Non-Destructive, Dynamic Imaging of HSP70 Response to Nanoparticle Mediated Photothermal Therapy in a 3D Tumor Mimic

2012 ◽  
Author(s):  
Matthew DeWitt ◽  
Bryce Whited ◽  
Matthias C. Hofmann ◽  
Peng Lu ◽  
Yong Xu ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Photothermal Therapy ◽  
Laser Energy ◽  
Tissue Sample ◽  
Dynamic Imaging ◽  
Invasive Technique ◽  
Additional Absorption ◽  
Carbon Nanohorns ◽  
Non Destructive ◽  
Cancerous Cells

Laser based photothermal therapy is a minimally invasive technique that relies on the absorption of energy by an irradiated tissue sample and results in the deposition of heat to destroy cancerous cells. The inclusion of nanoparticles that act as intense infrared absorbers allows for higher selectivity and additional absorption of laser energy into heat in the desired material. One promising carbonaceous nanoparticle is single walled carbon nanohorns (SWNHs) which have been demonstrated to be effective photoabsorbers [1].

Emerging Advanced Nanomaterials for Cancer Photothermal Therapy

2018 ◽  
Vol 53 (2) ◽  
pp. 131-146 ◽  
Author(s):  
Haohao Zhang ◽  
Guihuan Chen ◽  
Bing Yu ◽  
Hailin Cong
Keyword(s):  
Minimally Invasive ◽  
Cancer Cells ◽  
Photon Energy ◽  
Conversion Efficiency ◽  
Future Development ◽  
Metabolic Pathway ◽  
Photothermal Therapy ◽  
Water Solubility ◽  
Heat Energy ◽  
Invasive Technique

Abstract As a new minimally invasive technique, photothermal therapy has attracted worldwide attention in the treatment of cancer. Photothermal therapy kills cancer cells by converting photon energy into heat energy. At the time of selection, the photothermal agents will be required to be water solubility, cytotoxicity, high photothermal conversion efficiency, metabolic pathway and so on. This report introduces the current research status of various nanoparticles used in photothermal therapy, and looks forward to the future development of photothermal therapy.

Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma

2014 ◽  
Vol 2 (23) ◽  
pp. 3686-3696 ◽  
Author(s):  
Zhenglin Li ◽  
Yongyi Zeng ◽  
Da Zhang ◽  
Ming Wu ◽  
Lingjie Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Minimally Invasive ◽  
Prussian Blue ◽  
Photothermal Therapy ◽  
Minimally Invasive Technique ◽  
Invasive Technique ◽  
Prussian Blue Nanoparticles ◽  
Mri Guided

MRI-guided photothermal therapy is becoming a more widely accepted minimally invasive technique.

A novel robot-guided minimally invasive technique for brain tumor biopsies

2020 ◽  
Vol 132 (1) ◽  
pp. 150-158
Author(s):  
Georgi Minchev ◽  
Gernot Kronreif ◽  
Wolfgang Ptacek ◽  
Christian Dorfer ◽  
Alexander Micko ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Tissue Sample ◽  
Operating Time ◽  
Skin Incision ◽  
Subsequent Treatment ◽  
Burr Hole ◽  
Invasive Technique ◽  
Consecutive Series ◽  
Robotic Devices ◽  
Stereotactic Biopsies

