EFFECT OF THE EXPERIMENTAL DECIDUOMA ON STEROID HYPERTENSION IN THE RAT

1968 ◽  
Vol 58 (2) ◽  
pp. 177-182
Author(s):  
H. C. Moore ◽  
F. P. Biliczki
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Equivalent Time ◽  
Metrial Gland ◽  
Decidual Reaction

ABSTRACT Experimental deciduomas which are maintained for 5 to 6 days do not lower the blood pressure in steroid hypertensive rats. In animals maintained longer only the metrial gland of the deciduoma survives but this too does not have a hypotensive action. It is concluded that the maternal decidual reaction in pregnant hypertensive rats is not responsible for the fall of blood pressure when this occurs at an equivalent time of gestation of up to 10 or 11 days and that the metrial gland is not responsible for the fall of blood pressure at whatever time the fall occurs during gestation.

THE FALL OF BLOOD PRESSURE FOLLOWING INDUCTION OF DECIDUOMATA IN STEROID HYPERTENSIVE RATS RECEIVING PROGESTERONE

1968 ◽  
Vol 59 (2) ◽  
pp. 227-234 ◽  
Author(s):  
H. C. Moore ◽  
I. Cserhati ◽  
F. P. Biliczki
Keyword(s):  
Blood Pressure ◽  
Hypotensive Effect ◽  
Hypertensive Rats ◽  
Pregnant Rats ◽  
Hypertensive Rat ◽  
Equivalent Time ◽  
Metrial Gland ◽  
Blood Pressure Responses ◽  
A Minor ◽  
Maternal Decidua

ABSTRACT Experimental deciduomata and progesterone together lower the blood pressure in the steroid hypertensive rat from the 5th to 10th day of decidual growth i. e. from the 10th to 15th day of pseudopregnancy. This would suggest that the fall of blood pressure at an equivalent time of gestation in hypertensive pregnant rats could be due to the maternal decidua under the influence of progesterone. It is further considered that the metrial gland of the deciduoma is more likely to be responsible for the hypotensive effect and by comparison that the metrial gland is implicated in the hypotensive effect of pregnancy. Progesterone alone also exerts a minor hypotensive effect in those animals in which a nephrectomy forms part of the hypertension regimen and indicates one way in which a maternal renal factor could influence blood pressure responses in hypertensive pregnant rats.

Influence of the sympathetic nervous system and vasopressin on the blood pressure lowering effect of nifedipine in deoxycorticosterone acetate–salt hypertensive rats

1987 ◽  
Vol 73 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Yutaka Takata ◽  
Yoshiaki Yamashita ◽  
Shuichi Takishita ◽  
Masatoshi Fujishima
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Calcium Influx ◽  
Hypotensive Effect ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Blood Pressure Lowering Effect ◽  
Hypotensive Action ◽  
Sympathetic Nervous

1. The role of the sympathetic nervous system and the effect of vasopressin (AVP) on the hypotensive action of nifedipine (Nf) were evaluated in conscious, unrestrained normotensive and DOCA–salt hypertensive rats. 2. The hypotensive response to Nf was much greater in DOCA rats than in the controls. 3. Solitary blockade of the sympathetic nervous system or AVP, did not alter the Nf effect in either DOCA or control rats. However, a combination clearly diminished the effect of Nf in the DOCA group, but enhanced it in the controls. The inhibition of angiotensin II (ANG II) augmented the hypotensive effect of Nf in control animals, but not in the DOCA rats. The percentage fall in blood pressure with Nf was much the same in both groups after the combined inhibition of the sympathetic nervous system and AVP. 4. The enhanced hypotensive action of Nf in DOCA rats may be dependent on the hyperactivity of the sympathetic nervous system and AVP, which facilitates calcium influx, and in the normotensive animals the depressor response to Nf may relate to blockade of the calcium influx, independent of the sympathetic nervous system, AVP and ANG II.

