Frühgeborene mit bronchopulmonaler Dysplasie: Geeignete Therapien im Kindheitsverlauf entwickeln

2020 ◽  
Vol 8 (2) ◽  
pp. 86-88
Author(s):  
David Brandt
Keyword(s):  
Physical Activity ◽  
Lung Function ◽  
Oxygen Uptake ◽  
Sedentary Behaviour ◽  
Linear Model ◽  
Exercise Capacity ◽  
General Linear Model ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
General Linear

Background: Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on longterm lung function impairments. Therefore, the objective of this study was to compare exercise capacity and habitual physical activity between children born very and extremely preterm with and without BPD and term-born children. Methods: Twenty-two school-aged children (aged 8 to 12 years) born with a gestational age < 32 weeks and a birthweight < 1500 g (9 with moderate or severe BPD (=BPD), 13 without BPD (=No-BPD)) and 15 healthy termborn children (=CONTROL) were included in the study. Physical activity was measured by accelerometry, lung function by spirometry and exercise capacity by an incremental cardiopulmonary exercise test. Results: Peak oxygen uptake was reduced in the BPD-group (83 ± 11%predicted) compared to the No-BPD group (91 ± 8%predicted) and the CONTROL group (94 ± 9%predicted). In a general linear model, variance of peak oxygen uptake was significantly explained by BPD status and height but not by prematurity (p < 0.001). Compared to CONTROL, all children born preterm spent significantly more time in sedentary behaviour (BPD 478 ± 50 min, No-BPD 450 ± 52 min, CONTROL 398 ± 56 min, p < 0.05) and less time in moderate-to-vigorous-physical activity (BPD 13 ± 8 min, No-BPD 16 ± 8 min, CONTROL 33 ± 16 min, p < 0.001). Prematurity but not BPD contributed significantly to explained variance in a general linear model of sedentary behaviour and likewise moderate-tovigorous-physical activity (p < 0.05 and p < 0.001 respectively). Conclusion: In our cohort, BPD but not prematurity was associated with a reduced exercise capacity at school-age. However, prematurity regardless of BPD was related to less engagement in physical activity and more time spent in sedentary behaviour. Thus, our findings suggest diverging effects of prematurity and BPD on exercise capacity and physical activity.

scholarly journals Diverging effects of premature birth and bronchopulmonary dysplasia on exercise capacity and physical activity – a case control study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Katharina Ruf ◽  
Wolfgang Thomas ◽  
Maximilian Brunner ◽  
Christian P. Speer ◽  
Helge Hebestreit
Keyword(s):  
Physical Activity ◽  
Lung Function ◽  
Oxygen Uptake ◽  
Sedentary Behaviour ◽  
Linear Model ◽  
Exercise Capacity ◽  
Bronchopulmonary Dysplasia ◽  
Vigorous Physical Activity ◽  
General Linear Model ◽  
Peak Oxygen Uptake

Abstract Background Extreme prematurity has been associated with exercise intolerance and reduced physical activity. We hypothesized that children with bronchopulmonary dysplasia (BPD) would be especially affected based on long-term lung function impairments. Therefore, the objective of this study was to compare exercise capacity and habitual physical activity between children born very and extremely preterm with and without BPD and term-born children. Methods Twenty-two school-aged children (aged 8 to 12 years) born with a gestational age < 32 weeks and a birthweight < 1500 g (9 with moderate or severe BPD (=BPD), 13 without BPD (=No-BPD)) and 15 healthy term-born children (=CONTROL) were included in the study. Physical activity was measured by accelerometry, lung function by spirometry and exercise capacity by an incremental cardiopulmonary exercise test. Results Peak oxygen uptake was reduced in the BPD-group (83 ± 11%predicted) compared to the No-BPD group (91 ± 8%predicted) and the CONTROL group (94 ± 9%predicted). In a general linear model, variance of peak oxygen uptake was significantly explained by BPD status and height but not by prematurity (p < 0.001). Compared to CONTROL, all children born preterm spent significantly more time in sedentary behaviour (BPD 478 ± 50 min, No-BPD 450 ± 52 min, CONTROL 398 ± 56 min, p < 0.05) and less time in moderate-to-vigorous-physical activity (BPD 13 ± 8 min, No-BPD 16 ± 8 min, CONTROL 33 ± 16 min, p < 0.001). Prematurity but not BPD contributed significantly to explained variance in a general linear model of sedentary behaviour and likewise moderate-to-vigorous-physical activity (p < 0.05 and p < 0.001 respectively). Conclusion In our cohort, BPD but not prematurity was associated with a reduced exercise capacity at school-age. However, prematurity regardless of BPD was related to less engagement in physical activity and more time spent in sedentary behaviour. Thus, our findings suggest diverging effects of prematurity and BPD on exercise capacity and physical activity.

