OBSERVATIONS ON THE RELATIONSHIP BETWEEN THE MAXIMAL THYROXINE BINDING CAPACITIES OF THYROXINE-BINDING INTERALPHA GLOBULIN AND THYROXINE-BINDING PREALBUMIN, THE SERUM PROTEIN BOUND IODINE CONCENTRATION AND SEXUAL MATURITY IN ADOLESCENTS

1967 ◽  
Vol 54 (3) ◽  
pp. 494-504 ◽  
Author(s):  
R. E. Goldsmith ◽  
J. L. Rauh ◽  
R. Kloth ◽  
J. Dahlgren

ABSTRACT The serum PBI concentration and the maximal thyroxine binding capacity for TBG and TBPA were determined in 100 adolescents. The subjects were classified according to sex and degree of sexual maturity. PBI was determined by an autoanalyzer method: Maximal thyroxine binding capacity for TBG fell with increasing maturation in males while TBPA capacity rose in both sexes. The slight changes in serum PBI noted with increasing sexual maturity correlated directly with the slight changes in TBG binding capacity; no correlation between PBI and TBPA binding capacity was observed as maturity progressed.

1953 ◽  
Vol 12 (1) ◽  
pp. 3-9 ◽  
Author(s):  
H. O. Kunkel ◽  
R. W. Colby ◽  
Carl M. Lyman

1967 ◽  
Vol 24 (11) ◽  
pp. 2339-2354 ◽  
Author(s):  
James E. Stewart ◽  
John W. Cornick ◽  
Diane M. Foley ◽  
M. F. Li ◽  
C. M. Bishop

Total serum protein values, hemocyte numbers, and muscle weights were determined for 216 intermolt lobsters immediately after their capture, and for 230 others held captive under a variety of dietary and environmental conditions. Average muscle values ranged from approximately 13% to the more normal 20–25% of the live animals' weight, depending upon experimental conditions. The total serum protein up to a level of 55 mg/ml was shown to be a reliable indicator of muscle weights, although the relationship was not identical for all lobster groups. It appeared to be modified chiefly by the areas from which the different groups were taken. Diet was more important than the temperatures (5 to 14 C) in affecting changes in muscle and serum protein values. Starvation caused a greater reduction (50 to 70%) in the size of the hepatopancreas than in the muscle. Histological examination of the hepatopancreatic tissue showed that the lipid content was markedly reduced upon starvation and that a degeneration of this organ was apparent for lobsters fed a beef liver and herring diet. Measurement of serum proteins would appear to be a useful technique in experiments on lobster nutrition and have value, within specified limits, for assessing the physiological condition of wild lobsters.


PEDIATRICS ◽  
1962 ◽  
Vol 30 (1) ◽  
pp. 27-31
Author(s):  
Ralph H. Kunstadter ◽  
Harvey Buchman ◽  
Morad Jacobson ◽  
Leo Oliner

The in vitro erythrocyte uptake studies of radioactive 1-triiodothyronine in 70 normal children, ranging in age from newborn infants to 13 years, are presented. The data reveal elevated uptake values in these children as compared to adults, indicating alteration in binding capacity of thyroxin-binding serum protein carriers, in all probability a reduction in thyroxin-binding prealbumin capacity.


2018 ◽  
Vol 63 (4) ◽  
pp. 444-454
Author(s):  
Jay Ezrielev

This article examines how capacity constraints affect horizontal mergers. Binding capacity constraints for merging firms may mitigate merger price effects, but capacity constraints for nonmerging firms may either amplify or mitigate such effects. The presence of capacity constraints for both the merging and nonmerging firms in a market further complicates the analysis of merger price effects. Capacity constraints may also confound the relationship between market concentration and merger price effects. In addition, capacity constraints affect market definition analysis and analytical tools such as merger simulation and upward pricing pressure indexes. Analyzing the effects of capacity constraints on mergers continues to be a challenge for merger reviews.


2014 ◽  
Vol 26 (3) ◽  
pp. 221-230 ◽  
Author(s):  
Katrina D. DuBose ◽  
Andrew J. McKune

The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.


2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Amtyaz Safi

A study was conducted on the histological structure, morphology of gonads and spermatogenesis of testes of the striped piggy fish, Pomadasys stridens from Karachi coast of Pakistan. The reproductive biology of grunt fishes, and the Pomadasys stridens in particular, is not well understood with respect to functional morphology and histology of the gonads in relation to sexual maturity. In the course of an investigation of the genetic variability of Pomadasys stridens, differences in morphology were observed between the right and left gonad of male and female fish and the size of the fat body associated with the gonads. Histological examinations were made to determine the relationship between these morphological differences and the reproductive state of the gonads. Findings made from this paper are gonad morphology, histology, and spermatogenesis and relate them to the reproductive biology of this species.


eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Erin A Clark ◽  
Michael Rutlin ◽  
Lucia Capano ◽  
Samuel Aviles ◽  
Jordan R Saadon ◽  
...  

Retinoic acid-related orphan receptor beta (RORβ) is a transcription factor (TF) and marker of layer 4 (L4) neurons, which are distinctive both in transcriptional identity and the ability to form aggregates such as barrels in rodent somatosensory cortex. However, the relationship between transcriptional identity and L4 cytoarchitecture is largely unknown. We find RORβ is required in the cortex for L4 aggregation into barrels and thalamocortical afferent (TCA) segregation. Interestingly, barrel organization also degrades with age in wildtype mice. Loss of RORβ delays excitatory input and disrupts gene expression and chromatin accessibility, with down-regulation of L4 and up-regulation of L5 genes, suggesting a disruption in cellular specification. Expression and binding site accessibility change for many other TFs, including closure of neurodevelopmental TF binding sites and increased expression and binding capacity of activity-regulated TFs. Lastly, a putative target of RORβ, Thsd7a, is down-regulated without RORβ, and Thsd7a knock-out alone disrupts TCA organization in adult barrels.


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