THE SERUM PROTEINS IN DIABETES MELLITUS IN RELATION TO VASCULAR COMPLICATIONS

1963 ◽  
Vol 43 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Bengt Skanse
Keyword(s):  
Diabetes Mellitus ◽  
Serum Protein ◽  
Serum Proteins ◽  
Protein Pattern ◽  
Vascular Complications ◽  
Electrophoretic Analysis ◽  
List Type ◽  
Globulin Fraction ◽  
Patients With Diabetes ◽  
Γ Globulins

ABSTRACT Electrophoretic analysis of the serum protein pattern in 110 patients with diabetes mellitus of varying duration and severity confirmed that the α2-globulins are often increased and that the albumin is often decreased. It was found that the γ-globulins may either be decreased or increased. When the β-globulins are increased, the increase is due to an increase of the β2-globulin fraction. The incidence of the protein changes is about equal in patients with and without vascular complications.

scholarly journals Serum protein electrophoretic pattern in piglets during the early postnatal period

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Csilla Tóthová ◽  
Robert Link ◽  
Petronela Kyzeková ◽  
Oskar Nagy
Keyword(s):  
Serum Protein ◽  
Serum Proteins ◽  
Protein Pattern ◽  
Electrophoretic Pattern ◽  
Postnatal Period ◽  
Early Postnatal Period ◽  
Total Proteins ◽  
Newborn Piglets ◽  
Γ Globulins ◽  
Protein Electrophoretic Pattern

AbstractThe pattern of serum proteins, the typical features of the electrophoretogram in newborn piglets and during their postnatal development is not completely described. Therefore, the aim of this study was to characterize the changes in serum protein electrophoretic pattern and features of the electrophoretograms during the early postnatal period. Significant changes during the monitored period were found in all evaluated parameters (P < 0.001). The most marked changes were observed mainly in the period before weaning. The concentrations of total proteins, albumin and γ-globulins were before colostrum intake low, γ-globulins represented the smallest proportion of protein fractions. The proportion of α1-globulins was after birth a dominant protein fraction. Significant increase of total proteins, α2-, β- and γ-globulins and decrease of α1-globulins was found 2 days after colostrum intake. The albumin and A/G values increased after birth gradually until weaning. After weaning a significant changes were found in absolute concentrations of total protein and albumin, and in relative values of β-globulin fractions. Presented results showed marked developmental alterations in the serum protein pattern in piglets along with the age. The study also brings new knowledge in the field of description of typical features of electrophoretograms in the observed period of piglet’s life.

scholarly journals Pasireotide in an insulin-requiring diabetic acromegalic patient without worsening of hyperglycemia

2017 ◽  
Vol 2017 ◽  
Author(s):  
Murray B Gordon ◽  
Kellie L Spiller
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
List Type ◽  
Effective Treatment Option ◽  
Patients With Diabetes ◽  
Long Acting ◽  
Learning Points

Summary Long-acting pasireotide is an effective treatment option for acromegaly, but it is associated with hyperglycemia, which could impact its use in patients with diabetes. We present a case of a 53-year-old man with acromegaly and type 2 diabetes mellitus (glycated hemoglobin (HbA1c): 7.5%), who refused surgery to remove a pituitary macroadenoma and enrolled in a Phase 3 clinical trial comparing long-acting pasireotide and long-acting octreotide in acromegalic patients. The patient initially received octreotide, but insulin-like growth factor 1 (IGF-1) levels remained elevated after 12 months (383.9 ng/mL; 193.0 ng/mL; reference range: 86.5–223.8 ng/mL), indicating uncontrolled acromegaly. He switched to pasireotide 40 mg and subsequently increased to 60 mg. Within 6 months, IGF-1 levels normalized (193.0 ng/mL), and they were mostly normal for the next 62 months of treatment with pasireotide (median IGF-1: 190.7 ng/mL). Additionally, HbA1c levels remained similar to or lower than baseline levels (range, 6.7% to 7.8%) during treatment with pasireotide despite major changes to the patient’s antidiabetic regimen, which included insulin and metformin. Uncontrolled acromegaly can result in hyperglycemia due to an increase in insulin resistance. Despite having insulin-requiring type 2 diabetes, the patient presented here did not experience a long-term increase in HbA1c levels upon initiating pasireotide, likely because long-term control of acromegaly resulted in increased insulin sensitivity. This case highlights the utility of long-acting pasireotide to treat acromegaly in patients whose levels were uncontrolled after long-acting octreotide and who manage diabetes with insulin. Learning points Long-acting pasireotide provided adequate, long-term biochemical control of acromegaly in a patient with insulin-requiring type 2 diabetes mellitus who was unresponsive to long-acting octreotide. Glycemic levels initially increased after starting treatment with pasireotide but quickly stabilized as acromegaly became controlled. Long-acting pasireotide, along with an appropriate antidiabetic regimen, may be a suitable therapy for patients with acromegaly who also have insulin-requiring type 2 diabetes mellitus.