scholarly journals Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Agnieszka Walkowska ◽  
Luděk Červenka ◽  
John D. Imig ◽  
John R. Falck ◽  
Janusz Sadowski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Function ◽  
Spontaneously Hypertensive Rats ◽  
Therapeutic Potential ◽  
Receptor Blocker ◽  
Epoxyeicosatrienoic Acid ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Spontaneously Hypertensive ◽  
Arterial Blood

Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function. EETs deficiency and increased renal formation of 20-HETE contribute to hypertension in spontaneously hypertensive rats (SHR). We explored the effects of 14,15-EET analog (EET-A) and of 20-HETE receptor blocker (AAA) on BP and kidney function in this model. In anesthetized SHR the responses were determined of mean arterial blood pressure (MABP), total renal (RBF), and cortical (CBF) and inner-medullary blood flows, glomerular filtration rate and renal excretion, to EET-A, 5 mg/kg, infused i.v. for 1 h to rats untreated or after blockade of endogenous EETs degradation with an inhibitor (c-AUCB) of soluble epoxide hydrolase. Also examined were the responses to AAA (10 mg/kg/h), given alone or together with EET-A. EET-A significantly increased RBF and CBF (+30% and 26%, respectively), seen already within first 30 min of infusion. The greatest increases in RBF and CBF (by about 40%) were seen after AAA, similar when given alone or combined with EET-A. MABP decreased after EET-A or AAA but not significantly after the combination thereof. In all groups, RBF, and CBF increases preceded the decrease in MABP. We found that in SHR both EET-A and AAA induced renal vasodilation but, unexpectedly, no additive effect was seen. We suggest that both agents have a definite therapeutic potential and deserve further experimental and clinical testing aimed at introduction of novel antihypertensive therapy.

The Central Hypotensive Action of Clonidine and BAY 1470 in Cats and Rats

1974 ◽  
Vol 48 (s2) ◽  
pp. 273s-276s ◽  
Author(s):  
L. Finch
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Responses ◽  
Intraventricular Administration ◽  
Dopaminergic Receptors ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Cardiovascular Actions ◽  
Small Doses ◽  
6 Hydroxydopamine ◽  
Stimulation Of

1. Intraventricular clonidine and BAY 1470, administered in small doses to conscious renal hypertensive cats, produced a fall in mean blood pressure lasting for a period of 3 h. This fall in blood pressure was accompanied by a marked bradycardia. 2. Pretreatment with intraventricular phentolamine (0.3–6 μmol), piperoxan (0.18–0.74 μmol) or tolazoline (0.35–1 μmol) abolished the hypotensive effects of intraventricular clonidine (74 nmol), whereas pretreatment with haloperidol (2.6 μmol/kg, intraperitoneally), or desmethylimipramine (3.3 μmol/kg, intraperitoneally, or 1.7 μmol, intraventricularly) did not modify the cardiovascular responses to clonidine. 3. Emesis was observed 1 min after intraventricular administration of clonidine (18–112 nmol) or BAY 1470 (0.07–0.14 μmol), which always preceded the cardiovascular actions and was still observed after pretreatment with haloperidol, desmethylimipramine, phentolamine, piperoxan or tolazoline. 4. In conscious hypertensive rats clonidine (0.6 μmol/kg, intraperitoneally) produced a marked fall in blood pressure that was antagonized by centrally acting α-adrenoreceptor blocking agents but not modified by pretreatment with either 6-hydroxydopamine (three doses of 1 μmol, intraventricularly) or 5,6-dihydroxytryptamine (0.1 μmol). 5. It is concluded that the anti-hypertensive responses to clonidine are mediated via stimulation of central α-adrenoreceptors and are independent of central dopaminergic receptors, intact central serotonergic neurons and intact adrenergic uptake mechanisms.

