scholarly journals Magnesium Supplementation Does Not Affect Blood Calcium Level in Treated Hypoparathyroid Patients

2012 ◽  
Vol 97 (11) ◽  
pp. E2090-E2092 ◽  
Author(s):  
Maire Lubi ◽  
Kaia Tammiksaar ◽  
Svetlana Matjus ◽  
Eero Vasar ◽  
Vallo Volke
Keyword(s):  
Calcium Level ◽  
Magnesium Deficiency ◽  
Plasma Calcium ◽  
Endocrine Disorders ◽  
Magnesium Supplementation ◽  
Two Phase ◽  
Blood Calcium ◽  
Clinically Significant ◽  
Plasma Magnesium ◽  
Magnesium Treatment

Context: Magnesium is involved in the homeostasis of calcium metabolism, and magnesium deficiency may lead to clinically significant hypocalcemia. We have had two cases in our department in which treated hypoparathyroid patients with stable calcium levels developed hypercalcemia in conjunction with supplementary magnesium use. To our knowledge, there has been no prospective study looking at the effect of supplementary magnesium on calcium homeostasis in hypoparathyroid patients. Objective: The aim of this pilot study was to evaluate whether magnesium treatment affects plasma calcium levels in hypoparathyroid patients. Design and Setting: We conducted a prospective, two-phase, uncontrolled treatment trial at a referral center of endocrine disorders. Participants: We enrolled treated (calcium + vitamin D analog) hypoparathyroid patients with normal plasma magnesium levels. Intervention: Three weeks of treatment with oral magnesium (350 mg/d) were followed by 2 wk off treatment. Measures: We compared the plasma ionized calcium level after 3 wk of treatment to the pretreatment value. Plasma calcium, phosphate, magnesium, and creatinine levels were measured before treatment, after 3 wk on magnesium, and 2 wk after stopping magnesium treatment. Results: Ten patients completed the trial. Supplementary treatment with magnesium for 3 wk did not change calcium levels in these patients. Magnesium supplementation induced a small but statistically significant increase in the plasma magnesium level, but levels of phosphate and creatinine remained stable. Conclusions: Magnesium supplementation did not influence plasma calcium levels in treated hypoparathyroid patients.

Magnesium reabsorption in the juxtamedullary loop of Henle: effect of magnesium deprivation

1987 ◽  
Vol 65 (9) ◽  
pp. 1918-1922 ◽  
Author(s):  
Denis R. Roy
Keyword(s):  
Magnesium Deficiency ◽  
Magnesium Concentration ◽  
Control Group ◽  
Loop Of Henle ◽  
Two Phase ◽  
Daily Excretion ◽  
Tightly Coupled ◽  
Magnesium Excretion ◽  
Plasma Magnesium ◽  
Filtered Load

To determine the contribution of the juxtamedullary loop of Henle to magnesium reabsorption during magnesium deficiency, we performed two-phase micropuncture studies of end-descending limbs in a group of magnesium-deficient rats (n = 7) and in a pair-fed control group (n = 8) given MgCl2 in their drinking water. In the magnesium-deficient rats, daily excretion of magnesium fell to very low values (1.2 ± 0.2 vs. 52 ± 12 μM∙day−1∙100 g body weight−1, p < 0.05). Plasma magnesium concentration and fractional magnesium excretion during the control phase were nearly 52 and 27%, respectively, of the values observed in pair-fed controls. Fractional magnesium delivery to the end-descending limb did not differ significantly between the two groups. During the acute magnesium repletion phase, fractional magnesium excretion and fractional magnesium delivery to the end-descending limb increased by a similar value in the two groups of rats, despite a lower filtered load of magnesium in the magnesium-deficient group. Absolute magnesium reabsorption upstream to the end-descending limb was lower in the magnesium-deficient rats but was otherwise tightly coupled to the filtered load of magnesium (Y = 0.91 + 0.37 x, r = 0.82, p < 0.05). Similar observations were made with regards to whole kidney magnesium reabsoiption. Our results suggest that, in young magnesium-deficient rats, magnesium reabsorption is tightly coupled to the filtered load of magnesium both in segments upstream to the juxtamedullary end-descending limb and in the whole kidney, and that a reabsorptive defect for magnesium is not evident in this setting.

Effects of conventional daily magnesium supplementation, breed of ewe and continued potassium fertilizer applications on plasma magnesium and calcium levels of ewes

1963 ◽  
Vol 61 (3) ◽  
pp. 411-415 ◽  
Author(s):  
N. S. Ritchie ◽  
R. G. Hemingway
Keyword(s):  
Magnesium Level ◽  
Plasma Calcium ◽  
Potassium Fertilizer ◽  
Lower Plasma ◽  
Magnesium Supplementation ◽  
Before And After ◽  
The Mean ◽  
Calcium And Magnesium ◽  
Plasma Magnesium ◽  
Muriate Of Potash