EFFECTS OF PORCINE IMMUNE GLOBULIN ADMINISTRATION ON THE SURVIVAL AND SERUM PROTEIN COMPOSITION OF COLOSTRUM-DEPRIVED PIGS REARED IN A NON-ISOLATED ENVIRONMENT

1961 ◽  
Vol 41 (2) ◽  
pp. 236-252 ◽  
Author(s):  
B. D. Owen ◽  
J. M. Bell ◽  
C. M. Williams ◽  
R. G. Oakes
Keyword(s):  
Oral Administration ◽  
Serum Protein ◽  
Immune Globulin ◽  
Serum Proteins ◽  
Protein Pattern ◽  
Post Partum ◽  
Protein Composition ◽  
Paper Strip ◽  
Percentage Survival ◽  
Immune Globulins

Five experiments involving 90 newborn colostrum-deprived pigs were conducted in an attempt to develop a method of rearing applicable in a non-isolated environment. Immune globulins, prepared by ammonium sulphate fractionation of porcine serum, and comprised of a mixture of approximately 75 per cent γ-globulin and 25 per cent β-globulin, were administered orally or parenterally in varying amounts and for varying periods of time. In two experiments porcine albumin, in serum or in a semi-purified solution, was provided in addition to the immune globulins. The distribution of serum proteins in the pigs was studied from birth to 12 weeks of age by paper strip electrophoresis.Parenteral administration of immune globulins did not provide an effective passive immunity, nor did oral administration for 1 day post-partum. A marked improvement in survival occurred when oral administration was continued for 5 days, and it was further found that this treatment provided apparently complete protection against infection during the 5-day period of administration. Albumin appeared to further improve survival.These results, together with the relatively poor survival obtained with positive control pigs (nursed 24 hours) suggested a continuing need for a supply of immune globulins in the lumen of the intestinal tract. Presumably these globulins were active as coproantibodies.The percentage survival in pigs weighing 3 pounds or more at birth was substantially higher than in smaller pigs. Mortality in these experiments was usually attributable to colibacillosis.Serum immune globulin levels at 2 days of age in the artificially reared pigs were elevated in proportion to the amount of globulins given. The effect of albumin was to create a serum protein pattern resembling that of suckled pigs. A marked decline in γ-globulin levels from 2 days to approximately 6 weeks was observed.

scholarly journals Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient

2019 ◽  
Vol 2019 ◽  
Author(s):  
Yael Lefkovits ◽  
Amanda Adler
Keyword(s):  
Diabetes Mellitus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Central Area ◽  
Clinical Suspicion ◽  
High Index ◽  
List Type ◽  
Necrobiosis Lipoidica ◽  
Patients With Diabetes

