PLASMA GROWTH HORMONE RESPONSE TO VASOPRESSIN:

1970 ◽  
Vol 63 (2) ◽  
pp. 359-377 ◽  
Author(s):  
H.-J. Quabbe
Keyword(s):  
Growth Hormone ◽  
Median Eminence ◽  
Anterior Pituitary ◽  
Immunoreactive Insulin ◽  
List Type ◽  
Plasma Growth Hormone ◽  
Operative Removal ◽  
Provocation Tests ◽  
Males And Females ◽  
Male Subjects

ABSTRACT Plasma growth hormone (HGH) was determined in 12 normal volunteers during intravenous (iv) infusion of synthetic lysine-8-vasopressin (VP). Eight volunteers received only saline infusions but expected all the possible side effects of VP infusion. Significant increases in HGH occurred more often in females than in males during VP infusion. In the females, there was no apparent correlation between the HGH response and stress. Six patients with endocrinologically inactive intrasellar tumours with suprasellar extension and one patient with a suprasellar meningioma were studied with VP and with hypoglycaemia tests. None of the patients responded to VP infusion with an increase in HGH. Only the meningioma patient responded to hypoglycaemia. One patient did not respond to hypoglycaemia before, but responded after operative removal of the suprasellar part of the tumour. Responses of urinary 17-OHCS in metyrapone tests and of plasma cortisol during VP infusion were positive in several of the patients, demonstrating preservation of blood flow from the stalk median eminence to the anterior pituitary gland and the presence of functional anterior pituitary tissue. The blood sugar increased and immunoreactive insulin levels remained low in all subjects during VP tests. It is concluded, that iv VP offers no reliable test for HGH release at least in male subjects. Stress is not the only determinant of HGH release during iv infusion of VP in females. In males and females VP cannot differentiate pituitary from hypothalamic causes of diminished HGH release. In some cases of pituitary tumours, pressure of the tumour on the median eminence of the hypothalamus may be the cause of the impaired HGH release in response to provocation tests.

DIFFERENT EFFECTS OF EXOGENOUS CYCLIC ADENOSINE MONOPHOSPHATE AND ITS DIBUTYRYL DERIVATIVE ON PLASMA GROWTH HORMONE, GLUCOSE, INSULIN AND CORTISOL

1976 ◽  
Vol 83 (1) ◽  
pp. 15-25
Author(s):  
M. Vanderschueren-Lodeweyckx ◽  
W. Proesmans ◽  
E. Eggermont ◽  
R. Eeckels
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Normal Subjects ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Hormone Levels ◽  
The Mean

ABSTRACT The effects of the infusion in four different dosages (0.001, 0.005, 0.02 and 0.2 mg/kg/min during 60 min) of cyclic 3′,5′-adenosine monophosphate and of its dibutyryl derivative on plasma growth hormone and on glucose, immunoreactive insulin and cortisol were studied in 38 normal subjects and in 10 patients with idiopathic hypopituitarism. In normal subjects cyclic 3′,5′-adenosine monophosphate provokes an increase in plasma growth hormone levels (only when a dosage of 0.2 mg/kg/min is used) without any changes in plasma glucose, insulin and cortisol. The maximal value of the means is observed 75 min after starting the infusion. Dibutyryl cyclic 3′,5′-adenosine monophosphate (0.2 and 0.02 mg/kg/min) provokes a dose-related rise in plasma growth hormone levels which is always preceded by hyperglycaemia and hyperinsulinaemia. The peak of the mean growth hormone levels occurs at 135 min after initiation of the infusion. In all but one hypopituitary patients the nucleotides do not promote growth hormone secretion. It is concluded that exogenous cyclic 3′,5′-adenosine monophosphate and its dibutyryl derivative may not be considered as analogous and that both compounds may contribute to study growth hormone release in normal subjects and in patients with growth abnormalities.

GROWTH HORMONE RELATED TO INSULIN AND SUGAR IN NOCTURNAL BLOOD PLASMA OF LACTATING COWS

1976 ◽  
Vol 82 (4) ◽  
pp. 767-773 ◽  
Author(s):  
K. Halse ◽  
Anne Kristine Blom ◽  
K. Hove
Keyword(s):  
Growth Hormone ◽  
Blood Plasma ◽  
Immunoreactive Insulin ◽  
Plasma Samples ◽  
Plasma Growth Hormone ◽  
Lactating Cows ◽  
High Insulin ◽  
Plasma Immunoreactive Insulin ◽  
Correlation Tests ◽  
Lactation Cycle

ABSTRACT Nocturnal blood plasma samples from about 190 indoor-fed cows at varying stages of the lactation cycle showed wide variations in the concentrations of sugar (43–88 mg/100 ml) and acetoacetate (0.12–8.7 mg/100 ml). Plasma immunoreactive insulin decreased and acetoacetate increased with decreasing sugar. Plasma growth hormone (GH) was significantly correlated to insulin (r = −0.24, P < 0.001) and to sugar (r = −0.15, P < 0.05), but not to acetoacetate (r = +0.13). Since the plasma level of GH in bovines is known to vary widely from hour to hour, individual cows are poorly represented by single determinations of the hormone. However, in accordance with the results from the correlation tests, different GH averages, about 11 and 9 ng/ml, were found for groups of animals with plasma sugar respectively below and above 70 mg/100 ml. By subgrouping according to insulin levels within sugar ranges, categories could be singled out with GH averages as different as 12.7 ng/ml (low sugar - low insulin) and 8.3 ng/ml (high sugar - high insulin). The findings are consistent with the view that GH is involved in the regulation of energy metabolism in bovines. But no support has been provided for the hypothesis of GH hypersecretion as a cause of ketosis in cows.