scholarly journals Does allogeneic stem cell transplantation in survivors of pediatric leukemia impact regular physical activity, pulmonary function, and exercise capacity?

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Katharina Ruf ◽  
Alaa Badran ◽  
Céline Siauw ◽  
Imme Haubitz ◽  
Paul-Gerhardt Schlegel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Stem Cell ◽  
Oxygen Uptake ◽  
Stem Cell Transplantation ◽  
Pulmonary Function ◽  
Cell Transplantation ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival in high-risk childhood leukemia but is associated with long-term sequelae such as impaired pulmonary function and reduced exercise capacity impacting quality of life. Methods A convenience sample of 17 patients after allo-HSCT (HSCT—12 male, age 15.7±6.7 years, time after HSCT 5.3±2.8 years) underwent pulmonary function testing, echocardiography, and an incremental exercise test on a bike. Physical activity and health-related quality of life were assessed by questionnaires (7-day physical activity recall, PEDS-QL). Seventeen healthy age- and gender-matched controls served as control group (CG) for results of pulmonary function and exercise testing. Results HSCT showed reduced pulmonary function (HSCT vs. CG: FEV1 90.5±14.0 vs. 108.0±8.7%pred; FVC 88.4±19.3 vs. 107.6±6.9%pred, DLCO 75.3±23.6 vs. 104.9±12.8%pred) and exercise capacity (VO2peak 89±30.8%pred, CG 98±17.5%pred; Wmax 84±21.7%pred, CG 115±22.8%pred), but no relevant cardiac dysfunction and a good quality of life (PEDS-QL mean overall score 83.3±10.7). Differences in peak oxygen uptake between groups were mostly explained by 5 adolescent patients who underwent total body irradiation for conditioning. They showed significantly reduced diffusion capacity and reduced peak oxygen uptake. Patients reported a mean time of inactivity of 777±159min/day, moderate activity of 110±107 min/day, hard activity of 35±36 min/day, and very hard activity of 23±22 min/day. A higher amount of inactivity was associated with a lower peak oxygen uptake (correlation coefficient tau −0.48, p=0.023). Conclusions This pilot study shows that although patients after allo-HSCT reported a good quality of life, regular physical activity and exercise capacity are reduced in survivors of stem cell transplantation, especially in adolescents who are treated with total body irradiation for conditioning. Factors hindering regular physical activity need to be identified and exercise counseling should be part of follow-up visits in these patients.

scholarly journals Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Asterios Kampouras ◽  
Elpis Hatziagorou ◽  
Vasiliki Avramidou ◽  
Vasiliki Georgopoulou ◽  
Fotios Kirvassilis ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
High Resolution Computed Tomography ◽  
Exercise Limitation ◽  
Multiple Breath Washout ◽  
Colonization Status

Introduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects. Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results. 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p<0.001), LCI (p<0.001), as well as FEV1% (p<0.001) and FVC% (p<0.001). Pseudomonas colonization could predict VO2 peak% (p<0.001, r2: −0.395). Conclusion. Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

scholarly journals Functional impact of exercise pulmonary hypertension in patients with borderline resting pulmonary arterial pressure

2017 ◽  
Vol 7 (3) ◽  
pp. 654-665 ◽  
Author(s):  
Rudolf K. F. Oliveira ◽  
Mariana Faria-Urbina ◽  
Bradley A. Maron ◽  
Mario Santos ◽  
Aaron B. Waxman ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Oxygen Uptake ◽  
Arterial Pressure ◽  
Right Ventricular ◽  
Exercise Capacity ◽  
Pulmonary Arterial Pressure ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
Functional Impact ◽  
Pulmonary Arterial

Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study, we sought to evaluate the prevalence and functional impact of exercise pulmonary hypertension (ePH) across a spectrum of resting mPAP’s in consecutive patients with contemporary resting right heart catheterization (RHC) and invasive cardiopulmonary exercise testing. Patients with resting mPAP <25 mmHg and pulmonary arterial wedge pressure ≤15 mmHg (n = 312) were stratified by mPAP < 13, 13–16, 17–20, and 21–24 mmHg. Those with ePH (n = 35) were compared with resting precapillary pulmonary hypertension (rPH; n = 16) and to those with normal hemodynamics (non-PH; n = 224). ePH prevalence was 6%, 8%, and 27% for resting mPAP 13–16, 17–20, and 21–24 mmHg, respectively. Within each of these resting mPAP epochs, ePH negatively impacted exercise capacity compared with non-PH (peak oxygen uptake 70 ± 16% versus 92 ± 19% predicted, P < 0.01; 72 ± 13% versus 86 ± 17% predicted, P < 0.05; and 64 ± 15% versus 82 ± 19% predicted, P < 0.001, respectively). Overall, ePH and rPH had similar functional limitation (peak oxygen uptake 67 ± 15% versus 68 ± 17% predicted, P > 0.05) and similar underlying mechanisms of exercise intolerance compared with non-PH (peak oxygen delivery 1868 ± 599 mL/min versus 1756 ± 720 mL/min versus 2482 ± 875 mL/min, respectively; P < 0.05), associated with chronotropic incompetence, increased right ventricular afterload and signs of right ventricular/pulmonary vascular uncoupling. In conclusion, ePH is most frequently found in borderline mPAP, reducing exercise capacity in a manner similar to rPH. When borderline mPAP is identified at RHC, evaluation of the pulmonary circulation under the stress of exercise is warranted.

scholarly journals Analysis of the Levels of Physical Activity in the Quality of Life of Elderly Patients With Hypertension

2020 ◽  
Vol 12 (4) ◽  
pp. 138
Author(s):  
Leônidas Oliveira Neto ◽  
Vagner Deuel de Oliveira Tavares ◽  
Ângelo Augusto Paula do Nascimento ◽  
Kenio Costa Lima
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Elderly Patients ◽  
Linear Model ◽  
Mental Status ◽  
General Linear Model ◽  
General Linear

BACKGROUND: Changes in lifestyle are essential to promote the control of hypertension and quality of life in older adults. Objective: To verify the influence of the level of physical activity (LPA) on quality of life in hypertensive older adults. METHOD: The sample included a total of 291 hypertensive older adults, 102 men and 189 women, with a mean age of 69.7 &plusmn; 7.7 and 69.2 &plusmn; 7.2 respectively. The General Linear Model was applied to measure the interactions (LPA and sex) between active and inactive groups. RESULTS: There was a difference between active men and active women with inactive older adults of both sexes for mental status (p&lt;.0001), as well as a difference between active men and active women with inactive older adults of both sexes for somatic manifestations (p&lt;.0001). No differences were observed between active men and active women for any other variables. CONCLUSION: Our results suggest that a higher level of physical activity can lead to a better quality of life.

scholarly journals The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0232693
Author(s):  
Øystein Rasch-Halvorsen ◽  
Erlend Hassel ◽  
Ben M. Brumpton ◽  
Haldor Jenssen ◽  
Martijn A. Spruit ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lung Function ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
Normal Lung ◽  
Normal Lung Function ◽  
Artery Disease

EEG-fMRI: Including sleep-induced potentials in the general linear model improves spatial accordance with epileptic focus

2010 ◽  
Vol 41 (02) ◽  
Author(s):  
J Möhring ◽  
D Coropceanu ◽  
F Möller ◽  
S Wolff ◽  
R Boor ◽  
...  
Keyword(s):  
Linear Model ◽  
General Linear Model ◽  
General Linear ◽  
Epileptic Focus
Sign in / Sign up

Export Citation Format

Share Document