Summary Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3–1.2% of patients with diabetes mellitus (1). The lesions are often yellow or brown with telangiectatic plaque, a central area of atrophy and raised violaceous borders (2). Similar to other conditions with a high risk of scarring including burns, stasis ulcers and lupus vulgaris, NLD provides a favourable environment for squamous cell carcinoma (SCC) formation (3). A number of cases of SCC from NLD have been recorded (3, 4, 5); however, our search of the literature failed to identify any cases of either metastatic or fatal SCC which developed within an area of NLD. This article describes a patient with established type 1 diabetes mellitus who died from SCC which developed from an area of NLD present for over 10 years. Currently, there are a paucity of recommendations in the medical literature for screening people with NLD for the early diagnosis of SCC. We believe that clinicians should regard non-healing ulcers in the setting of NLD with a high index of clinical suspicion for SCC, and an early biopsy of such lesions should be recommended. Learning points: Non-healing, recalcitrant ulcers arising from necrobiosis lipoidica diabeticorum, which fail to heal by conservative measures, should be regarded with a high index of clinical suspicion for malignancy. If squamous cell carcinoma is suspected, a biopsy should be performed as soon as possible to prevent metastatic spread, amputation or even death. Our literature search failed to reveal specific recommendations for screening and follow-up of non-healing recalcitrant ulcers in the setting of necrobiosis lipoidica diabeticorum. Further research is required in this field.

scholarly journals Blood serum protein in periparturient goats supplemented with various forms of zinc

2016 ◽  
Vol 85 (4) ◽  
pp. 387-394 ◽  
Author(s):  
Lenka Kudělková ◽  
Leoš Pavlata ◽  
Alena Pechová ◽  
Jaroslav Filípek
Keyword(s):  
Blood Serum ◽  
Serum Protein ◽  
Serum Proteins ◽  
Protein Profile ◽  
Electrophoretic Analysis ◽  
Positive Influence ◽  
Protein Fractions ◽  
Negative Effects ◽  
Individual Protein ◽  
Group B

The aim of the study was to compare the contents of individual protein fractions determined by electrophoresis in the blood serum of 32 periparturient goats supplemented with various forms of zinc (Zn). Goats were divided into four groups: Group A was a control (without Zn supplementation). The remaining three groups (B, C, D) were supplemented with Zn in various forms. Group B was supplemented with zinc oxide, Group C with zinc lactate, and Group D with zinc chelate. Individual protein fractions (albumins, α1, α2, β1, β2 a γ-globulins) were identified by electrophoretic analysis. All supplemented groups showed the trend of a positive influence of Zn on γG fractions in the serum protein of the goats; this tendency was significant only in Group C. Moreover, Group C had significantly the highest total protein values and albumins. The results indicated that a feed enriched with various forms of Zn had a significant influence on the quantity of individual protein fractions of blood serum. Our results provide new knowledge on the values of individual protein fractions of serum goats and should be taken into consideration when interpreting the serum protein profile with regard to periparturient goats. Furthermore, we showed the possible positive or negative effects on the values of individual fraction on serum proteins with organic and inorganic zinc form supplemented rich in diet.

scholarly journals Diabetic Foot Spa Implementation in Early Neuropathy Diagnosis Based on Blood Glucose Levels, Foot Sensitivity and the Ankle Brachial Index in Patients with Diabetes Mellitus

Jurnal NERS ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 106
Author(s):  
Erika Martining Wardani ◽  
Chilyatiz Zahroh ◽  
Nur Ainiyah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Foot ◽  
Ankle Brachial Index ◽  
Vascular Complications ◽  
P Value ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Foot Problems

Introduction: Diabetes Mellitus (DM) is a cause of morbidity mainly due to vascular complications. The prevention of diabetic foot problems can be done through metabolic control and foot exercises. The purpose of this study was to determine the effect of diabetes foot spa measures on blood glucose levels, foot sensitivity and the ankle brachial index.Methods: This research was a pre-experimental design. The population totaled 170 DM patients and the sample was finalized at 30 respondents. The independent variable was diabetic foot spa, while the dependent variables were blood glucose levels, blood sensitivity and the ankle brachial index. The data was analyzed using a t-test and Wilcoxon rank test.Results: Diabetic foot spa in early neuropathy detection testing has a blood glucose level of t=9.523 and a p value=0.000. Diabetic foot spa also significantly affects foot sensitivity with a ρ <α (0.001<0.05) and an ankle brachial index of (ABI) ρ<α (0.008 < 0.05).Conclusion: Diabetic foot spa conducted regularly and independently can reduce the level of complications in Diabetes Mellitus patients. Furthermore, the tingling and pain in the feet can be reduced or even disappear as well as preventing complications such as foot ulcers that can often become amputations.

scholarly journals Glycemic control as an important tool in the prevention of cardiovascular aging in patients with diabetes mellitus

