scholarly journals Effects of Aging on Frontal White Matter Microstructure in Alcohol Use Disorder and Associations With Processing Speed

2015 ◽  
Vol 76 (2) ◽  
pp. 296-306 ◽  
Author(s):  
Scott F. Sorg ◽  
Lindsay M. Squeglia ◽  
Michael J. Taylor ◽  
Omar M. Alhassoon ◽  
Lisa M. Delano-Wood ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Processing Speed ◽  
Alcohol Use Disorder ◽  
White Matter Microstructure ◽  
Frontal White Matter ◽  
Effects Of Aging

scholarly journals Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder

2018 ◽  
Vol 42 (5) ◽  
pp. 889-896 ◽  
Author(s):  
Evgeny J. Chumin ◽  
Joaquín Goñi ◽  
Meredith E. Halcomb ◽  
Timothy C. Durazzo ◽  
Mario Dzemidzic ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
White Matter Microstructure

scholarly journals Microstructural damage of white-matter tracts connecting large-scale networks is related to impaired executive profile in alcohol use disorder

2020 ◽  
Vol 25 ◽  
pp. 102141 ◽  
Author(s):  
Chiara Crespi ◽  
Caterina Galandra ◽  
Nicola Canessa ◽  
Marina Manera ◽  
Paolo Poggi ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Large Scale ◽  
White Matter Tracts ◽  
Microstructural Damage ◽  
Large Scale Networks

scholarly journals Longitudinal processing speed impairments in males with autism and the effects of white matter microstructure

2014 ◽  
Vol 53 ◽  
pp. 137-145 ◽  
Author(s):  
Brittany G. Travers ◽  
Erin D. Bigler ◽  
Do P.M. Tromp ◽  
Nagesh Adluru ◽  
Alyson L. Froehlich ◽  
...  
Keyword(s):  
White Matter ◽  
Processing Speed ◽  
White Matter Microstructure

scholarly journals Superficial white matter microstructure affects processing speed in cerebral small vessel disease

2022 ◽  
Author(s):  
Shuyue Wang ◽  
Fan Zhang ◽  
Peiyu Huang ◽  
Hui Hong ◽  
Yeerfan Jiaerken ◽  
...  
Keyword(s):  
White Matter ◽  
Processing Speed ◽  
Diffusion Mri ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Large Contribution ◽  
Vessel Disease ◽  
White Matter Microstructure ◽  
Patient Subgroups

White matter hyperintensities (WMH) are a typical feature of cerebral small vessel disease (CSVD). This condition contributes to about 50% of dementias worldwide, a massive health burden in aging. Microstructural alterations in the deep white matter (DWM) have been widely examined in CSVD. However, little is known about abnormalities in the superficial white matter (SWM) and their relevance for processing speed, the main cognitive deficit in CSVD. In this paper, 141 patients with CSVD were studied. Processing speed was assessed by the completion time of the Trail Making Test Part A. White matter abnormalities were assessed by WMH burden (lesion volume on T2-FLAIR) and diffusion MRI, including DTI and free-water (FW) imaging microstructure measures. The results of our study indicate that the superficial white matter may play a particularly important role in cognitive decline in CSVD. SWM imaging measures resulted in a large contribution to processing speed, despite a relatively small WMH burden in the SWM. SWM FW had the strongest association with processing speed among all imaging markers and, unlike the other diffusion MRI measures, significantly increased between two patient subgroups with the lowest WMH burdens (possibly representing early stages of disease). When comparing two patient subgroups with the highest WMH burdens, the involvement of WMH in the SWM was accompanied by significant differences in processing speed and white matter microstructure. Given significant effects of WMH volume and regional FW on processing speed, we performed a mediation analysis. SWM FW was found to fully mediate the association between WMH volume and processing speed, while no mediation effect of DWM FW was observed. Overall, our findings identify SWM abnormalities in CSVD and suggest that the SWM has an important contribution to processing speed. Results indicate that FW in the SWM is a sensitive marker of microstructural changes associated with cognition in CSVD. This study extends the current understanding of CSVD-related dysfunction and suggests that the SWM, as an understudied region, can be a potential target for monitoring pathophysiological processes in future research.

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