scholarly journals A Versatile Gene Delivery System for Efficient and Tumor Specific Gene Manipulation in vivo

Discoveries ◽  
2016 ◽  
Vol 4 (2) ◽  
pp. e58 ◽  
Author(s):  
Wei Wang ◽  
◽  
Bingning Dong ◽  
Michael Ittmann ◽  
Feng Yang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Specific Gene ◽  
Gene Delivery System ◽  
Gene Manipulation

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine

In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules

2019 ◽  
Vol 21 (12) ◽  
Author(s):  
Kaori Koizumi ◽  
Hitomi Nakamura ◽  
Masumi Iijima ◽  
Takashi Matsuzaki ◽  
Masaharu Somiya ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Delivery System

From single to a dual-gene delivery nanosystem: coordinated expression matters for boosting the neovascularization in vivo

2020 ◽  
Vol 8 (8) ◽  
pp. 2318-2328 ◽  
Author(s):  
Bin Gao ◽  
Xiaoyu Wang ◽  
Meiyu Wang ◽  
Xiang-kui Ren ◽  
Jintang Guo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Delivery System ◽  
Coordinated Expression

A dual-gene delivery system with coordinated expression function boosted the neovascularization.

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 342-343 ◽  
pp. 449-452 ◽  
Author(s):  
Tae Hee Kim ◽  
Hua Jin ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

Pancreatic Cancer Induced by In Vivo Electroporation-Enhanced Sleeping Beauty Transposon Gene Delivery System in Mouse

Pancreas ◽  
2014 ◽  
Vol 43 (4) ◽  
pp. 614-618 ◽  
Author(s):  
June-Shine Park ◽  
Kyung-Min Lim ◽  
Sung Goo Park ◽  
Sun Young Jung ◽  
Hyun-Ji Choi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gene Delivery ◽  
Delivery System ◽  
Sleeping Beauty ◽  
Gene Delivery System ◽  
In Vivo Electroporation ◽  
Sleeping Beauty Transposon

scholarly journals Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Negishi ◽  
Yuka Tsunoda ◽  
Yoko Endo-Takahashi ◽  
Yusuke Oda ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Imaging System ◽  
Effective Means ◽  
Gene Delivery System ◽  
Highly Efficient ◽  
Efficient Gene

Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulness of US-mediated gene transfer systems with BL into synoviocytes in vitro and joint synovium in vivo. Highly efficient gene transfer could be achieved in the cultured primary synoviocytes transfected with the combination of BL and US exposure, compared to treatment with plasmid DNA (pDNA) alone, pDNA plus BL, or pDNA plus US. When BL was injected into the knee joints of mice, and US exposure was applied transcutaneously to the injection site, highly efficient gene expression could be observed in the knee joint transfected with the combination of BL and US exposure, compared to treatment with pDNA alone, pDNA plus BL, or pDNA plus US. The localized and prolonged gene expression was also shown by an in vivo luciferase imaging system. Thus, this local gene delivery system into joint synovium using the combination of BL and US exposure may be an effective means for gene therapy in joint disorders.

scholarly journals Development of a flexible and specific gene delivery system for production of murine tumor models

Oncogene ◽  
1999 ◽  
Vol 18 (38) ◽  
pp. 5253-5260 ◽  
Author(s):  
Galen H Fisher ◽  
Sandra Orsulic ◽  
Eric Holland ◽  
Wendy P Hively ◽  
Yi Li ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Specific Gene ◽  
Gene Delivery System ◽  
Tumor Models ◽  
Murine Tumor
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