PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.

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EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX

Progress on Chemistry and application of Chitin and its Derivatives ◽

10.15259/pcacd.26.015 ◽

2021 ◽

Vol 26 ◽

pp. 170-177

Author(s):

Katarzyna Małolepsza-Jarmołowska ◽

Keyword(s):

Lactic Acid ◽

Rheological Properties ◽

Sodium Alginate ◽

Contact Time ◽

Experimental Studies ◽

Vaginal Mucosa

An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.

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Voltammetric pH Measurements in Unadulterated Foodstuffs, Urine, and Serum with 3D-Printed Graphene/poly(lactic Acid) Electrodes

10.26434/chemrxiv.12698462 ◽

2020 ◽

Author(s):

Fakher M. Rabboh ◽

Glen O'Neil

Keyword(s):

Lactic Acid ◽

Excellent Agreement ◽

Alkali Metals ◽

Reaction Rates ◽

Poly Lactic Acid ◽

Ph Measurements ◽

Wide Range ◽

3D Printed ◽

Glass Ph Electrode ◽

The Impact

The pH of a system is a critical descriptor of its chemistry – impacting reaction rates, solubility, chemical speciation, and homeostasis. As a result, pH is one of the most commonly measured parameters in food safety, clinical, and environmental laboratories. Glass pH probes are the gold standard for pH measurements, but suffer drawbacks including frequent recalibration, wet storage of the glass membrane, difficulty in miniaturization, and interferences from alkali metals. In this work, we describe a voltammetric pH sensor that uses a 3D-printed graphene/poly(lactic acid) filament electrode that is pretreated to introduce quinone functional groups to the graphene surface. After thoroughly characterizing the pretreatment parameters using outer-sphere and inner-sphere redox couples, we measured pH by reducing the surface-bound quinones, which undergo a pH-dependent 2e–/2H+ reduction. The position of the redox peak was found to shift –60 ± 2 mV pH-1 at 25 ºC, which is in excellent agreement with the theoretical value predicted by the Nernst Equation (–59.2 mV pH-1). Importantly, the sensors did not require the removal of dissolved oxygen prior to successful pH measurements. We investigated the impact of common interfering species (Pb2+ and Cu2+) and found that there was no impact on the measured pH. We subsequently challenged the sensors to measure the pH of unadulterated complex samples including cola, vinegar, serum, and urine, and obtained excellent agreement compared to a glass pH electrode. In addition to the positive analytical characteristics, the sensors are extremely cheap and easy to fabricate, making them highly accessible to a wide range of researchers. These results pave the way for customizable pH sensors that can be fabricated in (nearly) any geometry for targeted applications using 3D-printing.

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Biomechanical and Physiological Conditions Influence Erythrocytes - Erythrocyte Adhesion. An in vitro Study

Applied Physics Research ◽

10.5539/apr.v9n4p23 ◽

2017 ◽

Vol 9 (4) ◽

pp. 23

Author(s):

Mohamed A. Elblbesy

Keyword(s):

Particle Diameter ◽

In Vitro Study ◽

Work Of Adhesion ◽

Physiological Conditions ◽

Erythrocyte Adhesion ◽

Inverted Microscope ◽

Erythrocyte Deformation ◽

The Impact ◽

Simple Flow

Erythrocyte - erythrocyte adhesion (EEA) is of the large interest since it will effect directly on its function and interaction with other organs. Also, erythrocytes adhesion may arise erythrocytes aggregation which has a significant effect on the hemodynamic mechanism. The present study is aimed at examining the effect of erythrocytes mechanical properties on their adhesion. In addition, the impact of the physiological conditions around erythrocytes on their adhesion will be evaluated. A simple flow compartment technique built on inverted microscope was used to calculate adhesion number (AN) of erythrocytes which reflects the ability of erythrocytes to adhere to each other. AN was correlated strongly to shear rate and erythrocyte deformation index. Shape parameters of erythrocytes (Radius and volume) were found to play a major role in EEA. The concentration of the main plasma proteins (fibrinogen and albumin) were determined to have a significant effect on EEA. The results obtained in this study give the attention that other factors rather than particle diameter and work of adhesion may effect on erythrocytes adhesion.

