THE ACTION OF DEOXYCORTICOSTERONE ACETATE AND OF DIETARY SODIUM AND POTASSIUM ON SKELETAL MUSCLE ELECTROLYTE IN ADRENALECTOMIZED RATS

1953 ◽  
Vol 14 (3) ◽  
pp. 245-253 ◽  
Author(s):  
D. F. Cole
Keyword(s):  
Skeletal Muscle ◽  
Dietary Sodium ◽  
Deoxycorticosterone Acetate ◽  
Sodium And Potassium ◽  
Adrenalectomized Rats

Urinary kallikrein response to repeated frusemide injections in rats: Effect of adrenalectomy and deoxycorticosterone acetate treatment

1986 ◽  
Vol 71 (5) ◽  
pp. 497-503 ◽  
Author(s):  
L. F. O. Obika ◽  
M. Marin-Grez
Keyword(s):  
Urine Volume ◽  
Urinary Kallikrein ◽  
Deoxycorticosterone Acetate ◽  
Intravenous Injections ◽  
Urinary Kallikrein Excretion ◽  
Mineralocorticoid Activity ◽  
Sodium And Potassium ◽  
Adrenalectomized Rats

1. The effect of repeated intravenous injections of frusemide (0.17 mg/kg) on the urinary kallikrein excretion of normal, adrenalectomized and deoxycorticosterone acetate (D0CA)-treated adrenalectomized rats was studied. 2. Adrenalectomy decreased baseline urinary kallikrein excretion, while DOCA treatment restored it to normal. 3. Frusemide injections repeatedly increased urinary kallikrein excretion in the three groups of rats studied. Compared with control and DOCA-treated animals, adrenalectomized rats were less responsive. 4. The excretion of urinary kallikrein was positively correlated with urine volume and with the excretion of sodium and potassium in all groups. The regression lines were shifted to the left in DOCA-treated adrenalectomized rats showing that mineralocorticoids enhance the effect of frusemide on urinary kallikrein excretion. The regression lines between urinary kallikrein excretion and the measured variables in adrenalectomized rats did not differ from those of control animals. 5. We conclude that the response of urinary kallikrein to frusemide is influenced by the level of mineralocorticoid activity. The effect of frusemide on urinary kallikrein excretion does not appear to be a ‘wash-out’ of the enzyme since its influence did not subside after repeated injections.

THE ADRENOCORTICAL CONTROL OF SODIUM METABOLISM

1956 ◽  
Vol 14 (2) ◽  
pp. 171-180
Author(s):  
R. A. DALE
Keyword(s):  
Sodium Intake ◽  
Urinary Sodium ◽  
Constant Level ◽  
Dietary Sodium ◽  
Hormone Administration ◽  
Body Sodium ◽  
Lack Of Control ◽  
Sodium Metabolism ◽  
Sodium And Potassium ◽  
Adrenalectomized Rats

SUMMARY 1. The urinary sodium output in adrenalectomized rats maintained on DCA and cortisone varies closely with the intake of sodium, in spite of a constant level of hormone administration. 2. There was evidence of lack of control of body sodium and potassium at both high and low extremes of sodium intake used. 3. It is argued that the results presented are evidence of (a) extra-adrenocortical control of sodium metabolism, and (b) increased adrenocortical secretion following sudden changes in dietary sodium.

Daily dietary sodium and potassium intake in Belgium, using duplicate portion sampling

1999 ◽  
Vol 209 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Rudy Van Cauwenbergh ◽  
Peter Hendrix ◽  
H. J. Robberecht ◽  
Hendrik A. Deelstra
Keyword(s):  
Dietary Sodium ◽  
Potassium Intake ◽  
Duplicate Portion Sampling ◽  
Duplicate Portion ◽  
Sodium And Potassium

scholarly journals Association between Parent and Child Dietary Sodium and Potassium Intakes as Assessed by 24-h Urinary Excretion