THE DURATION OF THE FALL OF BLOOD PRESSURE FOLLOWING THE INDUCTION OF DECIDUOMATA AND THE ADMINISTRATION OF PROGESTERONE IN STEROID HYPERTENSIVE RATS

1970 ◽  
Vol 63 (2) ◽  
pp. 242-252 ◽  
Author(s):  
H. C. Moore ◽  
I. Cserhat ◽  
K. Wilson
Keyword(s):  
Blood Pressure ◽  
Hypotensive Effect ◽  
Related Phenomenon ◽  
Hypertensive Rats ◽  
Unknown Mechanism ◽  
Gland Cells ◽  
Hypotensive Episode ◽  
Metrial Gland ◽  
Main Effects

ABSTRACT Experimental deciduomata produce a protracted fall of blood pressure in steroid hypertensive rats. The fall begins at between 9 and 13 days of pseudopregnancy, lasts for between 8 and 14 days and is then followed by a restoration to higher levels between 17 and 24 days. The metrial gland of the deciduomata is thought to be responsible for the fall. Parenteral progesterone has two main effects. It enhances the degree of the fall of blood pressure and also prolongs the survival of deciduomata to beyond 22 days of pseudopregnancy. Progesterone does not alter the time of onset nor the duration of the hypotensive episode and the return of the blood pressure to higher levels takes place even though the metrial gland of the deciduomata is still viable and progesterone still being administered. It is considered that the duration of the hypotensive episode is determined either by a changed function of the metrial gland cells with duration or to an entirely different but unknown mechanism. The present findings suggest that the hypotensive effect of pregnancy in hypertensive rats is a related phenomenon and is due in part to the function of metrial gland cells of the pregnancy decidua under the influence of progesterone.

THE EFFECT OF FOETAL REMOVAL ON THE BLOOD PRESSURE IN STEROID HYPERTENSIVE RATS

1971 ◽  
Vol 67 (3) ◽  
pp. 590-596 ◽  
Author(s):  
H. C. Moore ◽  
J. Borvendeg ◽  
K. Wilson
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Hypotensive Effect ◽  
The Other ◽  
Hypertensive Rats ◽  
Pregnancy Hypertension ◽  
Human Pregnancy ◽  
Other Hand ◽  
Metrial Gland

ABSTRACT In unilaterally nephrectomized hypertensive rats receiving DOCA, cortisone and saline the blood pressure falls after the removal of the foetuses as though the animals continued to be pregnant with the foetuses in situ. On the other hand, when the foetuses are removed from steroid hypertensive animals in which the maternal kidneys remain intact the blood pressure remains at hypertensive levels. The metrial gland part of the placenta appears histologically viable after foetal removal. We conclude from the present and earlier experiments that the usual hypotensive effect of pregnancy in hypertensive animals is due to a vasodepressor agent produced by the foetuses and the metrial gland moiety of the placenta and that the activity of this agent is subject to maternal renal function. A relation between these experiments and human pregnancy hypertension is not clear but we suggest that in human pregnancy, hypertension could be due either to failure of the foetoplacental vasodepressor or vasodilator agent or to destruction or excretion of this agent by the maternal kidney.

ANG-(3–4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA

2014 ◽  
Vol 306 (8) ◽  
pp. F855-F863 ◽  
Author(s):  
Juliana Dias ◽  
Fernanda M. Ferrão ◽  
Flavia Axelband ◽  
Adriana K. Carmona ◽  
Lucienne S. Lara ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Arterial Pressure ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Hypotensive Action ◽  
Proximal Tubule Cells ◽  
Spontaneously Hypertensive ◽  
Wky Rats ◽  
Nephron Segment ◽  
Wistar Kyoto

