ON THE EFFECT OF LONG-ACTING CORTICOTROPHIN PREPARATIONS

1963 ◽  
Vol 43 (4) ◽  
pp. 499-509 ◽  
Author(s):  
Pavo Hedner
Keyword(s):  
Diurnal Rhythm ◽  
Carboxymethyl Cellulose ◽  
Animal Experiments ◽  
Zinc Hydroxide ◽  
Dexamethasone Treatment ◽  
Short Term ◽  
Low Level ◽  
Long Acting

ABSTRACT The effect of addition of carboxymethyl cellulose, gelatine, polyphloretin phosphate and zinc hydroxide to corticotrophin was studied by means of fluorimetric plasma corticosteroid determinations in man and rats. The plasma corticosteroid level was stabilized at a low level by the administration of dexamethasone. Two days after a 3 day period of dexamethasone, 2 mg × 4 orally, the volunteers had a normal diurnal rhythm of plasma corticosteroid level indicating that short term dexamethasone treatment may be given without any serious risks. For each type of experiment, the same corticotrophin was employed to avoid dose differences. Each subject was injected with each preparation at weekly intervals. Significant differences between individuals were observed. The effect of polyphloretin phosphate exceeded that of gelatine, both substances significantly exceeding that of carboxymethyl cellulose and zinc hydroxide 8 hours after the injection and subsequently. Similar results were obtained in animal experiments.

scholarly journals Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice

2006 ◽  
Vol 43 (4) ◽  
pp. 809-815 ◽  
Author(s):  
Abbey Schepers ◽  
Nuno M.M. Pires ◽  
Daniel Eefting ◽  
Margreet R. de Vries ◽  
J. Hajo van Bockel ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Vein Graft ◽  
Dexamethasone Treatment ◽  
Short Term

ANALYSIS OF THE NATURE OF THE EUROPEAN DIGITAL TAX IN COMPARISON WITH THE CURRENT VAT SYSTEM AND ITS IMPACT ON THE ECONOMY AND MANAGEMENT OF ECONOMIC ENTITIES

2021 ◽  
Vol 2 (4) ◽  
pp. 42-48
Author(s):  
S. V. ZAYTSEV ◽  
Keyword(s):  
European Union ◽  
Civil Society ◽  
European Commission ◽  
Value Added ◽  
The European Union ◽  
Value Added Tax ◽  
Short Term ◽  
Low Level ◽  
Digital Services ◽  
The Many

In March 2018 the European Commission presented a proposal to adopt a digital services tax (DST) on certain types of revenues of multinational digital Companies. The purpose of the digital services tax is to compensate in the short term for the low level of corporate taxation of these companies in the European Union and thus meet the urgent need of civil society for greater tax fairness. DST is presented as an indirect tax on turnover and is often compared to value-added tax (VAT). In this article, the author seeks to highlight the many differences that exist between the harmonized European Union VAT and the new DST. In addition, the author challenges the idea that the DST will actually be an indirect tax and, most importantly, that it will effectively increase tax justice in the European Union.

scholarly journals 1021. HIV-1 RNA Blips and Low-Level Replication During Phase III/IIIb Cabotegravir + Rilpivirine Long-Acting Studies Are Similar to Oral 3-Drug Therapy and Not Associated with Week 48 Virologic Outcome

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S540-S541
Author(s):  
Christine L Talarico ◽  
Sterling Wu ◽  
Ojesh R Upadhyay ◽  
Marty St Clair ◽  
Veerle Van Eygen ◽  
...  
Keyword(s):  
Viral Load ◽  
Virologic Failure ◽  
Phase Iii ◽  
Individual Study ◽  
Treatment Groups ◽  
Qualitative And Quantitative ◽  
Low Level ◽  
Long Acting ◽  
Study Participants ◽  
Hiv 1

