THE ADRENAL REPONSE OF HAMSTERS, GERBILS AND RATS TO EXOGENOUS CORTICOTROPHIN OR UNILATERAL ADRENALECTOMY
ABSTRACT Either unilateral or sham adrenalectomy caused a marked decrease in the ascorbic acid content of the remaining adrenal gland of the rat. An even greater drop of this constituent was obtained one hour after the administration of 10 IU of corticotrophin. Rat adrenal cholesterol was somewhat less responsive to the above treatment. Unilateral or sham adrenalectomy had no significant effect on adrenal ascorbic acid or cholesterol in the hamster. Twenty IU of corticotrophin caused a 20% drop in hamster adrenal cholesterol whereas 10 IU did not. The response of the Mongolian gerbil to corticotrophin or adrenalectomy, either unilateral or sham, was approximately the same as that of the rat.