The physiological roles of ANG-(3–4) (Val-Tyr), a potent ANG II-derived peptide, remain largely unknown. The present study 1)investigates whether ANG-(3–4) modulates ouabain-resistant Na+-ATPase resident in proximal tubule cells and 2) verifies whether its possible action on pumping activity, considered the fine tuner of Na+reabsorption in this nephron segment, depends on blood pressure. ANG-(3–4) inhibited Na+-ATPase activity in membranes of spontaneously hypertensive rats (SHR) at nanomolar concentrations, with no effect in Wistar-Kyoto (WKY) rats or on Na+-K+-ATPase. PD123319 (10−7M) and PKA(5–24)(10−6M), an AT2receptor (AT2R) antagonist and a specific PKA inhibitor, respectively, abrogated this inhibition, indicating that AT2R and PKA are central in this pathway. Despite the lack of effect of ANG-(3–4) when assayed alone in WKY rats, the peptide (10−8M) completely blocked stimulation of Na+-ATPase induced by 10−10M ANG II in normotensive rats through a mechanism that also involves AT2R and PKA. Tubular membranes from WKY rats had higher levels of AT2R/AT1R heterodimers, which remain associated in 10−10M ANG II and dissociate to a very low dimerization state upon addition of 10−8M ANG-(3–4). This lower level of heterodimers was that found in SHR, and heterodimers did not dissociate when the same concentration of ANG-(3–4) was present. Oral administration of ANG-(3–4) (50 mg/kg body mass) increased urinary Na+concentration and urinary Na+excretion with a simultaneous decrease in systolic arterial pressure in SHR, but not in WKY rats. Thus the influence of ANG-(3–4) on Na+transport and its hypotensive action depend on receptor association and on blood pressure.

PENGARUH PEMBERIAN BELIMBING DAN MENTIMUN TERHADAP PENDERITA HIPERTENSI DI DESA LAU KERSIK KECAMATAN GUNUNG SITEMBER KABUPATEN DAIRI

2019 ◽  
Vol 2 (1) ◽  
pp. 18-23
Author(s):  
Herri Novita Br Tarigan ◽  
Prista Hotmarina Purba
Keyword(s):  
Blood Pressure ◽  
Data Analysis ◽  
Fruit Juice ◽  
Blood Pressure Reduction ◽  
Reduce Blood Pressure ◽  
Pharmacological Therapy ◽  
Hypertensive Patients ◽  
Star Fruit ◽  
Equivalent Time ◽  
Life Threatening

Hypertension is a disease that is not uncommon in the community, including the Bukit Lau Kersik village. People with hypertension often do not show long-term symptoms and can be life-threatening. However, one of the management of hypertension that can be used as non-pharmacological therapy is consuming starfruit juice and cucumber which is quite easy to find in the Bukit Lau Kersik village. This combination of juices contains potassium which can reduce blood pressure in patients with hypertension. This study used Equivalent Time Sample Design with 14 subjects with hypertension in the Bukit Lau Kersik Village, Gunung Sitember Subdistrict, Dairi District. The technique of this research sample used Non-Probability Sampling with Saturated Sampling. The instrument used was a sphygmomanometer and a stethoscope. Bivariate data analysis in this study was the Wilcoxon statistical test. Based on the data analysis performed, the value of p = 0.011 (p= < 0.05) was obtained, meaning that there was a significant relationship between giving star fruit juice and cucumber to hypertensive patients. Then it can be concluded that there is an influence between giving star fruit and cucumber juice to blood pressure reduction in hypertensive patients in Bukit Lau Kersik Village Gunung Sitember Subdistrict, Dairi District in 2019. Suggestion: The factors that affect blood pressure in hypertensive patients and checking blood pressure before drinking star fruit juice and cucumber.

THE EFFECTS OF ACUPUNCTURE ON CARDIAC MUSCLE CELLS AND BLOOD PRESSURE IN SPONTANEOUS HYPERTENSIVE RATS

2004 ◽  
Vol 29 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Hung-Chien Wu ◽  
Jaung-Geng Lin ◽  
Chun-Hsien Chu ◽  
Yung-Hsien Chang ◽  
Chung-Gwo Chang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Muscle ◽  
Muscle Cells ◽  
Hypertensive Rats ◽  
Cardiac Muscle Cells
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