EVIDENCE FOR A CALCITONIN EFFECT IN MAN.

1965 ◽  
Vol 48 (1) ◽  
pp. 132-136 ◽  
Author(s):  
Heinrich G. Haas ◽  
Heinz Affolter ◽  
Ulrich C. Dubach
Keyword(s):  
Calcium Level ◽  
Plasma Calcium ◽  
Parathyroid Glands ◽  
List Type ◽  
Parathyroid Extract ◽  
Plasma Magnesium ◽  
Subsequent Rise

ABSTRACT In 1962 Copp et al. (1962) demonstrated a second, plasma calcium lowering factor from the parathyroid glands called calcitonin. These findings were subsequently confirmed by Kumar et al. (1963). Up to the present, however, calcitonin has not been demonstrated in man. In a patient with hypocalcaemic tetany the injection of a commercial parathyroid extract caused the same changes in plasma calcium as described by Copp et al. (1962) in dogs, i. e. an initial fall and a subsequent rise in the calcium level. In addition, changes in plasma magnesium paralleling those of calcium were also observed.

THE EFFECTS OF CALCITONIN AND PARATHORMONE ON PLASMA MAGNESIUM LEVELS BEFORE AND AFTER BIRTH IN THE RAT

1974 ◽  
Vol 61 (1) ◽  
pp. 1-13 ◽  
Author(s):  
J. M. GAREL ◽  
J. P. BARLET
Keyword(s):  
Parathyroid Hormone ◽  
Salmon Calcitonin ◽  
Magnesium Level ◽  
Plasma Calcium ◽  
Parathyroid Glands ◽  
Small Decrease ◽  
Newborn Rats ◽  
Newborn Rat ◽  
Before And After ◽  
Plasma Magnesium

SUMMARY Plasma magnesium levels measured in rats from 16·5 to 21·5 days of gestation and during the first week after birth proved to be invariably higher in the foetus than in the mother. The highest level observed was in the 16·5-day-old foetus. A small decrease occurred between 16·5 and 17·5 days of gestation; thereafter the plasma magnesium level did not change until 19·5 days and then decreased between 19·5 and 21·5 days. After birth an increase in plasma magnesium occurred with suckling but then remained constant during the first week of life. Parathyroid hormone (0·25 USP unit/g) injected into 21·5-day-old foetuses had no effect on plasma magnesium levels from 0·5 to 24 h after injection. This dose was found to be very potent in raising plasma calcium values 4 h after injection. In the 3-day-old newborn rat this dose was similarly ineffective. Removal of the foetal parathyroid glands by decapitation at 17·5 days of gestation was followed by a decrease in plasma magnesium at 21·5 days of gestation. Parathyroid hormone (0·25 USP unit/g) injected into decapitated foetuses did not change the level of magnesium in the plasma. Salmon calcitonin (S-CT) at two doses (0·4 and 4 ng/g) produced no effect on plasma magnesium concentrations in 3-day-old newborn rats 3 h after injection; whereas at both doses, marked diminutions in plasma calcium and phosphate concentrations were observed. After injection of 40 ng S-CT/g, plasma magnesium decreased in 3-day-old newborn rats 3 h after injection. This dose was found to decrease plasma magnesium in the 19·5-day-old foetus and in the 20·5-day-old foetus. Before 19·5 days of gestation no effect was observed.

scholarly journals Magnesium Supplementation Does Not Affect Blood Calcium Level in Treated Hypoparathyroid Patients

2012 ◽  
Vol 97 (11) ◽  
pp. E2090-E2092 ◽  
Author(s):  
Maire Lubi ◽  
Kaia Tammiksaar ◽  
Svetlana Matjus ◽  
Eero Vasar ◽  
Vallo Volke
Keyword(s):  
Calcium Level ◽  
Magnesium Deficiency ◽  
Plasma Calcium ◽  
Endocrine Disorders ◽  
Magnesium Supplementation ◽  
Two Phase ◽  
Blood Calcium ◽  
Clinically Significant ◽  
Plasma Magnesium ◽  
Magnesium Treatment

