scholarly journals The relationship between phosphorus level and peak oxygen uptake in hemodialysis patients awaited for renal transplantation

2019 ◽  
Vol 9 (1) ◽  
pp. 05-05
Author(s):  
Boshra Hasanzamani ◽  
Mohammad Javad Mojahedi ◽  
Saba Khajeh Dargi ◽  
Amir Mohamad Hashem Asnaashari
Keyword(s):  
Renal Transplant ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Hemodialysis Patients ◽  
Phosphorus Level ◽  
Vo2 Max ◽  
The Mean ◽  
Transplant Candidates ◽  
The Relationship

Introduction: End-stage renal disease (ESRD) is one of the most common diseases, which affects many aspects of patients’ lives. The measurement of exercise capacity through peak oxygen uptake is an important factor in predicting mortality and survival in patients with ESRD. Objectives: In the current study, we aimed to examine the relationship between phosphorus level and VO2 uptake in renal transplant candidates receiving hemodialysis. Patients and Methods: Thirty renal transplant candidates on hemodialysis were evaluated through spirometry and exercise tests. Then, the results were compared according to the inclusion criteria of age, gender, and phosphorus level. Results: All of cases were male with the mean age of 37.93±10.48 years (range; 20-55 years). Mean VO2 max was 23.46±8.22 mL/kg/min (range; 6.88 to 43.44 mL/kg/min). The mean phosphorus level was 6±2.3 mg/dL (range; 2-10.6 mg/dL) since eight patients had high levels of phosphorus (more than 5.5 mg/dL). In patients with low phosphorus level an abnormal VO2 max was detected (P=0.027). Furthermore, Fisher’s exact test reflected a significant association between higher levels of phosphorus with normal VO2 max (P=0.029). Conclusion: In hemodialysis, decreased blood phosphorus is a predisposing factor for reduced exercise capacity, while hypophosphatemia may lower VO2 max through reducing energy of skeletal muscles. The relationship between phosphorus level and VO2 max may be related to morbidity in hemodialysis patients. Hence, treatment modalities reducing serum levels of phosphorus should be conducted with caution in some patients.

scholarly journals Does allogeneic stem cell transplantation in survivors of pediatric leukemia impact regular physical activity, pulmonary function, and exercise capacity?

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Katharina Ruf ◽  
Alaa Badran ◽  
Céline Siauw ◽  
Imme Haubitz ◽  
Paul-Gerhardt Schlegel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Stem Cell ◽  
Oxygen Uptake ◽  
Stem Cell Transplantation ◽  
Pulmonary Function ◽  
Cell Transplantation ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

scholarly journals Mismatch between self-estimated and objectively assessed exercise capacity in patients with congenital heart disease varies in regard to complexity of cardiac defects

2020 ◽  
pp. 1-7
Author(s):  
Julius M. Woile ◽  
Stefan Dirks ◽  
Friederike Danne ◽  
Felix Berger ◽  
Stanislav Ovroutski
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Congenital Heart ◽  
Cardiopulmonary Exercise Testing ◽  
Peak Oxygen Uptake ◽  
Subjective Rating ◽  
Cardiac Defects ◽  
Cardiopulmonary Exercise