2021 ◽  
pp. 238-244
Author(s):  
O. A. Shatskaya ◽  
I. Z. Bondarenko ◽  
S. S. Kukharenko
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular System ◽  
Diabetes Management ◽  
Vascular Complications ◽  
The Body ◽  
Self Control ◽  
Risk Of Death ◽  
Chronic Hyperglycemia ◽  
Age Related ◽  
Patients With Diabetes

In recent decades, there has been a significant increase in the incidence and prevalence of diabetes mellitus. Diabetes mellitus is characterized by the development of vascular complications leading to early disability and a decrease in the life expectancy of patients. Aging of the body inevitably leads to the occurrence of age-related diseases, including the cardiovascular system, and increases the risk of death. Metabolic and structural and functional disorders of the cardiovascular system arising in diabetes mellitus have common pathophysiological mechanisms with aging of the body. Chronic hyperglycemia can accelerate the aging process and play a decisive role in the occurrence and prognosis of cardiovascular events in patients with diabetes mellitus. Achieving target glycemic values is an important step towards preventing vascular complications in patients with diabetes mellitus. Improved models of glucometers, equipped with a number of additional functions, allow for structured self-control of glycemia, analyze the data obtained and carry out timely correction of therapy, actively involve patients in the process of diabetes management, which will significantly increase the efficiency of disease management, reduce the risk of complications in patients and improve the quality of life.

scholarly journals Studies in Bisalbuminemia: Binding Properties of the Two Albumins

Blood ◽  
1962 ◽  
Vol 20 (2) ◽  
pp. 156-164 ◽  
Author(s):  
EDWARD J. SARCIONE ◽  
C. WILLIAM AUNGST
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Serum Protein ◽  
Serum Proteins ◽  
Protein Pattern ◽  
Total Serum ◽  
Binding Properties ◽  
Normal Human ◽  
Serum Components

Abstract 1. An abnormal serum protein pattern in a patient with Wegener’s granulomatosis and five of his relatives was identified as bisalbuminemia by electrophoretic and immunochemical methods. 2. With the exception of the patient with Wegener’s syndrome, the presence of bisalbuminemia was not associated with a significant change in total serum proteins, total albumin, serum components other than albumin, or any disease. 3. Addition of I131-thyroxine to bisalbumin sera resulted in thyroxine binding by albumin B but not by albumin A. The failure of albumin A to bind added I131-thyroxine leads to speculation that, in this family, neither albumin A nor B are identical to normal human serum albumin.

Hyperbaric Oxygen Therapy and Vascular Complications in Diabetes Mellitus

Angiology ◽  
2020 ◽  
Vol 71 (10) ◽  
pp. 876-885
Author(s):  
Ivana Resanović ◽  
Božidarka Zarić ◽  
Jelena Radovanović ◽  
Emina Sudar-Milovanović ◽  
Zoran Gluvić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Vascular Complications ◽  
Elevated Pressure ◽  
Oxygen Solubility ◽  
Oxygen Balance ◽  
Patients With Diabetes ◽  
Cardioprotective Effects

Vascular complications in patients with diabetes mellitus (DM) are common. Since impaired oxygen balance in plasma plays an important role in the pathogenesis of chronic DM-associated complications, the administration of hyperbaric oxygen therapy (HBOT) has been recommended to influence development of vascular complications. Hyperbaric oxygen therapy involves inhalation of 100% oxygen under elevated pressure from 1.6 to 2.8 absolute atmospheres in hyperbaric chambers. Hyperbaric oxygen therapy increases plasma oxygen solubility, contributing to better oxygen diffusion to distant tissues and preservation of the viability of tissues reversibly damaged by atherosclerosis-induced ischemia, along with microcirculation restoration. Hyperbaric oxygen therapy exerts antiatherogenic, antioxidant, and cardioprotective effects by altering the level and composition of plasma fatty acids and also by promoting signal transduction through membranes, which are impaired by hyperglycemia and hypoxia. In addition, HBOT affects molecules involved in the regulation of nitric oxide synthesis and in that way exerts anti-inflammatory and angiogenic effects in patients with DM. In this review, we explore the recent literature related to the effects of HBOT on DM-related vascular complications.

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