Context: Magnesium is involved in the homeostasis of calcium metabolism, and magnesium deficiency may lead to clinically significant hypocalcemia. We have had two cases in our department in which treated hypoparathyroid patients with stable calcium levels developed hypercalcemia in conjunction with supplementary magnesium use. To our knowledge, there has been no prospective study looking at the effect of supplementary magnesium on calcium homeostasis in hypoparathyroid patients. Objective: The aim of this pilot study was to evaluate whether magnesium treatment affects plasma calcium levels in hypoparathyroid patients. Design and Setting: We conducted a prospective, two-phase, uncontrolled treatment trial at a referral center of endocrine disorders. Participants: We enrolled treated (calcium + vitamin D analog) hypoparathyroid patients with normal plasma magnesium levels. Intervention: Three weeks of treatment with oral magnesium (350 mg/d) were followed by 2 wk off treatment. Measures: We compared the plasma ionized calcium level after 3 wk of treatment to the pretreatment value. Plasma calcium, phosphate, magnesium, and creatinine levels were measured before treatment, after 3 wk on magnesium, and 2 wk after stopping magnesium treatment. Results: Ten patients completed the trial. Supplementary treatment with magnesium for 3 wk did not change calcium levels in these patients. Magnesium supplementation induced a small but statistically significant increase in the plasma magnesium level, but levels of phosphate and creatinine remained stable. Conclusions: Magnesium supplementation did not influence plasma calcium levels in treated hypoparathyroid patients.

GENERAL EFFECTS OF α-MELANOCYTE STIMULATING HORMONE IN THE RABBIT

1965 ◽  
Vol 48 (4) ◽  
pp. 609-618 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Systemic Effects ◽  
List Type ◽  
Aqueous Flare ◽  
Melanocyte Stimulating Hormone ◽  
Blood Aqueous Barrier

ABSTRACT In addition to the previously described permeability disturbance in the blood aqueous barrier of the eye, measured as an increase of the aqueous flare, a series of transitory systemic effects have been recorded following the subcutaneous injection of synthetic α-MSH: marked increase of the free fatty acids in plasma, decrease in the serum calcium level, decrease in the blood pressure, increase in the skin temperature, increased frequency and diminished amplitude of respiration, presence of slow waves in the EEG. There is a correlation between the magnitude of the aqueous flare increase and the increase of free fatty acids in plasma and also between the aqueous flare and the minimum serum calcium level.

ABOLITION OF MAGNESIUM-INDUCED HYPOCALCAEMIA BY ACUTE THYRO-PARATHYROIDECTOMY IN THE CAT

1970 ◽  
Vol 64 (1) ◽  
pp. 150-158 ◽  
Author(s):  
S. Pors Nielsen
Keyword(s):  
Sodium Chloride ◽  
Flow Rate ◽  
Magnesium Chloride ◽  
Calcium Concentration ◽  
Plasma Calcium ◽  
Magnesium Concentration ◽  
Isotonic Sodium Chloride ◽  
Plasma Calcium Concentration ◽  
High Concentrations ◽  
Plasma Magnesium

ABSTRACT Intravenous infusion of isotonic magnesium chloride into young cats with a resultant mean plasma magnesium concentration of 7.7 meq./100 g protein was followed by a significant lowering of the plasma calcium concentration in 90 minutes. The rate of decrease of plasma calcium is consistent with the hypothesis that calcitonin is released by magnesium in high concentrations. There was no decrease in the plasma calcium concentration in cats of the same weight thyroparathyroidectomized 60 min before an identical magnesium chloride infusion or an infusion of isotonic sodium chloride at the same flow rate. The hypercalciuric effect of magnesium could not account for the hypocalcaemic effect of magnesium. Plasma magnesium concentration during magnesium infusion into cats with an intact thyroid-parathyroid gland complex was slightly, but not significantly higher than in acutely thyroparathyroidectomized cats.

