scholarly journals Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis

2015 ◽  
Vol 9 (3) ◽  
pp. 166-174 ◽  
Author(s):  
Naga Jyothi Meka ◽  
Sridevi Ugrappa ◽  
Nagalaxmi Velpula ◽  
Sravan Kumar ◽  
Kotya Naik Maloth ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis

scholarly journals Coetaneous Presentation of Oral Leukoplakia and Oral Submucous Fibrosis with High Grade Dysplasia and Its Management with Lasers: A Case Report

2021 ◽  
Vol 6 (08) ◽  
pp. 464-469
Author(s):  
Preethi R ◽  
Malarkodi T ◽  
Arvind Krishnamurthy ◽  
Aravind Warrier S
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Oral Potentially Malignant Disorders ◽  
Oral Epithelial Dysplasia ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral potentially malignant disorders (OPMD) are diverse lesions associated with an increased likelihood for malignant transformation to oral cancer. The most frequently encountered OPMD in clinical practice are Oral Leukoplakia and oral submucous fibrosis (OSMF). The use of tobacco is consistently linked with leukoplakia and areca/betel nut with OSMF. Histopathological features of oral epithelial dysplasia, its varying grades are of immense clinical significance to evaluate its ability for malignant transformation. We report a case of homogenous leukoplakia and OSMF, two oral potentially malignant disorders occurring at the same site with high-grade dysplasia and its management using lasers.

Nuclear Blebbing Frequency in Tobacco-Induced Oral Potentially Malignant Disorders: A Pilot Study

2021 ◽  
pp. 1-8
Author(s):  
Roopa Yadahalli ◽  
Supriya Kheur ◽  
Aanchal Adwani ◽  
Ramesh Bhonde ◽  
A. Thirumal Raj ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Tobacco Use ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
Clinical Staging ◽  
Oral Potentially Malignant Disorders ◽  
Normal Oral Mucosa ◽  
Significant Difference ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

<b><i>Introduction:</i></b> Tobacco contains several genotoxic agents including N-nitrosamine which has the potential to cause significant nuclear damage. Nuclear blebbing is a form of protrusion on the nuclear membrane and could potentially be caused by tobacco-induced genotoxicity and is closely associated with malignancy. Thus, the present study aimed to assess if tobacco-associated oral potentially malignant disorders including oral submucous fibrosis (OSF) and oral leukoplakia have a higher nuclear blebbing frequency than patients with normal oral mucosa with no history of tobacco use. <b><i>Methods:</i></b> The sample consisted of patients with OSF (<i>n</i> = 30) and oral leukoplakia (<i>n</i> = 10) and normal oral mucosa (<i>n</i> = 10). Exfoliated cells collected from the study groups were smeared on a clean microscopic slide and stained by May-Grunwald-Giemsa stain. A baseline frequency of nuclear blebbing was evaluated using a bright-field microscope with a ×100 objective. The number of nuclear blebbing per 1,000 epithelial cells was recorded and expressed in percentage. ANOVA, the Mann-Whitney U test, and Spearman’s correlation were used to analyze the data. <b><i>Results:</i></b> The mean rank of distribution of nuclear blebbing showed significant difference between all 3 groups, with the highest frequency noted in leukoplakia, followed by oral submucous and normal oral mucosa. Within OSF, the frequency of nuclear blebbing significantly increased from early stage to advanced stage. In OSF, a statistically significant positive linear correlation was noted between duration (in years), frequency (per day) of tobacco use, clinical grading, and nuclear blebbing. <b><i>Discussion/Conclusions:</i></b> The frequency of nuclear blebbing was significantly higher in oral potentially malignant disorders than normal mucosa. Nuclear blebbing also exhibited a strong dose- and time-dependent correlation with tobacco usage and clinical staging in OSF. The nuclear blebbing frequency could be a noninvasive, economic tool to assess malignant risk in tobacco-induced oral potentially malignant disorders.

scholarly journals Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Arpita Kabiraj ◽  
Tanya Khaitan ◽  
Debarati Bhowmick ◽  
Uday Ginjupally ◽  
Aritri Bir ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Submucous Fibrosis ◽  
Class Ii ◽  
Class I ◽  
Exfoliative Cytology ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Oral Lichen

Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening.Materials and Method. A total of 160 subjects with 25–50 years of age were included in the study. Among them, 40 were clinically diagnosed with oral leukoplakia, 40 were diagnosed with oral lichen planus, 40 were diagnosed with oral submucous fibrosis, and 40 were in the control group. The prepared smears were subjected to Papanicolaou stain and analyzed microscopically for the evaluation of the cytomorphological features.Results and Discussion. When analyzed microscopically, 36 (90%) out of the 40 oral leukoplakic lesions showed Class II cytological features whereas 4 (10%) revealed Class I features. Among 40 patients with oral lichen planus, 26 (65%) showed Class II features while the remaining 14 (35%) revealed Class I features. In 40 subjects with oral submucous fibrosis, 32 (80%) showed Class II features while the other 8 (20%) showed Class I features. All the 40 control subjects showed Class I features. Thus, OEC can be widely advocated as an addition to clinical conclusion and an adjunct to biopsy.

