Emerging Advanced Nanomaterials for Cancer Photothermal Therapy

2018 ◽  
Vol 53 (2) ◽  
pp. 131-146 ◽  
Author(s):  
Haohao Zhang ◽  
Guihuan Chen ◽  
Bing Yu ◽  
Hailin Cong
Keyword(s):  
Minimally Invasive ◽  
Cancer Cells ◽  
Photon Energy ◽  
Conversion Efficiency ◽  
Future Development ◽  
Metabolic Pathway ◽  
Photothermal Therapy ◽  
Water Solubility ◽  
Heat Energy ◽  
Invasive Technique

Abstract As a new minimally invasive technique, photothermal therapy has attracted worldwide attention in the treatment of cancer. Photothermal therapy kills cancer cells by converting photon energy into heat energy. At the time of selection, the photothermal agents will be required to be water solubility, cytotoxicity, high photothermal conversion efficiency, metabolic pathway and so on. This report introduces the current research status of various nanoparticles used in photothermal therapy, and looks forward to the future development of photothermal therapy.

Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma

2014 ◽  
Vol 2 (23) ◽  
pp. 3686-3696 ◽  
Author(s):  
Zhenglin Li ◽  
Yongyi Zeng ◽  
Da Zhang ◽  
Ming Wu ◽  
Lingjie Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Minimally Invasive ◽  
Prussian Blue ◽  
Photothermal Therapy ◽  
Minimally Invasive Technique ◽  
Invasive Technique ◽  
Prussian Blue Nanoparticles ◽  
Mri Guided

MRI-guided photothermal therapy is becoming a more widely accepted minimally invasive technique.

scholarly journals Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1307 ◽  
Author(s):  
Oscar Knights ◽  
Steven Freear ◽  
James R. McLaughlan
Keyword(s):  
Lung Cancer ◽  
Minimally Invasive ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Continuous Wave ◽  
Treatment Options ◽  
Lung Cancer Cells ◽  
Heat Conducting

Lung cancer is a particularly difficult form of cancer to diagnose and treat, due largely to the inaccessibility of tumours and the limited available treatment options. The development of plasmonic gold nanoparticles has led to their potential use in a large range of disciplines, and they have shown promise for applications in this area. The ability to functionalise these nanoparticles to target to specific cancer types, when combined with minimally invasive therapies such as photothermal therapy, could improve long-term outcomes for lung cancer patients. Conventionally, continuous wave lasers are used to generate bulk heating enhanced by gold nanorods that have accumulated in the target region. However, there are potential negative side-effects of heat-induced cell death, such as the risk of damage to healthy tissue due to heat conducting to the surrounding environment, and the development of heat and drug resistance. In this study, the use of pulsed lasers for photothermal therapy was investigated and compared with continuous wave lasers for gold nanorods with a surface plasmon resonance at 850 nm, which were functionalised with anti-EGFR antibodies. Photothermal therapy was performed with both laser systems, on lung cancer cells (A549) in vitro populations incubated with untargeted and targeted nanorods. It was shown that the combination of pulse wave laser illumination of targeted nanoparticles produced a reduction of 93 % ± 13 % in the cell viability compared with control exposures, which demonstrates a possible application for minimally invasive therapies for lung cancer.

Cu7.2S4 nanocrystals: a novel photothermal agent with a 56.7% photothermal conversion efficiency for photothermal therapy of cancer cells

Nanoscale ◽  
2014 ◽  
Vol 6 (6) ◽  
pp. 3274 ◽  
Author(s):  
Bo Li ◽  
Qian Wang ◽  
Rujia Zou ◽  
Xijian Liu ◽  
Kaibing Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Photothermal Conversion

Non-Destructive, Dynamic Imaging of HSP70 Response to Nanoparticle Mediated Photothermal Therapy in a 3D Tumor Mimic

2012 ◽  
Author(s):  
Matthew DeWitt ◽  
Bryce Whited ◽  
Matthias C. Hofmann ◽  
Peng Lu ◽  
Yong Xu ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Photothermal Therapy ◽  
Laser Energy ◽  
Tissue Sample ◽  
Dynamic Imaging ◽  
Invasive Technique ◽  
Additional Absorption ◽  
Carbon Nanohorns ◽  
Non Destructive ◽  
Cancerous Cells

Laser based photothermal therapy is a minimally invasive technique that relies on the absorption of energy by an irradiated tissue sample and results in the deposition of heat to destroy cancerous cells. The inclusion of nanoparticles that act as intense infrared absorbers allows for higher selectivity and additional absorption of laser energy into heat in the desired material. One promising carbonaceous nanoparticle is single walled carbon nanohorns (SWNHs) which have been demonstrated to be effective photoabsorbers [1].

scholarly journals Designing highly stable ferrous selenide-black phosphorus nanosheets heteronanostructure via P-Se bond for MRI-guided photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xuanru Deng ◽  
Hongxing Liu ◽  
Yuan Xu ◽  
Leung Chan ◽  
Jun Xie ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Water Solubility ◽  
Tumor Therapy ◽  
Lone Pair ◽  
Black Phosphorus ◽  
Photothermal Conversion ◽  
Mri Guided ◽  
Theranostic Agents ◽  
Lone Pair Electrons

Abstract Background The design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is imminent. Results Herein, black phosphorus nanosheets (BPs) covalently with mono-dispersed and superparamagnetic ferrous selenide (FeSe2) to construct heteronanostructure nanoparticles modified with methoxy poly (Ethylene Glycol) (mPEG-NH2) to obtain good water solubility for MRI-guided photothermal tumor therapy is successfully designed. The mechanism reveals that the enhanced photothermal conversion achieved by BPs-FeSe2-PEG heteronanostructure is attributed to the effective separation of photoinduced carriers. Besides, through the formation of the P-Se bond, the oxidation degree of FeSe2 is weakened. The lone pair electrons on the surface of BPs are occupied, which reduces the exposure of lone pair electrons in air, leading to excellent stability of BPs-FeSe2-PEG. Furthermore, the BPs-FeSe2-PEG heteronanostructure could realize enhanced T2-weighted imaging due to the aggregation of FeSe2 on BPs and the formation of hydrogen bonds, thus providing accurate PTT guidance and generating hyperthermia to inhabit tumor growth under NIR laser with negligible toxicity in vivo. Conclusions Collectively, this work offers an opportunity for fabricating BPs-based heteronanostructure nanomaterials that could simultaneously enhance photothermal conversion efficiency and photostability to realize MRI-guided cancer therapy. Graphic abstract

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

Single-chain antibody-decorated Au nanocages@liposomal layer nanoprobes for targeted SERS imaging and remote-controlled photothermal therapy of melanoma cancer cells

2021 ◽  
Vol 124 ◽  
pp. 112086
Author(s):  
Ghazal Farahavar ◽  
Samira Sadat Abolmaali ◽  
Foroogh Nejatollahi ◽  
Amin Safaie ◽  
Sanaz Javanmardi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Melanoma Cancer ◽  
Sers Imaging
Sign in / Sign up

Export Citation Format

Share Document