics and tolerability of factor XIII (FXIII) from plasma were compared with those of FXIII from placenta in a randomised, double-blind, crossover study involving 13 patients with congenital FXIII deficiency. Both FXIII activity and FXIII antigen were monitored. No difference was seen in the mean half-lives of the two preparations (9.3 days and 9.1 days for plasma and placenta FXIII activity, respectively). Response was similar for both preparations, but was slightly greater for FXIII from plasma.Similar results were found for recovery (65% vs 60%). The area under the data completed by extrapolation was significantly higher for FXIII from plasma. No differences between preparations in terms of efficacy or tolerability were observed. It can be concluded that treatment with FXIII concentrate from plasma is as efficient as with FXIII concentrate from placenta in terms of recovery and half-life. Both preparations were equivalent in terms of safety during the observation period. With the administration of monthly injections of approximately 30 U/kg serious bleeding events were prevented and no other serious adverse events occurred.

LACK OF AROMATISATION OF CIRCULATING DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE IN AMENORRHOEIC WOMEN STIMULATED WITH HUMAN GONADOTROPHINS

1965 ◽  
Vol 49 (2) ◽  
pp. 248-261 ◽  
Author(s):  
S. Mancuso ◽  
Francesca P. Mancuso ◽  
K.-G. Tillinger ◽  
E. Diczfalusy
Keyword(s):  
Pregnant Women ◽  
Ovarian Stimulation ◽  
Interstitial Cell ◽  
Follicular Phase ◽  
Radioactive Material ◽  
Dehydroepiandrosterone Sulphate ◽  
Experimental Conditions ◽  
Human Menopausal Gonadotrophin ◽  
Urine Specimens ◽  
Stimulating Hormone

ABSTRACT Two amenorrhoeic women were given a course of 10 injections of human menopausal gonadotrophin (HMG) in daily doses corresponding to 260 IU of follicle stimulating hormone (FSH) activity and 165 IU of interstitial cell stimulating hormone (ICSH) activity. In both patients an extensive ovarian stimulation was observed as indicated by the greatly increased urinary excretion of oestrone, 17β-oestradiol and oestriol. When HMG-treatment was followed subsequently by the administration of human chorionic gonadotrophin (HCG) for 5 days in a total dose of 18 000 and 30 000 IU, respectively, functional corpus luteum tissue was formed in both patients as evidenced by a huge rise in urinary pregnane-3α,20α-diol excretion and by the secretory transformation of a previously atrophic endometrium. At the approximate height of the follicular phase tracer doses of 3H-labelled dehydroepiandrosterone sulphate (DHAS) and 14C-labelled dehydroepiandrosterone (DHA) were administered to both patients in the form of a continuous intravenous infusion of 10 hours' duration. Infusion of the same dose was repeated under identical experimental conditions at the approximate height of the luteal phase. In both patients, very little radioactive material was associated with oestrone and 17β-oestradiol and none with oestriol isolated from 96-hours' urine specimens obtained at both phases of ovarian stimulation. It is concluded that — in contradistinction to the situation in pregnant women — circulating DHAS is not a significant precursor of urinary oestrogens in non-pregnant women.

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