Abstract Aim: Regular evaluation of physical capacity takes a crucial part in long-term follow-up in patients with congenital heart disease (CHD). This study aims to examine the accuracy of self-estimated exercise capacity compared to objective assessments by cardiopulmonary exercise testing in patients with CHD of various complexity. Methods: We conducted a single centre, cross-sectional study with retrospective analysis on 382 patients aged 8–68 years with various CHD who completed cardiopulmonary exercise tests. Peak oxygen uptake was measured. Additionally, questionnaires covering self-estimation of exercise capacity were completed. Peak oxygen uptake was compared to patient’s self-estimated exercise capacity with focus on differences between complex and non-complex defects. Results: Peak oxygen uptake was 25.5 ± 7.9 ml/minute/kg, corresponding to 75.1 ± 18.8% of age- and sex-specific reference values. Higher values of peak oxygen uptake were seen in patients with higher subjective rating of exercise capacity. However, oxygen uptake in patients rating their exercise capacity as good (mean oxygen uptake 78.5 ± 1.6%) or very good (mean oxygen uptake 84.8 ± 4.8%) was on average still reduced compared to normal. In patients with non-complex cardiac defects, we saw a significant correlation between peak oxygen uptake and self-estimated exercise capacity (spearman-rho −0.30, p < 0.001), whereas in patients with complex cardiac defects, no correlation was found (spearman-rho −0.11, p < 0.255). Conclusion: The mismatch between self-estimated and objectively assessed exercise capacity is most prominent in patients with complex CHD. Registration number at Charité Universitätsmedizin Berlin Ethics Committee: EA2/106/14.

scholarly journals Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Asterios Kampouras ◽  
Elpis Hatziagorou ◽  
Vasiliki Avramidou ◽  
Vasiliki Georgopoulou ◽  
Fotios Kirvassilis ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
High Resolution Computed Tomography ◽  
Exercise Limitation ◽  
Multiple Breath Washout ◽  
Colonization Status

Introduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects. Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results. 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p<0.001), LCI (p<0.001), as well as FEV1% (p<0.001) and FVC% (p<0.001). Pseudomonas colonization could predict VO2 peak% (p<0.001, r2: −0.395). Conclusion. Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

scholarly journals Physical exercise training in patients with a Fontan circulation: A systematic review

2020 ◽  
pp. 204748732094286
Author(s):  
Linda E Scheffers ◽  
Linda EM vd Berg ◽  
Gamida Ismailova ◽  
Karolijn Dulfer ◽  
Johanna JM Takkenberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Cardiac Function ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Training Intervention ◽  
Fontan Patients

Background Patients with a Fontan circulation have a reduced exercise capacity, which is an important prognostic predictor of morbidity and mortality. A way to increase exercise capacity in Fontan patients might be exercise training. This systematic review assesses the effects of exercise training investigated in Fontan patients in order to provide an overview of current insights. Design and methods Studies evaluating an exercise training intervention in Fontan patients published up to February 2020 were included in this systematic review. Results From 3000 potential studies, 16 studies reported in 22 publications met the inclusion criteria. In total, 264 Fontan patients with mean age range 8.7–31 years, were included. Different training types including inspiratory muscle training, resistance training and aerobic training were investigated. Main outcome measures reported were peak oxygen uptake, cardiac function, lung function, physical activity levels and quality of life. Peak oxygen uptake increased significantly in 56% of the studies after training with an overall mean increase of +1.72 ml/kg/min (+6.3%). None of the studies reported negative outcome measures related to the exercise programme. In four studies an adverse event was reported, most likely unrelated to the training intervention. Conclusions Exercise training in Fontan patients is most likely safe and has positive effects on exercise capacity, cardiac function and quality of life. Therefore exercise training in Fontan patients should be encouraged. Further studies are required to assess the optimal training type, intensity, duration and long-term effects.

Frühgeborene mit bronchopulmonaler Dysplasie: Geeignete Therapien im Kindheitsverlauf entwickeln

2020 ◽  
Vol 8 (2) ◽  
pp. 86-88
Author(s):  
David Brandt
Keyword(s):  
Physical Activity ◽  
Lung Function ◽  
Oxygen Uptake ◽  
Sedentary Behaviour ◽  
Linear Model ◽  
Exercise Capacity ◽  
General Linear Model ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
General Linear

