A Novel Fluorescent Quadruplex STR Typing System and the Allele Frequency Distributions in a Thai Population

2003 ◽  
Vol 48 (1) ◽  
pp. 2002006 ◽  
Author(s):  
Takashi Yoshimoto ◽  
Toshimichi Yamamoto ◽  
Masaki Mizutani ◽  
Rieko Uchihi ◽  
Hiroyuki Ohtaki ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Str Typing ◽  
Thai Population ◽  
Frequency Distributions ◽  
Typing System

scholarly journals Association between EFHD2 gene polymorphisms and schizophrenia among the Han population in northern China

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052093280
Author(s):  
Meng Gao ◽  
Kuo Zeng ◽  
Ya Li ◽  
Yong-ping Liu ◽  
Xi Xia ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Neurodevelopmental Disorder ◽  
Haplotype Frequency ◽  
Northern China ◽  
Polymorphism Analysis ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Gene Encoding ◽  
Frequency Distributions ◽  
And Control

Objective Schizophrenia is a severe neurodevelopmental disorder with a complex genetic and environmental etiology. The gene encoding EF-hand domain-containing protein D2 ( EFHD2) may be a genetic risk locus for schizophrenia. Methods We genotyped four EFHD2 single-nucleotide polymorphisms (281 schizophrenia cases [SCZ], 321 controls) from northern Chinese Han individuals using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism analysis. Differences existed in genotype, allele, and haplotype frequency distributions between SCZ and control groups. Results The rs2473357 genotype and allele frequency distributions differed between SCZ and controls; however, this difference disappeared after Bonferroni correction. Differences in rs2473357 genotype and allele frequency distributions between SCZ and controls were more pronounced in men than in women. The G allele increased schizophrenia risk (odds ratio = 1.807, 95% confidence interval = 1.164–2.803). Among six haplotypes (G–, A–, G-insC, A-C, G-C, and G-T), the G– haplotype frequency distribution differed between SCZ and controls in women; the A-C and G-C haplotype frequency distributions differed between SCZ and controls in men. Conclusions EFHD2 may be involved in schizophrenia. Sex differences in EFHD2 genotype and allele frequency distributions existed among schizophrenia patients. Further research is needed to determine the role of EFHD2 in schizophrenia.

A novel 13‐plex STR typing system for individual identification and parentage testing of donkeys ( Equus asinus )

2019 ◽  
Vol 52 (2) ◽  
pp. 290-297 ◽  
Author(s):  
W. Dang ◽  
S. Shang ◽  
X. Zhang ◽  
Y. Yu ◽  
D. M. Irwin ◽  
...  
Keyword(s):  
Individual Identification ◽  
Str Typing ◽  
Parentage Testing ◽  
Equus Asinus ◽  
Typing System

scholarly journals X-chromosomal STR based genetic polymorphisms and demographic history of Sri Lankan ethnicities and their relationship with global populations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nandika Perera ◽  
Gayani Galhena ◽  
Gaya Ranawaka
Keyword(s):  
Allele Frequency ◽  
Demographic History ◽  
Evolutionary Genetics ◽  
Haplotype Frequency ◽  
Allele Frequency Distribution ◽  
Sri Lankan ◽  
Frequency Distributions ◽  
Autosomal Str ◽  
History Of ◽  
Multiplex System

AbstractA new 16 X-short tandem repeat (STR) multiplex PCR system has recently been developed for Sr Lankans, though its applicability in evolutionary genetics and forensic investigations has not been thoroughly assessed. In this study, 838 unrelated individuals covering all four major ethnic groups (Sinhalese, Sri Lankan Tamils, Indian Tamils and Moors) in Sri Lanka were successfully genotyped using this new multiplex system. The results indicated a high forensic efficiency for the tested loci in all four ethnicities confirming its suitability for forensic applications of Sri Lankans. Allele frequency distribution of Indian Tamils showed subtle but statistically significant differences from those of Sinhalese and Moors, in contrast to frequency distributions previously reported for autosomal STR alleles. This suggest a sex biased demographic history among Sri Lankans requiring a separate X-STR allele frequency database for Indian Tamils. Substantial differences observed in the patterns of LD among the four groups demand the use of a separate haplotype frequency databases for each individual ethnicity. When analysed together with other 14 world populations, all Sri Lankan ethnicities except Indian Tamils clustered closely with populations from Indian Bhil tribe, Bangladesh and Europe reflecting their shared Indo-Aryan ancestry.

scholarly journals Allele Frequency Distributions of the Drug Metabolizer Genes CYP2C9*2, CYP2C9*3, and CYP2C19*17 in the Buginese Population of Indonesia

2015 ◽  
Vol 12 (4) ◽  
pp. 236-239 ◽  
Author(s):  
Zullies Ikawati ◽  
Theresia Askitosari ◽  
Lukman Hakim ◽  
Joseph Tucci ◽  
John Mitchell
Keyword(s):  
Allele Frequency ◽  
Frequency Distributions

Adaptation and Natural Selection

2021 ◽  
pp. 125-154
Author(s):  
Áki J. Láruson ◽  
Floyd A. Reed
Keyword(s):  
Natural Selection ◽  
Allele Frequency ◽  
Levels Of Selection ◽  
Frequency Data ◽  
Selection Coefficient ◽  
Frequency Distributions ◽  
Single Allele ◽  
Selection Strength ◽  
The Difference ◽  
Over Time

Here non-random shifts in allele frequencies over time are introduced, as well as how to incorporate varying levels of selection into a model of a single population through time. This chapter highlights the difference between weak and strong selection, the dynamics of single allele versus genotype-level selection, and how selection strength and population size affect allele frequency distributions over time. Finally the inference of the selection coefficient from allele frequency data is discussed, alongside the concepts of overdominance and underdominance.

Allele Frequency Distributions at Three Pentanucleotide Repeat STRs in a Japanese Population

2006 ◽  
Vol 51 (1) ◽  
pp. 193-194 ◽  
Author(s):  
Hiroyuki Ohtaki ◽  
Toshimichi Yamamoto ◽  
Shogo Yoshikawa ◽  
Takashi Yoshimoto ◽  
Rieko Uchihi ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Japanese Population ◽  
Frequency Distributions ◽  
Pentanucleotide Repeat

Quadruplex fluorescent STR typing system (HUMVWA, HUMTH01, D21S11 and HPRT) with sequence-defined allelic ladders

1998 ◽  
Vol 94 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
Feng-Xia Xiao ◽  
Anja Gilissen ◽  
Jean-Jacques Cassiman ◽  
Ronny Decorte
Keyword(s):  
Str Typing ◽  
Typing System

Evolution of Pacific/Asian populations inferred from HLA class II allele frequency distributions

2000 ◽  
Vol 55 (5) ◽  
pp. 383-400 ◽  
Author(s):  
S.J. Mack ◽  
T.L. Bugawan ◽  
P.V. Moonsamy ◽  
J.A. Erlich ◽  
E.A. Trachtenberg ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Class Ii ◽  
Hla Class Ii ◽  
Frequency Distributions ◽  
Asian Populations
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