IN VITRO METABOLISM OF 17α-METHYL-1 9-NORTESTOSTERONE BY FEMALE RAT LIVER HOMOGENATE

1964 ◽  
Vol 46 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Hiroji Okada ◽  
Kichisaburo Matsuyoshi ◽  
Gen-ichi Tokuda
Keyword(s):  
Rat Liver ◽  
Liver Homogenate ◽  
In Vitro Metabolism ◽  
Female Rat

ABSTRACT Incubation of 17α-methyl-19-nortestosterone-3H with female rat liver homogenate resulted in the formation of 17α-methyl-19-norandrostan-17β-ol-3-one-3H and 17α-methyl-19-norandrostane-3α,17β-diol-3H.

Centchroman: In vitro metabolism by rat liver homogenate

1986 ◽  
Vol 7 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Sanjeev Ratna ◽  
S. K. Roy ◽  
Suprabhat Ray ◽  
P. L. Kole ◽  
M. Salman ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Homogenate ◽  
In Vitro Metabolism

scholarly journals Metabolism in Vitro of 19-Nortestosterone in Female Rat Liver Homogenate

1960 ◽  
Vol 235 (7) ◽  
pp. 1968-1969
Author(s):  
David Kupfer ◽  
Enrico Forchielli ◽  
Ralph I. Dorfman
Keyword(s):  
Rat Liver ◽  
Liver Homogenate ◽  
Female Rat

scholarly journals The Metabolic Fate of ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride (C-78). III. In Vitro Metabolism in Rat Liver

1977 ◽  
Vol 97 (3) ◽  
pp. 231-236
Author(s):  
YUZURU YAMAMOTO ◽  
KEIICHI NITTA ◽  
TOSHIAKI FUJIHASHI ◽  
IKUO UESAKA ◽  
KAZUNORI NISHIDE
Keyword(s):  
Benzyl Alcohol ◽  
Rat Liver ◽  
In Vitro Metabolism ◽  
Metabolic Fate ◽  
C 78

In vitro metabolism in Sprague–Dawley rat liver microsomes of forsythoside A in different compositions of Shuang–Huang–Lian

Fitoterapia ◽  
2011 ◽  
Vol 82 (8) ◽  
pp. 1222-1230 ◽  
Author(s):  
Wei Zhou ◽  
Liu-qing Di ◽  
Jin-jun Shan ◽  
Xiao-lin Bi ◽  
Le-tian Chen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

scholarly journals Differences in size, structure and function of free and membrane-bound polyribosomes of rat liver. Evidence for a single class of membrane-bound polyribosomes

1977 ◽  
Vol 168 (1) ◽  
pp. 1-8 ◽  
Author(s):  
J C Ramsey ◽  
W J Steele
Keyword(s):  
Protein Synthesis ◽  
Rat Liver ◽  
Size Structure ◽  
Large Fraction ◽  
Liver Homogenate ◽  
Structure And Function ◽  
Structural And Functional Properties ◽  
Membrane Bound ◽  
And Function

Free loosely bound and tightly bound polyribosomes were separated from rat liver homogenate by salt extraction followed by differential centrifugation, and several of their structural and functional properties were compared to resolve the existence of loosely bound polyribosomes and verify the specificity of the separation. The free and loosely bound polyribosomes have similar sedimentation profiles and polyribosome contents, their subunit proteins have similar electrophoretic patterns and their products of protein synthesis in vitro show a close correspondence in size and amounts synthesized. In contrast, the tightly bound polyribosomes have different properties from those of the free and loosely bound polyribosomes; their average size is significantly smaller; their polyribosome content is higher; their 60 S-subunit proteins lack two components and contain four or more components not found elsewhere; their products of protein synthesis in vitro differ in size and amounts synthesized. These observations show that rat liver membranes entrap a large fraction of the free polyribosomes at low salt concentrations and that these polyribosomes are similar to those of the free-polyribosome fraction and are different from those of the tightly bound polyribosome fraction in size, structure and function.

