Tumor Necrosis Factor-Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus

2017 ◽  
Vol 119 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Muhammad Sajid Hamid Akash ◽  
Kanwal Rehman ◽  
Aamira Liaqat
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

2011 ◽  
Vol 30 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Juan Manuel Guzmán-Flores ◽  
José Francisco Muñoz-Valle ◽  
José Sánchez-Corona ◽  
José G. Cobián ◽  
Leopoldo Medina-Carrillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-αgene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR—RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07–2.29;p= 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05–2.31;p= 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

scholarly journals ASSOCIATION OF SERUM TNF- A WITH INSULIN RESISTANCE IN PRE-DIABETES AND TYPE 2 DIABETES MELLITUS

2021 ◽  
Vol 9 (10) ◽  
pp. 1406-1410
Author(s):  
Poorvi Gupta ◽  
◽  
P.J. Hisalkar ◽  
Neerja Mallick ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Background- First adipocyte derived biomarker is tumor necrosis factor alpha which connect the link between inflammation and diabetes. It expresses m-RNA which is contributing to the development of insulin resistance. However, the relationship between tumor necrosis factor alpha, pre-diabetes and Type2diabetes mellitus is still contradictory and restricted. Material & Methods: This study was hospital based analytical cross-sectional study. Total 900 subjects were distributed into three groups (300 pre-diabetic subjects, 300 type 2 diabetic subjects and 300 healthy subjects) as per ADA criteria. The biochemical parameters as Fasting Blood Glucose, 2-hr glucose (after 75 gm oral glucose intake), HbA1c and fasting insulin were analyzed. HOMA-IR was used to calculate insulin resistance mathematically. Anthropometric measurements were done. Tumor necrosis factor alpha was done by ELISA method. Results: Tumor necrosis factor alpha concentration was significantly increased in patients with type 2 diabetes mellitus and pre-diabetes in comparison to the control group at p value < 0.001 and showed a positive correlation with HOMA -IR. In conclusion, our findings suggested that systemic inflammation has an important role in the pathogenesis of pre diabetic condition. There is a progressive raises value of tumor necrosis factor alpha in pre diabetic and diabetic patients. Therefore, inflammation reflects the severity of the disease and signifies the presence of ongoing disease process.

scholarly journals Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

2018 ◽  
Vol 7 (1) ◽  
pp. 25-31
Author(s):  
Ali Hasanpour Dehkordi ◽  
Majid Dousti ◽  
Faezeh Kiani ◽  
Mona Zamanian Azodi ◽  
Mostafa RezaeiTavirani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Suppressive Effects of Insulin on Tumor Necrosis Factor–Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus

2016 ◽  
Vol 68 (6) ◽  
pp. 1392-1402 ◽  
Author(s):  
Daisuke Hamada ◽  
Robert Maynard ◽  
Eric Schott ◽  
Christopher J. Drinkwater ◽  
John P. Ketz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Necrosis Factor

scholarly journals Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jirayu Lainampetch ◽  
Pornpimol Panprathip ◽  
Chanchira Phosat ◽  
Noppanath Chumpathat ◽  
Pattaneeya Prangthip ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Inflammatory Marker ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Factor Alpha ◽  
Necrosis Factor

The linkage of obesity, inflammation, and type 2 diabetes mellitus (T2DM) has been extensively investigated for over a decade. However, the association between inflammatory biomarkers, including C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α), and T2DM is still inconsistent and limited. Thus, this study is aimed at elucidating the association between inflammatory marker levels and the risk of developing T2DM in many aspects. Among 296 subjects enrolled in 2013, 248 non-T2DM subjects who were completely reinvestigated in 2014 and 2015 were included in a 2-year retrospective analysis. Multivariate logistic regression was performed to evaluate the association of baseline inflammatory marker levels and variation with incidence of T2DM. After the 2-year follow-up, 18.6% of total subjects had developed T2DM. The risk of developing T2DM was significantly increased in subjects with a high level of baseline CRP (OR=4.02, 95% CI: 1.77-9.12, P=0.001), and a stronger impact was found with the combination of high CRP and IL-6 levels (OR=5.11, 95% CI: 1.27-20.49, P=0.021). One-year inflammatory marker variation analysis also revealed the significant association of elevated TNF-α and risk of developing T2DM (OR=4.88, 95% CI: 1.01-23.49, P=0.048). In conclusion, besides consideration of CRP levels alone, our findings suggested that IL-6 outstandingly plays a contributing role in T2DM progression and elevated TNF-α levels over time could be a potential predictor of T2DM.

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