EFFECT OF SUPPLEMENTAL RATION ON CHANGES IN BLOOD COMPONENTS OF STEERS GIVEN ACCESS TO LUSH PASTURE

1971 ◽  
Vol 51 (1) ◽  
pp. 179-186 ◽  
Author(s):  
E. E. LISTER ◽  
W. SZEPESI ◽  
K. A. WINTER ◽  
H. F. JEFFERS ◽  
V. S. LOGAN
Keyword(s):  
Lactic Acid ◽  
Rumen Fluid ◽  
Plasma Calcium ◽  
Lactic Acid Concentration ◽  
Lower Plasma ◽  
Supplemental Feed ◽  
Glucose Levels ◽  
Subsequent Effect ◽  
Calcium And Magnesium ◽  
Plasma Magnesium

Prepasture feeding of low quality hay versus hay and grain had no subsequent effect on rumen fluid ammonia, blood urea, or plasma calcium, glucose and lactic acid concentration in steers turned out on lush pasture. Steers previously fed hay and grain had lower plasma magnesium levels on the first day on unsupplemented pasture than those fed hay prior to pasture. Supplemental feed on pasture partly alleviated the depression in plasma magnesium on the first day on pasture. Feeding supplemental hay with pasture tended to lower rumen fluid ammonia, blood urea and plasma lactic acid compared with feeding no supplement during the initial days on pasture, indicating the desirability of hay feeding during this time. A hay and grain supplement with pasture had a similar effect to the hay supplement on rumen-fluid ammonia, and plasma lactic acid, but a lesser effect on blood urea concentration. Neither supplemental hay nor hay plus grain affected plasma calcium or glucose levels. All steers showed an increase in rumen fluid ammonia, blood urea and plasma lactic acid on the first day and a decrease in plasma calcium and magnesium on the second day on pasture. Blood urea, plasma magnesium and plasma calcium concentrations had not returned to prepasture levels by 21 days on pasture.

Seminal Plasma Calcium in Normal and Infertile Patients

2016 ◽  
Vol 84 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Kalanghot P. Skandhan ◽  
Birendranath Mazumdar ◽  
Balakrishnan Sumangala ◽  
Vasudevan Jaya
Keyword(s):  
Seminal Plasma ◽  
Calcium Level ◽  
Plasma Calcium ◽  
Normal Men ◽  
Infertile Patients

Introduction In this study an attempt is made to find out the level of calcium in seminal plasma of normal and infertile patients. Materials and Methods Semen samples are collected from 34 normal men and 112 infertile patients. After semen evaluation seminal plasma was separated and calcium level was measured in it. Results Calcium level in mg% is recorded in each group as follows; in normozospermia (n34) 20.14 ± 1.25 (±SE), oligozoospermia (n26) 9.76 ± 1.17, azoospermia (n33) 14.65 ± 2.63, oligoasthenozoosperma (n28) 20.91 ± 1.94 and in asthenozoospermia (n25) 11.56 ± 1.68. Statistically highly significant reduction in calcium is seen in Oligozoospermia and asthenozoospermia. Conclusions The probable reasons for these two conditions are discussed.

The response of plasma minerals, free fatty acids and glucose to adrenaline and cortisol infusion in sheep

1986 ◽  
Vol 106 (2) ◽  
pp. 209-217 ◽  
Author(s):  
Sarah C. Bolton ◽  
T. E. C. Weekes
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Marked Decrease ◽  
Plasma Concentrations ◽  
Sodium Concentration ◽  
Plasma Calcium ◽  
Plasma Sodium ◽  
Plasma Phosphate ◽  
Plasma Sodium Concentration ◽  
Plasma Magnesium

SUMMARYAdrenaline was infused at three rates, 40, 15 or 3 μ/kg/h, in normal sheep and in sheep rendered hypercortisolaemic by infusion of cortisol at 150 μg/kg/h. In both normal and hypercortisolaemic animals, plasma concentrations of glucose and free fatty acids were increased by adrenaline treatment; plasma phosphate decreased with all treatments; plasma magnesium and potassium decreased on infusion of adrenaline at 40 or 15, but not at 3 μg/kg/h; plasma calcium decreased only on infusion of adrenaline in hypercortisolaemic animals, and plasma sodium concentration was unaffected by treatment.Induction of a degree of lipolysis likely to occur in the field was not associated with a marked decrease in plasma magnesium.

Morroy Sardà. Function of the parathyroid glands. (Arch. Med. Cirur. J. Espec, Madrid. V. 39, 1936)

1937 ◽  
Vol 33 (1) ◽  
pp. 114-114
Author(s):  
V. Dembskaya
Keyword(s):  
Inorganic Phosphorus ◽  
Parathyroid Glands ◽  
Parathyroid Extract

The authors monitored the changes in organic and inorganic phosphorus and carbohydrates in the muscles of rabbits receiving parathyroid extract and creatinine, separately or simultaneously.

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