A STUDY ON THE "IN VITRO" SYNTHESIS OF CITRULLINE: PART II. EFFECT OF GLUTAMIC ACID AND DERIVATIVES IN THE PRESENCE OF FUMARIC ACID

1964 ◽  
Vol 42 (9) ◽  
pp. 1325-1330 ◽  
Author(s):  
René Charbonneau ◽  
Louis Berlinguet
Keyword(s):  
Glutamic Acid ◽  
Rat Liver ◽  
Fumaric Acid ◽  
Liver Homogenate ◽  
Particulate Fraction ◽  
In Vitro Synthesis ◽  
System L ◽  
Acyl Derivatives

The role of N-carbamyl, N-acetyl, and L-glutamic acids with and without fumaric acid on the "in vitro" synthesis of citrulline was studied by using a particulate fraction obtained from a rat liver homogenate and a partially purified citrulline-synthesizing enzyme system. In the presence of a particulate fraction of rat liver homogenate, N-carbamyl and N-acetyl-L-glutamic acids are unable to replace L-glutamic acid, which is essential for citrulline biosynthesis. However, in the presence of fumaric acid, they both give a better synthesis of citrulline than L-glutamic acid alone. It is postulated that the acyl derivatives serve only in the transport of "activated CO2" whereas fumaric acid enters the citric acid to furnish the essential ATP molecules. Glutamic acid would be able to perform both functions. However, in the presence of a system containing partially purified citrulline-synthesizing enzymes, L-glutamic acid is unable to replace N-carbamyl and N-acetyl-L-glutamic acids with or without fumaric acid. In such a system, L-glutamic acid cannot serve in the transport of "activated CO2". It is postulated that L-glutamic acid must be acetylated prior to its utilization in this respect.With the particulate fraction of rat liver homogenate, N-allyl aspartic acid inhibits totally the synthesis of citrulline both in the presence and absence of fumaric acid with or without glutamic or N-acetyl glutamic acids. It probably interferes with the transport of "activated CO2".

Effect of Prolonged Consumption of Pemmican Survival Ration on Some Aspects of the Intermediary Metabolism of Rat Liver Tissue

1958 ◽  
Vol 193 (2) ◽  
pp. 449-454 ◽  
Author(s):  
John P. Hannon ◽  
David A. Vaughan
Keyword(s):  
Cytochrome C ◽  
Respiratory Rate ◽  
Rat Liver ◽  
Liver Tissue ◽  
In Vitro Metabolism ◽  
Intermediary Metabolism ◽  
Normal Value ◽  
Endogenous Metabolism ◽  
Prolonged Feeding

The effect of prolonged feeding (3–5 months) of pemmican on some aspects of the in vitro metabolism of liver tissue was investigated. The endogenous metabolism of liver slices and homogenates was significantly increased by pemmican, probably due to an increase in the amount of readily metabolizable substrate. Utilizing mitochondrial preparations, it was found that with all substrates studied, except glutamate, α-ketoglutarate and succinate, the respiratory rate was not affected by the previous diet in the absence of added cytochrome c and diphosphopyridine nucleotide. The three substrates mentioned were oxidized at significantly lower rates in the pemmican group. Upon the addition of cytochrome c and diphosphopyridine nucleotide the qo2 of glutamate, α-ketoglutarate, and succinate was returned to the normal value.

scholarly journals In Vitro Metabolism of Testosterone Sulfate and Testosterone Tetrahydropyranyl Ether in Male Rat Liver

1973 ◽  
Vol 21 (3) ◽  
pp. 558-564 ◽  
Author(s):  
MICHIO MATSUI ◽  
FUKUO ABE ◽  
MIDORI KUNIKANE ◽  
MASASHI OKADA
Keyword(s):  
Rat Liver ◽  
In Vitro Metabolism ◽  
Male Rat ◽  
Tetrahydropyranyl Ether
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