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Voltammetric pH Measurements in Unadulterated Foodstuffs, Urine, and Serum with 3D-Printed Graphene/poly(lactic Acid) Electrodes

10.26434/chemrxiv.12698462.v1 ◽

2020 ◽

Author(s):

Fakher M. Rabboh ◽

Glen O'Neil

Keyword(s):

Lactic Acid ◽

Excellent Agreement ◽

Alkali Metals ◽

Reaction Rates ◽

Poly Lactic Acid ◽

Ph Measurements ◽

Wide Range ◽

3D Printed ◽

Glass Ph Electrode ◽

The Impact

The pH of a system is a critical descriptor of its chemistry – impacting reaction rates, solubility, chemical speciation, and homeostasis. As a result, pH is one of the most commonly measured parameters in food safety, clinical, and environmental laboratories. Glass pH probes are the gold standard for pH measurements, but suffer drawbacks including frequent recalibration, wet storage of the glass membrane, difficulty in miniaturization, and interferences from alkali metals. In this work, we describe a voltammetric pH sensor that uses a 3D-printed graphene/poly(lactic acid) filament electrode that is pretreated to introduce quinone functional groups to the graphene surface. After thoroughly characterizing the pretreatment parameters using outer-sphere and inner-sphere redox couples, we measured pH by reducing the surface-bound quinones, which undergo a pH-dependent 2e–/2H+ reduction. The position of the redox peak was found to shift –60 ± 2 mV pH-1 at 25 ºC, which is in excellent agreement with the theoretical value predicted by the Nernst Equation (–59.2 mV pH-1). Importantly, the sensors did not require the removal of dissolved oxygen prior to successful pH measurements. We investigated the impact of common interfering species (Pb2+ and Cu2+) and found that there was no impact on the measured pH. We subsequently challenged the sensors to measure the pH of unadulterated complex samples including cola, vinegar, serum, and urine, and obtained excellent agreement compared to a glass pH electrode. In addition to the positive analytical characteristics, the sensors are extremely cheap and easy to fabricate, making them highly accessible to a wide range of researchers. These results pave the way for customizable pH sensors that can be fabricated in (nearly) any geometry for targeted applications using 3D-printing.

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RESEARCH OF HYDROPHILIC GLOBULES CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

Progress on Chemistry and application of Chitin and its Derivatives ◽

10.15259/pcacd.25.011 ◽

2020 ◽

Vol XXV ◽

pp. 143-150

Author(s):

Katarzyna Małolepsza-Jarmołowska

Keyword(s):

Lactic Acid ◽

Vaginal Mucosa ◽

Scientific Journals ◽

Natural Conditions ◽

Health Organizations ◽

Wide Range ◽

Optimum Formulation ◽

Pharmaceutical Properties ◽

Positive Results ◽

Selection Of

Gynecological scientific journals report that traditional therapeutic regimens used to treat vaginal inflammation recommended by global treatment centers and health organizations are not producing satisfactory results. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. The conducted research and obtained positive results encourage further research possibilities in the field of optimization of pharmaceutical properties of the examined gynecological preparations. Assuming the above assumptions tested impact of polyvinylpyrrolidone K-15, polyvinylpyrrolidone K-30 and polyvinylpyrrolidone K-90 in the properties of the globules. The study was prepared formulations with different pH and rheological properties. The device simulating the conditions in the vagina, studied the adhesion and movement of the gel on the mucosa of the organ. Globules after application of the apparatus simulates the natural conditions in the gel passes and cover the surface. A wide range of pH of the gels allows the selection of the optimum formulation

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THE IMPACT OF LEADERSHIP PRACTICES TO TEAM MEMBERS’ SATISFACTION

Journal of Management and Business ◽

10.24123/jmb.v8i1.132 ◽

2009 ◽

Vol 8 (1) ◽

Author(s):

Chalimah .

Keyword(s):

Conflict Resolution ◽

Leadership Practices ◽

Hotel Industry ◽

Leader Behavior ◽

Team Leader ◽

Shop Floor ◽

Team Members ◽

Top Executives ◽

Wide Range ◽

The Impact

eamwork is becoming increasingly important to wide range of operations. It applies to all levels of the company. It is just as important for top executives as it is to middle management, supervisors and shop floor workers. Poor teamwork at any level or between levels can seriously damage organizational effectiveness. The focus of this paper was therefore to examine whether leadership practices consist of team leader behavior, conflict resolution style and openness in communication significantly influenced the team member’s satisfaction in hotel industry. Result indicates that team leader behavior and the conflict resolution style significantly influenced team member satisfaction. It was surprising that openness in communication did not affect significantly to the team members’ satisfaction.

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Stress, anxiety, depression and burnout in frontline health care workers during COVID-19 pandemic: a brief systematic review and new data from Russia

10.31234/osf.io/je3ch ◽

2021 ◽

Author(s):

Ekaterina Mosolova ◽

Dmitry Sosin ◽

Sergey Mosolov

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Female Gender ◽

Assessment Tools ◽

Care Workers ◽

Younger Age ◽

Wide Range ◽

Associated Risk Factors ◽

Anxiety Depression ◽

The Impact

During the COVID-19 pandemic, healthcare workers (HCWs) have been subject to increased workload while also exposed to many psychosocial stressors. In a systematic review we analyze the impact that the pandemic has had on HCWs mental state and associated risk factors. Most studies reported high levels of depression and anxiety among HCWs worldwide, however, due to a wide range of assessment tools, cut-off scores, and number of frontline participants in the studies, results were difficult to compare. Our study is based on two online surveys of 2195 HCWs from different regions of Russia during spring and autumn epidemic outbreaks revealed the rates of anxiety, stress, depression, emotional exhaustion and depersonalization and perceived stress as 32.3%, 31.1%, 45.5%, 74.2%, 37.7% ,67.8%, respectively. Moreover, 2.4% of HCWs reported suicidal thoughts. The most common risk factors include: female gender, nurse as an occupation, younger age, working for over 6 months, chronic diseases, smoking, high working demands, lack of personal protective equipment, low salary, lack of social support, isolation from families, the fear of relatives getting infected. These results demonstrate the need for urgent supportive programs for HCWs fighting COVID-19 that fall into higher risk factors groups.