Background: Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on longterm lung function impairments. Therefore, the objective of this study was to compare exercise capacity and habitual physical activity between children born very and extremely preterm with and without BPD and term-born children. Methods: Twenty-two school-aged children (aged 8 to 12 years) born with a gestational age < 32 weeks and a birthweight < 1500 g (9 with moderate or severe BPD (=BPD), 13 without BPD (=No-BPD)) and 15 healthy termborn children (=CONTROL) were included in the study. Physical activity was measured by accelerometry, lung function by spirometry and exercise capacity by an incremental cardiopulmonary exercise test. Results: Peak oxygen uptake was reduced in the BPD-group (83 ± 11%predicted) compared to the No-BPD group (91 ± 8%predicted) and the CONTROL group (94 ± 9%predicted). In a general linear model, variance of peak oxygen uptake was significantly explained by BPD status and height but not by prematurity (p < 0.001). Compared to CONTROL, all children born preterm spent significantly more time in sedentary behaviour (BPD 478 ± 50 min, No-BPD 450 ± 52 min, CONTROL 398 ± 56 min, p < 0.05) and less time in moderate-to-vigorous-physical activity (BPD 13 ± 8 min, No-BPD 16 ± 8 min, CONTROL 33 ± 16 min, p < 0.001). Prematurity but not BPD contributed significantly to explained variance in a general linear model of sedentary behaviour and likewise moderate-tovigorous-physical activity (p < 0.05 and p < 0.001 respectively). Conclusion: In our cohort, BPD but not prematurity was associated with a reduced exercise capacity at school-age. However, prematurity regardless of BPD was related to less engagement in physical activity and more time spent in sedentary behaviour. Thus, our findings suggest diverging effects of prematurity and BPD on exercise capacity and physical activity.

THE EFFECT OF AGING ON THE RELATIONSHIP BETWEEN BLOOD VOLUME AND PEAK OXYGEN UPTAKE

1999 ◽  
Vol 31 (Supplement) ◽  
pp. S155
Author(s):  
T. Ito ◽  
A. Takamata ◽  
T. Yoshida ◽  
T. Kawabata ◽  
M. Kimura ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Blood Volume ◽  
Peak Oxygen Uptake ◽  
The Relationship

scholarly journals Skeletal Muscle-Specific Expression of PGC-1α-b, an Exercise-Responsive Isoform, Increases Exercise Capacity and Peak Oxygen Uptake

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28290 ◽  
Author(s):  
Miki Tadaishi ◽  
Shinji Miura ◽  
Yuko Kai ◽  
Yutaka Kano ◽  
Yuichi Oishi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Specific Expression

Upper Body Exercise Capacity in Youth with Spina Bifida

1993 ◽  
Vol 10 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kenneth Coutts ◽  
Donald McKenzie ◽  
Christine Loock ◽  
Richard Beauchamp ◽  
Robert Armstrong
Keyword(s):  
Spina Bifida ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Handgrip Strength ◽  
Anaerobic Power ◽  
Total Sample ◽  
Peak Oxygen Uptake ◽  
Upper Body ◽  
Upper Body Exercise ◽  
Gender And Age

The purpose of this study was to describe the upper body exercise capabilities of youth with spina bifida, which would permit comparison of their abilities to norms. Forty-two children with spina bifida age 7 to 18 years were tested for maximal handgrip strength, anaerobic arm-crank power output, and peak arm-crank oxygen uptake. Analysis of variance was used to compare age, gender, and level of disability differences within the total sample. This analysis indicated no significant effect of level of disability on any of the upper body exercise capacity measures. Significant gender and age effects were noted for grip strength and anaerobic and aerobic capabilities. The sample exhibited handgrip strength comparable to that of nondisabled youth but low anaerobic power and peak oxygen uptake values. Some individual subjects, however, had “normal” values for all tests suggesting that a lower level of participation in regular physical activity rather than spina bifida per se may be responsible for the generally lower physical capacity found in the total sample.

scholarly journals Peak oxygen uptake and exercise capacity: a reliable predictor of quality of life?

2009 ◽  
Vol 30 (13) ◽  
pp. 1674-1674 ◽  
Author(s):  
S. Glaser ◽  
C. Schaper ◽  
R. Ewert ◽  
B. Koch
Keyword(s):  
Quality Of Life ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Reliable Predictor
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