Abstract Background Phase III/IIIb studies demonstrated cabotegravir (CAB) + rilpivirine (RPV) long-acting (LA) dosed every 4 weeks (Q4W) was noninferior to current antiviral regimen (CAR) (FLAIR and ATLAS) and CAB + RPV LA dosed every 8 weeks (Q8W) was noninferior to Q4W (ATLAS-2M) through Week 48 (W48). HIV-1 ribonucleic acid (RNA) blips (viral load [VL] ≥50 to < 200 c/mL) are common during antiretroviral therapy (ART) and generally not associated with subsequent virologic failure (2 consecutive HIV-1 RNA ≥200 c/mL). We compared the frequency of HIV-1 RNA blips and low-level qualitative and quantitative HIV-1 RNA replication among participants treated with CAB+RPV LA and oral CAR and assessed impact on virologic outcome. Methods Plasma samples collected at study visits were analyzed for HIV-1 RNA viral load using the Abbott RealTime HIV-1 assay and qualitative target detected (TD) or target not detected (TND) outcomes were provided for HIV-1 RNA < 40 c/mL. The HIV-1 SuperLow assay (bioMONTR Labs) was used to measure HIV-1 RNA < 2 c/mL at Baseline and W48. Results The proportion of participants with HIV-1 RNA blips was similar overall between Q4W CAB + RPV LA and CAR arms in FLAIR (38/283 [13%] vs 39/283 [14%]) and ATLAS (17/308 [6%] vs 23/308 [7%]). Presence of HIV-1 RNA blips in either arm was not associated with virologic non-response at W48 (HIV-1 RNA ≥50 c/mL per US Food and Drug Administration Snapshot). In ATLAS-2M, HIV-1 RNA blips were observed in 32/523 (6%; Q4W) and 18/522 (3%; Q8W) of participants, with W48 virologic nonresponse in 2 Q4W and 0 Q8W participants. TD outcomes at individual study visits were comparable between study arms for the 3 studies. At W48, the proportion of participants with HIV-1 RNA < 2 c/mL was similar to Baseline and similar between treatment groups in all studies. Conclusion The proportions of study participants with HIV-1 RNA blips, TD viral load results, and HIV-1 < 2 c/mL were similar between the Q4W and Q8W CAB+RPV LA and the oral 3-drug CAR arms through W48 in phase III/IIIb studies. HIV-1 RNA blips did not predict virologic nonresponse (Snapshot analysis) at W48. Disclosures Christine L. Talarico, M.S, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) Sterling Wu, PhD, GlaxoSmithKline (Employee, Shareholder) Marty St. Clair, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) Veerle Van Eygen, MSc, Janssen Pharmaceutica NV (Employee) Krischan J. Hudson, PhD, MPH, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) Sandy Griffith, PharmD, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) Conn M. Harrington, BA, ViiV Healthcare (Employee) Jan van Lunzen, MD, PhD, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) David Margolis, MD, MPH, GlaxoSmithKline (Shareholder)ViiV Healthcare (Employee) William Spreen, PharmD, ViiV Healthcare (Employee, Shareholder)

scholarly journals Gambaran Profil Psikologis Psychopathy Symptoms pada Tahanan Wanita Kasus Korupsi di Lapas Wanita Kelas IIA Sukamiskin Bandung

MANASA ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 98-106
Author(s):  
Medwin Wisnu Prabowo
Keyword(s):  
Marital Relationships ◽  
Middle Level ◽  
Work Setting ◽  
Female Inmates ◽  
Short Term ◽  
Good Relationship ◽  
Low Level ◽  
The Law ◽  
To Receive ◽  
Harmonious Family

There are many crimes that happened in this era, which one of them is corruption. Corruption has become a major phenomenon for each country in this world. Even more, it is not only male who doing the corruption, but female also. They were get some money to satisfy themselves although they have to break the law. This phenomenon has attracted researcher to study the female inmates who was doing corruption, and its relation to psychopathic symptom. Three female inmates in Sukamiskin Penitentiary Institute Class IIA – Bandung, who were convicted based on corruption cases, were chosen as subjects of this study. The result showed that all of three female inmates have a tendency to become a Psychopath, but in the low level to middle level tendencies. The three dominant Psychopathic Symptoms that found: pathological lying, lack of remorse or guilt, and short-term marital relationships. It can be summarized and recommended that among 3 subjects need to receive a counseling and/or psychoeducation so they will be more honest in their work setting, and to educate them that its important to have a good relationship to build a harmonious family.

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