Nutrients ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 191 ◽  
Author(s):  
Carrie Service ◽  
Carley Grimes ◽  
Lynn Riddell ◽  
Feng He ◽  
Karen Campbell ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Dietary Sodium ◽  
Sodium And Potassium

Dietary Sodium, Potassium, and Sodium to Potassium Ratio in Patients With Systemic Lupus Erythematosus

2022 ◽  
pp. 109980042110654
Author(s):  
María Correa-Rodríguez ◽  
Sara DelOlmo-Romero ◽  
Gabriela Pocovi-Gerardino ◽  
José-Luis Callejas-Rubio ◽  
Raquel Ríos-Fernández ◽  
...  
Keyword(s):  
Disease Activity ◽  
Sodium Intake ◽  
Dietary Sodium ◽  
Complement C3 ◽  
Systemic Lupus ◽  
Sodium Potassium ◽  
Complement C4 ◽  
Potassium Intake ◽  
Dietary Potassium ◽  
Sodium And Potassium

Purpose: The aim of this study was to investigate the association between dietary sodium, potassium, and sodium:potassium ratio and clinical disease activity parameters, damage accrual, and cardiovascular disease risk factors in a population of patients with systemic lupus erythematous (SLE). Research design and study sample: A cross-sectional study including a total of 280 patients was conducted (90.4% females; mean age 46.9 ± 12.85 years). Data collection: The SLE Disease Activity Index (SLEDAI-2K) and the SDI Damage Index were used to assess disease activity and disease-related damage, respectively. A 24-hour diet recall was used to estimate dietary intake of sodium and potassium. Results: Dietary sodium intake was significantly associated with anti-dsDNA ( β  =  −.005; 95% CI [.002 .008]; p = .001) and complement C4 level ( β  =  −.002; 95% CI [−.003, .000]; p = .039). Dietary potassium intake was also significantly associated with complement C3 level ( β  =  −.004; 95% CI [−.007, −.001]; p = .021). Multiple logistic regression models revealed a positive association between dietary sodium intake and the risk of having hsCRP > 3 ( p = .005) and an inverse association between dietary potassium intake and the risk of having hsCRP > 3 ( p = .004). Conclusions: SLE patients with higher dietary sodium and lower dietary potassium intakes had an increased risk of higher hsCRP. Dietary sodium intake was significantly associated with anti-dsDNA and complement C4 level, while dietary potassium intake was associated with complement C3 level, supporting that dietary sodium and potassium intakes might play a key role in markers related to disease activity in SLE patients.

scholarly journals Effect of Dietary Sodium and Potassium Intake on the Mobilization of Bone Lead among Middle-Aged and Older Men: The Veterans Affairs Normative Aging Study

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2750 ◽  
Author(s):  
Xin Wang ◽  
Douglas Kim ◽  
Katherine L. Tucker ◽  
Marc G. Weisskopf ◽  
David Sparrow ◽  
...  
Keyword(s):  
Veterans Affairs ◽  
Urine Samples ◽  
Dietary Sodium ◽  
Potassium Intake ◽  
Normative Aging Study ◽  
Bone Lead ◽  
Aging Study ◽  
Urinary Lead ◽  
Normative Aging ◽  
Sodium And Potassium

