ARTIFICIAL STIMULATORY AND HORMONAL REQUIREMENTS OF DECIDUAL ALKALINE PHOSPHATASE IN THE PSEUDOPREGNANT RAT

1969 ◽  
Vol 61 (1) ◽  
pp. 164-172 ◽  
Author(s):  
J. P. Manning ◽  
S. G. Carter ◽  
M. C. Butler
Keyword(s):  
Alkaline Phosphatase ◽  
Enzyme Activity ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Similar Response ◽  
Fallopian Tubes ◽  
Pregnant Rats ◽  
Implantation Sites ◽  
Alkaline Phosphatase Reaction

ABSTRACT The influences of uterine traumatization, ovariectomy and hormone replacement therapy on decidual alkaline phosphatase were studied in pseudopregnant rats. The enzyme was also assayed in implantation sites of pregnant rats with unilateral section and ligation of the Fallopian tubes. In all pseudopregnant animals with traumatized uteri, intact or castrate receiving progesterone replacement, the enzyme activity was 12 times more active on day 8 of pseudopregnancy than the contralateral non-traumatized horn. The alkaline phosphatase reaction of day 8 pregnant rats demonstrated a similar response at the implantation site. No increased enzyme was elicited by pseudopregnant rats treated with 17β-oestradiol and/or progesterone or animals ovariectomized and traumatized on day 4 and given only oestrogen. Additionally, the changes in alkaline phosphatase from day 5 to 10 in the intact and hormone-treated, ovariectomized pseudopregnant rats with traumatized uteri were similar to those demonstrated by the intact pregnant animals, i. e., an increased reaction from day 5 to 8 and decreased activity from day 8 to 10. The data support the view that the rise in decidual alkaline phosphatase in pregnant or traumatized pseudopregnant animals is dependent on the combined effect of uterine irritation and a progesterone-conditioned endometrium.

Markers of bone remodeling in patients with surgical menopause undergoing hormone replacement therapy with Divigel

2021 ◽  
Vol 50 (3) ◽  
pp. 70-75
Author(s):  
S. V. Yureneva ◽  
V. P. Smetnik ◽  
N. V. Lyubimova ◽  
V. M. Abaev
Keyword(s):  
Alkaline Phosphatase ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Hormone Replacement ◽  
Hormonal Replacement Therapy ◽  
Mineral Density ◽  
Hormonal Replacement ◽  
Surgical Menopause

Twenty women with surgical menopause, 40-50 years of age, received hormonal replacement therapy with transdermic preparation Divigel during 24 months. On the background of therapy with Divigel we witnessed normalization of indeces of osteal remodelingconsiderable decrease pyridinoline and deoxypyridinoline, and elevation of alkaline phosphatase. Mineral density of bone tissue in the group of patients with surgical menopause waslowerin comparison with control (p0,01). Divigeltumedto exertprotective influence on the bone tissue inpatients with osteoporosis irrespective о f duration о f surgical menopause by the beginning of therapy.

scholarly journals The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes

2014 ◽  
Vol 27 (2) ◽  
pp. 92-96 ◽  
Author(s):  
Mansur Rahnama ◽  
Michal Lobacz ◽  
Anna Szyszkowska ◽  
Grzegorz Trybek ◽  
Maryla Kozicka-Czupkallo
Keyword(s):  
Alkaline Phosphatase ◽  
Hormone Replacement Therapy ◽  
Bone Formation ◽  
Replacement Therapy ◽  
Peripheral Blood ◽  
Bone Mineralization ◽  
Hormone Replacement ◽  
Peripheral Blood Lymphocytes ◽  
Mucosal Epithelium ◽  
Osteoblast Activity

Abstract In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.

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