scholarly journals Tobacco use, Body Mass Index, and Potentially Malignant Disorders among petrol fillers in Pimpri-Pune (India): A descriptive study

2014 ◽  
Vol 03 (04) ◽  
pp. 196-199
Author(s):  
Mamatha G.S. Reddy ◽  
Pradnya V. Kakodkar ◽  
Akanksha Singh
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Tobacco Use ◽  
Smokeless Tobacco ◽  
Oral Submucous Fibrosis ◽  
Descriptive Study ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Tobacco Chewing

Abstract Background: Since petrol is combustible and smoking is banned at the petrol pumps, it may be predicted that use of smokeless tobacco is more prevalent among the petrol fillers. Also, smokeless tobacco is a major risk factor for developing oral potentially malignant disorders. The present study was conducted to determine the tobacco use, body mass index (BMI), and potentially malignant disorders among a cohort of petrol fillers and also to evaluate the interaction of tobacco use and BMI with the presence of potentially malignant disorders. Settings and Design: The study was conducted at 45 petrol stations located at Pimpri-Pune, India. A descriptive study design was used. Materials and Method: Four hundred and ten petrol fillers aged 17-64 years participated in the study. General information and tobacco history was obtained by interview. Height and weight were recorded to obtain BMI. Oral examination was conducted to identify the potentially malignant disorders. Statistical analysis: Chi-square test, Z test, and logistic regression were used. The level of significance was fixed at 5%. Results and Conclusions: It was found that 242 (59.02%) used tobacco in different forms. 77.68% were tobacco chewers, and 8.26% were smokers. Leukoplakia was prevalent among 68.47%, oral submucous fibrosis among 27.45%, and 5.08% had erythroplakia. Age (χ2 = 11.46, P < 0.05), duration (χ2 = 17.46, P < 0.05), and frequency of tobacco chewing (χ2 = 14.16, P < 0.05) were significantly associated with potentially malignant disorders. Tobacco chewing was more prevalent as compared to smoking. It can be concluded that the petrol fillers are at a high risk for developing oral potentially malignant disorders.

scholarly journals Effectiveness of Long Term Supervised and Assisted Physiotherapy in Postsurgery Oral Submucous Fibrosis Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
S. Kale ◽  
N. Srivastava ◽  
V. Bagga ◽  
A. Shetty
Keyword(s):  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Scar Contracture ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Conservative And Surgical Treatment ◽  
Subsequent Relapse

Oral submucous fibrosis is one of the leading potentially malignant disorders prevailing in India. A number of conservative and surgical treatment options have been suggested for this potentially malignant disorder (Arakeri and Brennan, 2013). While the role of physiotherapy has been highlighted in the conservative management, its importance in postsurgical cases to avoid scar contracture and subsequent relapse has not been given due importance in the literature. The following is a case report of a male patient surgically treated for OSMF (oral submucous fibrosis) and meticulously followed up for recalls and physiotherapy. The constant supervision and motivation for physiotherapy along with the constant assistance helped achieve satisfying results.

scholarly journals Management of Histologically Proven Oral Submucous Fibrosis with Intralesional Steroids and Hyaluronidase- A Report of Two Cases

2021 ◽  
Author(s):  
R Preethi ◽  
S Aravind Warrier ◽  
CV Divyambika
Keyword(s):  
Clinical Symptoms ◽  
Oral Submucous Fibrosis ◽  
Burning Sensation ◽  
Treatment Modalities ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Randomised Controlled ◽  
Patients Experience

Oral Submucous Fibrosis (OSMF) is a chronic debilitating disease characterised by progressive fibrosis. The disease is predominantly seen in South East Asia and mainly attributed to areca nut chewing habit. The classical presentation includes generalised blanching with palpable fibrotic bands in the oral mucosa. Patients experience severe burning sensation, trismus and difficulty in gustatory functions, thus resulting in compromised nutritional status. The OSMF has been grouped under Oral Potentially Malignant Disorders (OPMD) and has high rates of malignant transformation. Although randomised controlled trials on different treatment modalities have been conducted, currently there is no effective medical management. This paper highlights two cases of OSMF presenting with severe burning sensation and trismus, who underwent incisional biopsy for histopathological confirmation and to rule out dysplasia. Both the patients were treated with dexamethasone and hyaluronidase, biweekly for four weeks. Post-treatment there was significant improvement in the clinical symptoms, thus providing the patients with better quality of life.

scholarly journals PENTINGNYA MENDETEKSI ORAL LEUKOPLAKIA SEBAGAI ORAL POTENTIALLY MALIGNANT DISORDERS (LAPORAN KASUS)

