scholarly journals Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

2016 ◽  
Vol 9 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Sharmila Hussain ◽  
Ramasamy Tamizhselvi ◽  
Leema George ◽  
Venkatraman Manickam
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteoblast Differentiation ◽  
Morinda Citrifolia ◽  
Isolated Rat ◽  
Rat Bone

Role of 5-azacytidine in the differentiation of rat bone marrow mesenchymal stem cells into cardiomyogenic cells

2012 ◽  
Vol 35 (1) ◽  
pp. 23-33
Author(s):  
Samy Hosny Hammed ◽  
Amany Mohamed El Shawarby ◽  
Mohamed Abd Elrahman Ahmed ◽  
Mohamed Kamel Abo Golayel ◽  
Asmaa Abd Elmonem Mohamed
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

scholarly journals A critical role of the K Ca 3.1 channel in mechanical stretch‐induced proliferation of rat bone marrow‐derived mesenchymal stem cells

2020 ◽  
Vol 24 (6) ◽  
pp. 3739-3744
Author(s):  
Xiaoling Jia ◽  
Hao Su ◽  
Xinlan Chen ◽  
Yangbi Huang ◽  
Yufan Zheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Critical Role ◽  
Mechanical Stretch ◽  
Rat Bone

scholarly journals Role of microRNA-335 carried by bone marrow mesenchymal stem cells-derived extracellular vesicles in bone fracture recovery

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Haifeng Hu ◽  
Dong Wang ◽  
Lihong Li ◽  
Haiyang Yin ◽  
Guoyu He ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Extracellular Vesicles ◽  
Bone Fracture ◽  
Osteoblast Differentiation ◽  
Healing Time ◽  
Marrow Mesenchymal Stem Cells ◽  
Fracture Models

AbstractMesenchymal stem cells (MSCs) have the potential to reduce healing time and treat nonunion in fracture patients. In this study, bone marrow MSCs-derived extracellular vesicles (B-EVs) were firstly extracted and identified. CD9−/− and normal mice were enrolled for the establishment of fracture models and then injected with B-EVs. Osteoblast differentiation and fracture recovery were estimated. The levels of osteoblast-related genes were detected, and differentially expressed microRNAs (miRs) in B-EVs-treated normal fracture mice were screened and verified. The downstream mechanisms of miR were predicted and assessed. The loss-of functions of miR-335 in B-EV and gain-of-functions of VapB were performed in animal and cell experiments to evaluate their roles in bone fracture. Collectively, B-EVs promoted bone fracture recovery and osteoblast differentiation by releasing miR-335. miR-335 downregulation in B-EVs impaired B-EV functions in fracture recovery and osteoblast differentiation. miR-335 could target VapB, and VapB overexpression reversed the effects of B-EVs on osteoblast differentiation. B-EV treatment activated the Wnt/β-catenin pathway in fracture mice and osteoblasts-like cells. Taken together, the study suggested that B-EVs carry miR-335 to promote bone fracture recovery via VapB and the Wnt/β-catenin pathway. This study may offer insights into bone fracture treatment.

Investigating the effect of lead acetate on rat bone marrow-derived mesenchymal stem cells toxicity: Role of apoptosis

2011 ◽  
Vol 21 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Ali M. Sharifi ◽  
Roshanak Ghazanfari ◽  
Neda Tekiyehmaroof ◽  
Mohammad A. Sharifi
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lead Acetate ◽  
Rat Bone

Role of subnano-, nano- and submicron-surface features on osteoblast differentiation of bone marrow mesenchymal stem cells

Biomaterials ◽  
2012 ◽  
Vol 33 (26) ◽  
pp. 5997-6007 ◽  
Author(s):  
Dongwoo Khang ◽  
Jungil Choi ◽  
Yeon-Min Im ◽  
Youn-Jeong Kim ◽  
Je-Hee Jang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteoblast Differentiation ◽  
Surface Features ◽  
Marrow Mesenchymal Stem Cells

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis

2018 ◽  
Vol 18 ◽  
Author(s):  
Chaitra Venugopal ◽  
Christopher Shamir ◽  
Sivapriya Senthilkumar ◽  
Janitri Venkatachala Babu ◽  
Peedikayil Kurien Sonu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neuroprotective Effects ◽  
Marrow Mesenchymal Stem Cells ◽  
Vitro Analysis ◽  
In Vitro Analysis ◽  
Rat Bone
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