THE EFFECT OF METHYLTHIOURACIL TREATMENT ON THE HISTOCHEMICALLY DEMONSTRABLE SUCCINIC DEHYDROGENASE ACTIVITY IN THE ORGANS OF THE GUINEA-PIG

1955 ◽  
Vol 18 (2) ◽  
pp. 141-147 ◽  
Author(s):  
A. N. Kuusisto ◽  
Antti Telkkä
Keyword(s):  
Guinea Pig ◽  
Dehydrogenase Activity ◽  
Succinic Dehydrogenase ◽  
Succinic Dehydrogenase Activity

scholarly journals EFFECT OF INFECTION WITH M. TUBERCULOSIS AND OF TUBERCULIN SHOCK ON THE SUCCINIC DEHYDROGENASE ACTIVITY OF GUINEA PIG TISSUES

1953 ◽  
Vol 98 (2) ◽  
pp. 99-105 ◽  
Author(s):  
S. N. Chaudhuri ◽  
Samuel P. Martin
Keyword(s):  
Enzyme Activity ◽  
Guinea Pig ◽  
Dehydrogenase Activity ◽  
Guinea Pigs ◽  
Normal Tissue ◽  
Succinic Dehydrogenase ◽  
Tissue Extract ◽  
Succinic Dehydrogenase Activity ◽  
H37rv Strain ◽  
Sublethal Doses

The kidney of guinea pigs infected with the H37Rv and BCG strains of M. tuberculosis showed a diminution in succinic dehydrogenase activity when measured by the tetrazolium technique. This effect was also seen in the liver and spleen of animals infected with the BCG strain. Sensitized animals showed similar results when given tuberculin in sublethal doses. The succinic oxidase was also low in the kidneys of animals infected with the H37Rv strain. The depressed enzyme activity of the tissues of infected animals could be restored to normal by addition of normal tissue extract or dialysate. This suggests that the alteration in tissue metabolism observed in tuberculosis may depend upon the loss of some as yet unidentified factor important for succinic dehydrogenase activity.

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