CHANGES IN PLASMA GROWTH HORMONE AND INSULIN OF THE HUMAN FOETUS FOLLOWING HYSTEROTOMY

1971 ◽  
Vol 66 (4) ◽  
pp. 577-586 ◽  
Author(s):  
R. C. Turner ◽  
B. Schneeloch ◽  
P. Paterson
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Plasma Insulin Concentration ◽  
Plasma Immunoreactive Insulin ◽  
The Mean ◽  
Serial Samples

ABSTRACT Plasma immunoreactive insulin and growth hormone of 20–24 weeks' gestation human foetuses were assayed in serial samples following delivery by hysterotomy. The mean umbilical cord plasma growth hormone concentration was 71 ng/ml (range 13–120 ng/ml) and the mean plasma insulin was 5 μU/ml (range 2–8 μU/ml). Following delivery the growth hormone levels increased, but there was no significant change in plasma insulin concentration. The hypothalamic-hypophyseal axis controlling growth hormone secretion appears to be developed by 20 weeks' gestation, and »stress« appears to be a provocative stimulus.

Changes of molecular forms of growth hormone in bromocriptine treated acromegaly in relation to changes of somatomedin-C and clinical response

1985 ◽  
Vol 108 (2) ◽  
pp. 145-150 ◽  
Author(s):  
J. W. R. Nortier ◽  
R. J. M. Croughs ◽  
G. H. Donker ◽  
J. H. H. thijssen ◽  
F. Schwarz
Keyword(s):  
Growth Hormone ◽  
Clinical Response ◽  
Molecular Forms ◽  
List Type ◽  
Plasma Growth Hormone ◽  
Somatomedin C ◽  
The Mean ◽  
Active Acromegaly ◽  
Improvement Score

Abstract. Eleven patients with active acromegaly were treated with 10–20 mg bromocriptine daily for a period of 6–9 months. The clinical response was evaluated by a 'clinical and metabolic improvement score'. The biochemical response was evaluated by measurement of both the mean plasma growth hormone (GH) level during the day and the somatomedin-C (Sm-C) concentration. Before and at the end of the treatment period plasma samples were fractionated by Sephadex G-100 chromatography in order to study the effects of chronic bromocriptine treatment on the concentrations of total GH and its different molecular forms. The main observations may be summarized as follows: Three immunoreactive components were observed on Sephadex chromatography corresponding to molecular weight above 100 000 (big-big GH), 40000–60000 (big GH) and 20000–22000 (little GH). Bromocriptine treatment induced preferentially a reduction of little GH. There was a very good correlation between the decrease of little GH and total GH, and both were significantly correlated with the clinical response. The correlation between the decrease of Sm-C values and that of little and total GH as well as between the decrease of Sm-C and the clinical response was poor. It is concluded that a) measurement of little GH is not superior to the determination of total GH in the assessment of disease activity of bromocriptine treated acromegalic patients; b) both methods are superior to the measurement of plasma Sm-C levels; c) clinical response out of proportion ot the fall of total GH which can be explained by a preferential reduction of little GH, has not been observed in our investigations.

Effect of Dopamine on Plasma Growth Hormone and Prolactin Concentrations under Anaesthesia

1988 ◽  
Vol 16 (6) ◽  
pp. 403-412 ◽  
Author(s):  
K. Mikawa ◽  
M. Kusunoki ◽  
H. Obara ◽  
S. Iwai
Keyword(s):  
Growth Hormone ◽  
General Anaesthesia ◽  
Dopamine Receptors ◽  
Anterior Pituitary ◽  
Plasma Prolactin ◽  
Plasma Growth Hormone ◽  
Prolactin Response

Five patients with acromegaly and five patients with prolactinoma undergoing general anaesthesia were studied. Concentrations of plasma growth hormone in patients with acromegaly and concentrations of plasma prolactin in patients with prolactinoma were measured before anaesthesia, when 250 mg levodopa was administered orally, and after anaesthesia when dopamine was infused intravenously at a rate of 5 μg/kg-min. There was no difference in hormonal (growth hormone or prolactin) response to either treatment in the anaesthetized and the awake states. These findings indicate that the functioning of dopamine receptors in the anterior pituitary is not affected by anaesthesia.

THE EXTRACTION OF PROLACTIN FROM HUMAN PITUITARY GLANDS

1965 ◽  
Vol 49 (1) ◽  
pp. 1-16 ◽  
Author(s):  
M. Apostolakis
Keyword(s):  
Growth Hormone ◽  
Pituitary Gland ◽  
List Type ◽  
Distilled Water ◽  
Hormone Activity ◽  
Isoelectric Precipitation ◽  
Human Pituitary ◽  
Pituitary Glands ◽  
Prolactin Content ◽  
The Mean

ABSTRACT A method for the extraction of prolactin from human pituitary glands is described. It is based on acetone drying, distilled water extraction, acetone and isoelectric precipitation. Two main products are obtained: Fraction R8 with a mean prolactin activity of 12.2 IU/mg and fraction U8 with a mean prolactin activity of 8.6 IU/mg. The former fraction does not contain any significant gonadotrophin activity and the latter contains on an average 50 HMG U/mg. In both cases contamination with ACTH and MSH is minimal. The growth hormone activity of both these fractions is low. It is postulated that in man too, prolactin and growth hormone are two distinct hormones. A total of 1250 human pituitary glands have been processed by this method. The mean prolactin content per pituitary gland has been found to be 73 IU.

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