2019 ◽  
Vol 5 (2) ◽  
pp. 162-169
Author(s):  
Revi Nelonda ◽  
Tenny Setiani Dewi
Keyword(s):  
Histopathological Examination ◽  
Oral Lesion ◽  
Good Prognosis ◽  
Polymorphic Form ◽  
Oral Leukoplakia ◽  
Histopathologic Examination ◽  
Normal Range ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Oral Leukoplakia (OL) is white plaque lesion in oral mucosa thatcannot be scraped and one of Oral Potentially Malignant Disorder(OPMD) with incidence about 2.5% of all populations in the world.The most case of oral squamous cell carcinoma are preceded byOPMD. The aim of this case report is to understand the importance ofdetection oral lesion that could potentially become malignancy. A 28-year-old male patient complained of sores on his tongue that had nothealed for 2 months. Intraoral examination obtained red and whitelesion on the left lateral tongue: shallow reddish ulcer with irregularborder in region 35-36, followed by unscrapable white plaque lesionwith slight induration in region 37-38. Hematological examinationshowed normal range. According anamnesis and clinical examination,diagnosis of traumatic ulcer and OL were made. Patients were treatedwith multivitamins and antiseptic mouthwash. Histopathologicalexamination results from lesion biopsies show a hyperplastic mass,parakeratosis and a tissue with polymorphic form, a hyperchromaticnucleus of cells associated with histopathologic criteria of squamouscell carcinomas with well differentiation. The patient was referred tothe Hemato-oncology Department for chemotherapy. There are twoimportant parameters should be considered when evaluating thepotential for malignant change of OL that is when finding white lesionswith or without red lesions should always be suspected as OPMD andalways confirm it by histopathological examination as early aspossible. Accurate examination and histopathologic examination isessential to obtain a good prognosis in OPMD.

scholarly journals Comparison of dermatoglyphic patterns in oral leukoplakia and oral submucous fibrosis patients

2019 ◽  
Vol 8 (1) ◽  
pp. 153
Author(s):  
Venkatesh V. Kulkarni ◽  
Aditi R. Chaudhari ◽  
Aishwarya S. Kulkarni
Keyword(s):  
Healthy Subjects ◽  
Preventive Measures ◽  
Oral Submucous Fibrosis ◽  
Malignant Lesion ◽  
Oral Leukoplakia ◽  
Oral Lesions ◽  
Major Contributor ◽  
Loop Pattern ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Background: Genetics plays an important role in the detection of an Oral potentially malignant lesion. A major contributor to genetic study is Dermatoglyphics or the study of fingerprints and lines of palmer and plantar surfaces. Many researchers have used dermatoglyphics to connect genetics with oral lesions and malignancies. Thus, the current study has been conducted to find out an association between dermatoglyphic patterns and oral leukoplakia, oral submucous fibrosis and healthy subjects.Methods: The present study is conducted on subjects that have been already diagnosed with oral lesions. Fingerprint patterns (whorled, loop and arch) were evaluated by utilizing fingerprints.Results: The present study showed that the loop pattern was common in all three subjects. The frequency of whorled and arch pattern is decreased in oral leukoplakia and oral submucous fibrosis that healthy subjects. Arch pattern is comparatively decreased in subjects with oral leukoplakia than oral submucous fibrosis and there is a decrease in the frequency of whorled patterns in OSMF as compared to oral leukoplakia.Conclusions: Authors conclude that simply by observing the whorled and arch patterns in a subject, authors can hypothesize that risk of occurrence of oral leukoplakia and oral submucous Fibrosis and take preventive measures against the said lesions.

scholarly journals Deep Learning Predicts the Malignant-Transformation-Free Survival of Oral Potentially Malignant Disorders

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6054
Author(s):  
John Adeoye ◽  
Mohamad Koohi-Moghadam ◽  
Anthony Wing Ip Lo ◽  
Raymond King-Yin Tsang ◽  
Velda Ling Yu Chow ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Malignant Transformation ◽  
Cross Validation ◽  
Machine Intelligence ◽  
Oral Leukoplakia ◽  
Time To Event ◽  
Oral Potentially Malignant Disorders ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Machine-intelligence platforms for the prediction of the probability of malignant transformation of oral potentially malignant disorders are required as adjunctive decision-making platforms in contemporary clinical practice. This study utilized time-to-event learning models to predict malignant transformation in oral leukoplakia and oral lichenoid lesions. A total of 1098 patients with oral white lesions from two institutions were included in this study. In all, 26 features available from electronic health records were used to train four learning algorithms—Cox-Time, DeepHit, DeepSurv, random survival forest (RSF)—and one standard statistical method—Cox proportional hazards model. Discriminatory performance, calibration of survival estimates, and model stability were assessed using a concordance index (c-index), integrated Brier score (IBS), and standard deviation of the averaged c-index and IBS following training cross-validation. This study found that DeepSurv (c-index: 0.95, IBS: 0.04) and RSF (c-index: 0.91, IBS: 0.03) were the two outperforming models based on discrimination and calibration following internal validation. However, DeepSurv was more stable than RSF upon cross-validation. External validation confirmed the utility of DeepSurv for discrimination (c-index—0.82 vs. 0.73) and RSF for individual survival estimates (0.18 vs. 0.03). We deployed the DeepSurv model to encourage incipient application in clinical practice. Overall, time-to-event models are successful in predicting the malignant transformation of oral leukoplakia and oral lichenoid lesions.

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