1. Muriate of potash applied at rates of 0, 1 and 2 cwt./acre to herbage which had also received similar treatments in the previous year did not influence plasma magnesium or calcium values in lactating ewes.2. 24 Cheviot ewes had slightly lower plasma calcium and magnesium levels than 24 Half-bred ewes of the same age both before and after lambing.3. 6·6 g. of magnesium oxide given as a daily drench did not increase plasma magnesium values as measured by blood samples taken 24 hr. after drenching. Values were however increased by 0·5 mg. Mg/100 ml. four hours after drenching.4. No clinical cases of hypomagnesaemic tetany occurred, even although the mean plasma magnesium level of all the ewes in the experiment was only about 1·0 mg./lOO ml.5. Plasma magnesium values of ewes before lambing were significantly (P < 0·001) correlated with post-lambing levels. Values for the ewes during 1962 were equally significantly correlated with levels for the same sheep at comparable dates in 1961.

Effects of potassium fertilizers, age of ewe, and small magnesium supplementation on blood magnesium and calcium levels of lactating ewes

1963 ◽  
Vol 60 (3) ◽  
pp. 307-312 ◽  
Author(s):  
R. G. Hemingway ◽  
N. S. Ritchie ◽  
A. R. Rutherford ◽  
G. M. Jolly
Keyword(s):  
Clinical Case ◽  
Experimental Period ◽  
Plasma Calcium ◽  
Large Individual ◽  
Potassium Fertilizer ◽  
Lower Plasma ◽  
Magnesium Supplementation ◽  
Fertilizer Use ◽  
Plasma Magnesium ◽  
Muriate Of Potash

1. An experiment is described which investigated the effects of potassium fertilizer, age of ewe, and a small magnesium supplement, on the plasma magnesium and calcium levels of ewes shortly after lambing.2. Three potassium treatments (0, 1, and 2 cwt. muriate of potash/acre) were used, each being replicated six times, which gave a total of eighteen plots. Each plot was grazed by two old and two young ewes. One ewe of each age in every plot was given supplementary magnesium in the form of two magnesium heavy pellets, which released a total of 150 mg. Mg/day.3. 22% of the ewes had plasma magnesium values below 1·0 mg. Mg/100 ml. on at least one sampling occasion during the experimental period. There was only one clinical case of tetany.4. Neither potassium fertilizer use, nor magnesium supplementation influenced plasma magnesium and calcium levels of the ewes. Old ewes had greater temporary falls in plasma magnesium values and had consistently lower plasma calcium values.5. Attention is drawn to the large individual variation between animals and the consequent need for providing adequate statistical analysis of experiments of this type.

EVIDENCE FOR A CALCITONIN EFFECT IN MAN.

1965 ◽  
Vol 48 (1) ◽  
pp. 132-136 ◽  
Author(s):  
Heinrich G. Haas ◽  
Heinz Affolter ◽  
Ulrich C. Dubach
Keyword(s):  
Calcium Level ◽  
Plasma Calcium ◽  
Parathyroid Glands ◽  
List Type ◽  
Parathyroid Extract ◽  
Plasma Magnesium ◽  
Subsequent Rise

ABSTRACT In 1962 Copp et al. (1962) demonstrated a second, plasma calcium lowering factor from the parathyroid glands called calcitonin. These findings were subsequently confirmed by Kumar et al. (1963). Up to the present, however, calcitonin has not been demonstrated in man. In a patient with hypocalcaemic tetany the injection of a commercial parathyroid extract caused the same changes in plasma calcium as described by Copp et al. (1962) in dogs, i. e. an initial fall and a subsequent rise in the calcium level. In addition, changes in plasma magnesium paralleling those of calcium were also observed.

ABOLITION OF MAGNESIUM-INDUCED HYPOCALCAEMIA BY ACUTE THYRO-PARATHYROIDECTOMY IN THE CAT

1970 ◽  
Vol 64 (1) ◽  
pp. 150-158 ◽  
Author(s):  
S. Pors Nielsen
Keyword(s):  
Sodium Chloride ◽  
Flow Rate ◽  
Magnesium Chloride ◽  
Calcium Concentration ◽  
Plasma Calcium ◽  
Magnesium Concentration ◽  
Isotonic Sodium Chloride ◽  
Plasma Calcium Concentration ◽  
High Concentrations ◽  
Plasma Magnesium

ABSTRACT Intravenous infusion of isotonic magnesium chloride into young cats with a resultant mean plasma magnesium concentration of 7.7 meq./100 g protein was followed by a significant lowering of the plasma calcium concentration in 90 minutes. The rate of decrease of plasma calcium is consistent with the hypothesis that calcitonin is released by magnesium in high concentrations. There was no decrease in the plasma calcium concentration in cats of the same weight thyroparathyroidectomized 60 min before an identical magnesium chloride infusion or an infusion of isotonic sodium chloride at the same flow rate. The hypercalciuric effect of magnesium could not account for the hypocalcaemic effect of magnesium. Plasma magnesium concentration during magnesium infusion into cats with an intact thyroid-parathyroid gland complex was slightly, but not significantly higher than in acutely thyroparathyroidectomized cats.

scholarly journals Magnesium and Hypertension in Old Age

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 139 ◽  
Author(s):  
Ligia J. Dominguez ◽  
Nicola Veronese ◽  
Mario Barbagallo
Keyword(s):  
Older Persons ◽  
Magnesium Deficiency ◽  
Favorable Effect ◽  
Processed Food ◽  
Negative Consequences ◽  
Magnesium Supplementation ◽  
Cerebrovascular Complications ◽  
Close Relationship ◽  
Causes Of Mortality

Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In the last decades, there has been an exceptional amount of experimental, epidemiological, and clinical studies confirming a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, avoiding processed food, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated.

