scholarly journals Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

2018 ◽  
Vol 7 (1) ◽  
pp. 25-31
Author(s):  
Ali Hasanpour Dehkordi ◽  
Majid Dousti ◽  
Faezeh Kiani ◽  
Mona Zamanian Azodi ◽  
Mostafa RezaeiTavirani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 30 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Juan Manuel Guzmán-Flores ◽  
José Francisco Muñoz-Valle ◽  
José Sánchez-Corona ◽  
José G. Cobián ◽  
Leopoldo Medina-Carrillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-αgene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR—RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07–2.29;p= 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05–2.31;p= 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

scholarly journals ASSOCIATION OF SERUM TNF- A WITH INSULIN RESISTANCE IN PRE-DIABETES AND TYPE 2 DIABETES MELLITUS

2021 ◽  
Vol 9 (10) ◽  
pp. 1406-1410
Author(s):  
Poorvi Gupta ◽  
◽  
P.J. Hisalkar ◽  
Neerja Mallick ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Background- First adipocyte derived biomarker is tumor necrosis factor alpha which connect the link between inflammation and diabetes. It expresses m-RNA which is contributing to the development of insulin resistance. However, the relationship between tumor necrosis factor alpha, pre-diabetes and Type2diabetes mellitus is still contradictory and restricted. Material & Methods: This study was hospital based analytical cross-sectional study. Total 900 subjects were distributed into three groups (300 pre-diabetic subjects, 300 type 2 diabetic subjects and 300 healthy subjects) as per ADA criteria. The biochemical parameters as Fasting Blood Glucose, 2-hr glucose (after 75 gm oral glucose intake), HbA1c and fasting insulin were analyzed. HOMA-IR was used to calculate insulin resistance mathematically. Anthropometric measurements were done. Tumor necrosis factor alpha was done by ELISA method. Results: Tumor necrosis factor alpha concentration was significantly increased in patients with type 2 diabetes mellitus and pre-diabetes in comparison to the control group at p value < 0.001 and showed a positive correlation with HOMA -IR. In conclusion, our findings suggested that systemic inflammation has an important role in the pathogenesis of pre diabetic condition. There is a progressive raises value of tumor necrosis factor alpha in pre diabetic and diabetic patients. Therefore, inflammation reflects the severity of the disease and signifies the presence of ongoing disease process.

scholarly journals Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Jie Xu ◽  
Yan Hong Zhao ◽  
Yun Ping Chen ◽  
Xiao Lei Yuan ◽  
Jiao Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Tumor Necrosis Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. A systematic search of PubMed and Medline was undertaken. In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0. The results showed that maternal TNF-α(P=0.0003) and leptin (P<0.00001) concentrations were significantly higher in GDM patients versus controls. However, maternal adiponectin (P<0.00001) concentration was significantly lower in GDM patients compared with controls. Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-αand leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals. Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.

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