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A MODELING SYSTEM FOR CLIMATE CHANGE RISK ASSESSMENT, MANAGEMENT AND HEDGING IN COASTAL AREAS

Proceedings of International Conference "Managinag risks to coastal regions and communities in a changinag world" (EMECS'11 - SeaCoasts XXVI) ◽

10.31519/conferencearticle_5b1b9398d1adf1.08545898 ◽

2017 ◽

Author(s):

Sergei Soldatenko ◽

Genrikh Alekseev ◽

Alexander Danilov ◽

...

Keyword(s):

Climate Change ◽

Risk Assessment ◽

Coastal Areas ◽

Mitigation Strategies ◽

System Structure ◽

The Arctic ◽

Risk Modeling ◽

Wide Range ◽

Adverse Weather ◽

The Impact

Every aspect of human operations faces a wide range of risks, some of which can cause serious consequences. By the start of 21st century, mankind has recognized a new class of risks posed by climate change. It is obvious, that the global climate is changing, and will continue to change, in ways that affect the planning and day to day operations of businesses, government agencies and other organizations and institutions. The manifestations of climate change include but not limited to rising sea levels, increasing temperature, flooding, melting polar sea ice, adverse weather events (e.g. heatwaves, drought, and storms) and a rise in related problems (e.g. health and environmental). Assessing and managing climate risks represent one of the most challenging issues of today and for the future. The purpose of the risk modeling system discussed in this paper is to provide a framework and methodology to quantify risks caused by climate change, to facilitate estimates of the impact of climate change on various spheres of human activities and to compare eventual adaptation and risk mitigation strategies. The system integrates both physical climate system and economic models together with knowledge-based subsystem, which can help support proactive risk management. System structure and its main components are considered. Special attention is paid to climate risk assessment, management and hedging in the Arctic coastal areas.

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Воздействиеультразвуковогополянадинамическуювязкостьводы

Vodosnabzhenie i sanitarnaia tehnika ◽

10.35776/mnp.2019.09.04 ◽

2019 ◽

pp. 27-29

Author(s):

P. Vikulin ◽

K. Khlopov ◽

M. Cherkashin

Keyword(s):

Dynamic Viscosity ◽

Experimental Studies ◽

Ultrasonic Field ◽

Maximum Effect ◽

Ultrasonic Frequency ◽

Ultrasonic Vibrations ◽

Wastewater Disposal ◽

Laboratory Setup ◽

Sonic Treatment ◽

The Impact

Enhancing water purification processes is provided by various methods including physical ones, in particular, exposure to ultrasonic vibrations. The change in the dynamic viscosity of water affects the rate of deposition of particles in the aquatic environment which can be used in natural and wastewater treatment. At the Department Water Supply and Wastewater Disposal of the National Research Moscow State University of Civil Engineering experimental studies were conducted under laboratory conditions to study the effect of ultrasound on the change in the dynamic viscosity of water. A laboratory setup has been designed consisting of an ultrasonic frequency generator of the relative intensity, a transducer (concentrator) that transmits ultrasonic vibrations to the source water, and sonic treatment tanks. Experimental studies on the impact of the ultrasonic field in the cavitation mode on the dynamic viscosity of the aqueous medium were carried out the exposure time was obtained to achieve the maximum effect.Интенсификация процессов очистки воды осуществляется с помощью различных методов, в том числе и физических, в частности воздействием ультразвуковых колебаний. Изменение динамической вязкости воды влияет на скорость осаждения частиц в водной среде, что может быть использовано в процессах очистки природных и сточных вод. На кафедре Водоснабжение и водоотведение Национального исследовательского Московского государственного строительного университета в лабораторных условиях проведены экспериментальные исследования по изучению влияния ультразвука на изменение динамической вязкости воды. Разработана схема лабораторной установки, состоящая из генератора ультразвуковых частот с соответствующей интенсивностью, преобразователя (концентратора), передающего ультразвуковые колебания в исходную воду, и емкости для озвучивания. Выполнены экспериментальные исследования по влиянию ультразвукового поля в режиме кавитации на динамическую вязкость водной среды, получено время экспозиции для достижения максимального эффекта.

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