A Comprehensive Study and Optimization of Magnetic Nanoparticle Drug Delivery to Cancerous Tissues via External Magnetic Field

2019 ◽  
Vol 47 (2) ◽  
pp. 20180450 ◽  
Author(s):  
Reza Roohi ◽  
Homayoun Emdad ◽  
Khosrow Jafarpur
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Magnetic Nanoparticle ◽  
Nanoparticle Drug Delivery ◽  
Comprehensive Study

scholarly journals Magnetic micropump embedded in contact lens for on-demand drug delivery

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Wang ◽  
Jungyul Park
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Drug Release ◽  
Contact Lens ◽  
Tear Film ◽  
Check Valve ◽  
Drug Diffusion ◽  
On Demand ◽  
The Magnetic Field

AbstractIn this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized.

Numerical simulation of magnetic nanoparticle-based drug delivery in presence of atherosclerotic plaques and under the effects of magnetic field

2020 ◽  
Vol 366 ◽  
pp. 164-174
Author(s):  
Mostafa Varmazyar ◽  
MohammadReza Habibi ◽  
Meysam Amini ◽  
Ahmad Hajatzadeh Pordanjani ◽  
Masoud Afrand ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Numerical Simulation ◽  
Drug Delivery ◽  
Magnetic Nanoparticle ◽  
Atherosclerotic Plaques

scholarly journals Magnetic nanoparticle drug delivery systems for targeting tumor

2013 ◽  
Vol 4 (4) ◽  
pp. 385-392 ◽  
Author(s):  
Vicky V. Mody ◽  
Arthur Cox ◽  
Samit Shah ◽  
Ajay Singh ◽  
Wesley Bevins ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Magnetic Nanoparticle ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Performance Evaluation of a Magnetically Driven Microrobot for Targeted Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1210
Author(s):  
Zhuocong Cai ◽  
Qiang Fu ◽  
Songyuan Zhang ◽  
Chunliu Fan ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Fixed Point ◽  
External Magnetic Field ◽  
Targeted Drug Delivery ◽  
Drug Application ◽  
Whole Process ◽  
Computational Fluid Dynamics Cfd ◽  
Targeted Drug ◽  
Motion Characteristics

Given that the current microrobot cannot achieve fixed-point and quantitative drug application in the gastrointestinal (GI) tract, a targeted drug delivery microrobot is proposed, and its principle and characteristics are studied. Through the control of an external magnetic field, it can actively move to the affected area to realize the targeted drug delivery function. The microrobot has a cam structure connected with a radially magnetized permanent magnet, which can realize two movement modes: movement and targeted drug delivery. Firstly, the magnetic actuated capsule microrobotic system (MACMS) is analyzed. Secondly, the dynamic model and quantitative drug delivery model of the targeted drug delivery microrobot driven by the spiral jet structure are established, and the motion characteristics of the targeted drug delivery microrobot are simulated and analyzed by the method of Computational Fluid Dynamics (CFD). Finally, the whole process of the targeted drug delivery task of the microrobot is simulated. The results show that the targeted drug delivery microrobot can realize basic movements such as forward, backward, fixed-point parking and drug delivery through external magnetic field control, which lays the foundation for gastrointestinal diagnosis and treatment.

scholarly journals Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4259
Author(s):  
Sayan Ganguly ◽  
Shlomo Margel
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticle ◽  
Smart Devices ◽  
Polymeric Systems ◽  
Shape Morphing ◽  
Anti Cancer ◽  
Field Static ◽  
External Stimuli ◽  
Physical And Chemical

Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

Dynamics of ferrofluid drop deformations under spatially uniform magnetic fields

2016 ◽  
Vol 802 ◽  
pp. 245-262 ◽  
Author(s):  
P. Rowghanian ◽  
C. D. Meinhart ◽  
O. Campàs
Keyword(s):  
Magnetic Field ◽  
External Magnetic Field ◽  
Viscous Fluid ◽  
Drop Deformation ◽  
Drop Dynamics ◽  
Numerical Factor ◽  
Ellipsoidal Shape ◽  
Uniform External Magnetic Field ◽  
Exact Shape ◽  
Comprehensive Study

We systematically study the shape and dynamics of a Newtonian ferrofluid drop immersed in an immiscible, Newtonian and non-magnetic viscous fluid under the action of a uniform external magnetic field. We obtain the exact equilibrium drop shapes for arbitrary ferrofluids, characterize the extent of deviations of the exact shape from the commonly assumed ellipsoidal shape, and analyse the smoothness of highly curved tips in elongated drops. We also present a comprehensive study of drop deformation for a Langevin ferrofluid. Using a computational scheme that allows fast and accurate simulations of ferrofluid drop dynamics, we show that the dynamics of drop deformation by an applied magnetic field is described up to a numerical factor by the same time scale as drop relaxation in the absence of any magnetic field. The numerical factor depends on the ratio of viscosities and the ratio of magnetic to capillary stresses, but is independent of the nature of the ferrofluid in most practical cases.

scholarly journals Preparation of Magnetic Hybrid Microspheres with Well-Defined Yolk-Shell Structure

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Yuan Zhao ◽  
Tao Chen ◽  
Shaofa Sun ◽  
Long Zhao
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Magnetic Particles ◽  
Suspension Polymerization ◽  
Magnetic Microspheres ◽  
Vibrating Sample Magnetometry ◽  
Efficient Route ◽  
Magnetic Bioseparation ◽  
Tga Analysis

A facile and efficient route was reported to prepare a kind of yolk-shell magnetic hybrid microspheres by suspension polymerization and calcinations method. The morphology, structure, and composition of the magnetic microspheres were characterized by FTIR, XRD, TEM, SEM, and TGA analysis. The vibrating-sample magnetometry (VSM) results clearly showed that the magnetic particles were superparamagnetic with saturation magnetization of 32.82 emu/g which makes the microcomposites easily controlled by an external magnetic field. The results revealed that the magnetic hybrid microspheres might have important applications in magnetic bioseparation and drug delivery.

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