Bone is a major storage site as well as an endogenous source of lead in the human body. Dietary sodium and potassium intake may play a role in the mobilization of lead from bone to the circulation. We examined whether association between bone lead and urinary lead, a marker of mobilized lead in plasma, was modified by dietary intake of sodium and potassium among 318 men, aged 48–93 years, in the Veterans Affairs (VA) Normative Aging Study. Dietary sodium and potassium were assessed by flame photometry using 24-h urine samples, and a sodium-to-potassium ratio was calculated from the resulting measures. Patella and tibia bone lead concentrations were measured by K-shell-x-ray fluorescence. Urinary lead was measured by inductively coupled plasma mass spectroscopy in 24-h urine samples. Linear regression models were used to regress creatinine clearance-corrected urinary lead on bone lead, testing multiplicative interactions with tertiles of sodium, potassium, and sodium-to-potassium ratio, separately. After adjustment for age, body mass index, smoking, vitamin C intake, calcium, and total energy intake, participants in the highest tertile of sodium-to-potassium ratio showed 28.1% (95% CI: 12.5%, 45.9%) greater urinary lead per doubling increase in patella lead, whereas those in the second and lowest tertiles had 13.8% (95% CI: −1.7%, 31.7%) and 5.5% (95% CI: −8.0%, 21.0%) greater urinary lead, respectively (p-for-interaction = 0.04). No statistically significant effect modification by either sodium or potassium intake alone was observed. These findings suggest that relatively high intake of sodium relative to potassium may play an important role in the mobilization of lead from bone into the circulation.

P1690Lab-on-a-chip based self-monitoring device for dietary intake of potassium and sodium: the LAB-CHIPS study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A C Vendeville ◽  
H A H Kaasjager ◽  
R E A Musson ◽  
W Spiering
Keyword(s):  
Lifestyle Modification ◽  
Sodium Intake ◽  
Lab On A Chip ◽  
Dietary Sodium ◽  
Monitoring Device ◽  
Self Monitoring ◽  
Potassium Intake ◽  
Self Test ◽  
Sodium And Potassium ◽  
Kawasaki Formula

Abstract Background Dietary sodium restriction and upholding adequate potassium intake is an important lifestyle modification strategy advocated in guidelines for the management of hypertension and for lowering cardiovascular risk in the general population. The gold standard for estimating sodium and potassium intake, 24-hour urine collection (24hUc), is time consuming and cumbersome, but most importantly not a good indicator of dietary habit due to day-to-day variation. New lab-on-a-chip technology has been developed to measure urinary sodium, potassium and creatinine excretion in a single drop of urine using microcapillary electrophoreses combined with conductivity analyses. Self-monitoring can be done at home over a longer period of time. Results are readily available. Purpose To assess agreement between 24hUc and the lab-on-a-chip self-monitoring device for estimating past 24h dietary sodium and potassium intake for single and multiple self-tests by using the Kawasaki, INTERSALT and Tanaka formulae. Methods Healthy participants (n=12) were asked to adhere to three different weekly dietary sodium restriction goals. Participants received verbal and written information to aim between 3.3 and 5.0 grams of sodium intake a day during week 1 (“normal”), >3.3<5.0 grams in week 2 (low) and >5.0 grams during week 3 (high). Weekly measurement instructions consisted of one self-test on day 1 through 6 and multiple self-tests (n=3) combined with a 24hUc on day 7. To estimate 24h sodium and potassium intake, Kawasaki, INTERSALT and Tanaka formulas were used. The Bland-Altman method was used to calculate the agreement. Results The agreement (mg/day) for sodium between 24hUc and a self-test on first morning urine (fmu) (Kawasaki), was −102±804 (normal), −860±592 (low) and 340±1406 (high). For multiple self-tests (n=3) performed on 24hUc days, using the INTERSALT formula, the agreement was: 577±832 (normal), −701±721 (low) and 1788±911 (high). Any combination of same day single or multiple INTERSALT or Tanaka self-tests and fmu Kawasaki did not result in better agreement. For potassium the agreement between 24hUc and fmu (Kawaksaki) was 1071±966 (normal), 1376±678 (low) and 1654±880 (high). Using the Tanaka formula resulted in further underestimation and thus worse agreement for same day self-tests and fmu. Conclusion In this study, agreement between 24hUc and the lab-on-a-chip self-monitoring device for estimating past 24h dietary sodium intake was best for a fmu self-test calculated with the Kawasaki formula. For estimating potassium intake, a fmu self-test with help of the Kawasaki formula overestimated potassium intake considerably. This lab-on-a-chip self-monitoring device has the potential to improve current lifestyle modification strategies.

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