EFFECT OF SUPPLEMENTAL RATION ON CHANGES IN BLOOD COMPONENTS OF STEERS GIVEN ACCESS TO LUSH PASTURE

1971 ◽  
Vol 51 (1) ◽  
pp. 179-186 ◽  
Author(s):  
E. E. LISTER ◽  
W. SZEPESI ◽  
K. A. WINTER ◽  
H. F. JEFFERS ◽  
V. S. LOGAN
Keyword(s):  
Lactic Acid ◽  
Rumen Fluid ◽  
Plasma Calcium ◽  
Lactic Acid Concentration ◽  
Lower Plasma ◽  
Supplemental Feed ◽  
Glucose Levels ◽  
Subsequent Effect ◽  
Calcium And Magnesium ◽  
Plasma Magnesium

Prepasture feeding of low quality hay versus hay and grain had no subsequent effect on rumen fluid ammonia, blood urea, or plasma calcium, glucose and lactic acid concentration in steers turned out on lush pasture. Steers previously fed hay and grain had lower plasma magnesium levels on the first day on unsupplemented pasture than those fed hay prior to pasture. Supplemental feed on pasture partly alleviated the depression in plasma magnesium on the first day on pasture. Feeding supplemental hay with pasture tended to lower rumen fluid ammonia, blood urea and plasma lactic acid compared with feeding no supplement during the initial days on pasture, indicating the desirability of hay feeding during this time. A hay and grain supplement with pasture had a similar effect to the hay supplement on rumen-fluid ammonia, and plasma lactic acid, but a lesser effect on blood urea concentration. Neither supplemental hay nor hay plus grain affected plasma calcium or glucose levels. All steers showed an increase in rumen fluid ammonia, blood urea and plasma lactic acid on the first day and a decrease in plasma calcium and magnesium on the second day on pasture. Blood urea, plasma magnesium and plasma calcium concentrations had not returned to prepasture levels by 21 days on pasture.

Seminal Plasma Calcium in Normal and Infertile Patients

2016 ◽  
Vol 84 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Kalanghot P. Skandhan ◽  
Birendranath Mazumdar ◽  
Balakrishnan Sumangala ◽  
Vasudevan Jaya
Keyword(s):  
Seminal Plasma ◽  
Calcium Level ◽  
Plasma Calcium ◽  
Normal Men ◽  
Infertile Patients

Introduction In this study an attempt is made to find out the level of calcium in seminal plasma of normal and infertile patients. Materials and Methods Semen samples are collected from 34 normal men and 112 infertile patients. After semen evaluation seminal plasma was separated and calcium level was measured in it. Results Calcium level in mg% is recorded in each group as follows; in normozospermia (n34) 20.14 ± 1.25 (±SE), oligozoospermia (n26) 9.76 ± 1.17, azoospermia (n33) 14.65 ± 2.63, oligoasthenozoosperma (n28) 20.91 ± 1.94 and in asthenozoospermia (n25) 11.56 ± 1.68. Statistically highly significant reduction in calcium is seen in Oligozoospermia and asthenozoospermia. Conclusions The probable reasons for these two conditions are discussed.

The response of plasma minerals, free fatty acids and glucose to adrenaline and cortisol infusion in sheep

1986 ◽  
Vol 106 (2) ◽  
pp. 209-217 ◽  
Author(s):  
Sarah C. Bolton ◽  
T. E. C. Weekes
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Marked Decrease ◽  
Plasma Concentrations ◽  
Sodium Concentration ◽  
Plasma Calcium ◽  
Plasma Sodium ◽  
Plasma Phosphate ◽  
Plasma Sodium Concentration ◽  
Plasma Magnesium

SUMMARYAdrenaline was infused at three rates, 40, 15 or 3 μ/kg/h, in normal sheep and in sheep rendered hypercortisolaemic by infusion of cortisol at 150 μg/kg/h. In both normal and hypercortisolaemic animals, plasma concentrations of glucose and free fatty acids were increased by adrenaline treatment; plasma phosphate decreased with all treatments; plasma magnesium and potassium decreased on infusion of adrenaline at 40 or 15, but not at 3 μg/kg/h; plasma calcium decreased only on infusion of adrenaline in hypercortisolaemic animals, and plasma sodium concentration was unaffected by treatment.Induction of a degree of lipolysis likely to occur in the field was not associated with a marked decrease in plasma magnesium.

Sign in / Sign up

Export Citation Format

Share Document