OBJECTIVEAs decisions regarding tumor diagnosis and subsequent treatment are increasingly based on molecular pathology, the frequency of brain biopsies is increasing. Robotic devices overcome limitations of frame-based and frameless techniques in terms of accuracy and usability. The aim of the present study was to present a novel, minimally invasive, robot-guided biopsy technique and compare the results with those of standard burr hole biopsy.METHODSA tubular minimally invasive instrument set was custom-designed for the iSYS-1 robot-guided biopsies. Feasibility, accuracy, duration, and outcome were compared in a consecutive series of 66 cases of robot-guided stereotactic biopsies between the minimally invasive (32 patients) and standard (34 patients) procedures.RESULTSApplication of the minimally invasive instrument set was feasible in all patients. Compared with the standard burr hole technique, accuracy was significantly higher both at entry (median 1.5 mm [range 0.2–3.2 mm] vs 1.7 mm [range 0.8–5.1 mm], p = 0.008) and at target (median 1.5 mm [range 0.4–3.4 mm] vs 2.0 mm [range 0.8–3.9 mm], p = 0.019). The incision-to-suture time was significantly shorter (median 30 minutes [range 15–50 minutes] vs 37.5 minutes [range 25–105 minutes], p < 0.001). The skin incision was significantly shorter (median 16.3 mm [range 12.7–23.4 mm] vs 28.4 mm [range 20–42.2 mm], p = 0.002). A diagnostic tissue sample was obtained in all cases.CONCLUSIONSApplication of the novel instrument set was feasible in all patients. According to the authors’ data, the minimally invasive robot-guidance procedure can significantly improve accuracy, reduce operating time, and improve the cosmetic result of stereotactic biopsies.

A 3D Microfluidic Tumor Construct to Determine Transport and Photothermal Properties of Single Walled Nanohorns

2013 ◽  
Author(s):  
Matthew DeWitt ◽  
Cara Buchanan ◽  
Allison Pekkanen ◽  
M. Nichole Rylander
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Thermal Damage ◽  
Laser Energy ◽  
Low Cost ◽  
Region Of Interest ◽  
Wavelength Band ◽  
Additional Absorption ◽  
Non Invasive ◽  
Tumor Region

Photothermal therapy is a cancer treatment that utilizes light energy to deposit specific amounts of heat to effectively kill cells in a specified tumor region. While Hyperthermia has been widely used for centuries as a treatment option for a variety of diseases, Localized Hyperthermia, as seen in photothermal therapies, has seen a rapid increase in use as a cancer treatment due to its non-invasive nature, low cost, simplicity, and reduced complications as compared to other currently available resection options [1]. The inclusion of nanoparticles that are capable of intense absorption in a specific wavelength band allows for higher selectivity of this thermal dose based upon the location of the delivered nanoparticles through both the additional absorption of laser energy, which gets deposited as heat, in the desired location containing the photoabsorbers and by lowering the amount of energy or power of the laser necessary to affect the region of interest, thus lowering the energy applied to the non-desired thermal damage region.

scholarly journals Microsurgical unilateral laminotomy for bilateral decompression of degenerative lumbar canal stenosis: a comparative study

2019 ◽  
Vol 55 (1) ◽  
Author(s):  
Mohamed I. Refaat ◽  
Amr K. Elsamman ◽  
Adham Rabea ◽  
Mohamed I. A. Hewaidy
Keyword(s):  
Patient Satisfaction ◽  
Blood Loss ◽  
Minimally Invasive ◽  
Invasive Technique ◽  
Decompression Surgery ◽  
Microsurgical Decompression ◽  
Significant Difference ◽  
Duration Of Surgery ◽  
Group A ◽  
Group B

Abstract Background The quest for better patient outcomes is driving to the development of minimally invasive spine surgical techniques. There are several evidences on the use of microsurgical decompression surgery for degenerative lumbar spine stenosis; however, few of these studies compared their outcomes with the traditional laminectomy technique. Objectives The aim of our study was to compare outcomes following microsurgical decompression via unilateral laminotomy for bilateral decompression (ULBD) of the spinal canal to the standard open laminectomy for cases with lumbar spinal stenosis. Subjects and methods Cases were divided in two groups. Group (A) cases were operated by conventional full laminectomy; Group (B) cases were operated by (ULBD) technique. Results from both groups were compared regarding duration of surgery, blood loss, perioperative complication, and postoperative outcome and patient satisfaction. Results There was no statistically significant difference between both groups regarding the improvement of visual pain analogue, while improvement of neurogenic claudication outcome score was significant in group (B) than group (A). Seventy-three percent of group (A) cases and 80% of group (B) stated that surgery met their expectations and were satisfied from the outcome. Conclusion Comparing ULBD with traditional laminectomy showed the efficacy of the minimally invasive technique in obtaining good surgical outcome and patient satisfaction. There was no statistically significant difference between both groups regarding the occurrence of complications The ULBD technique was found to respect the posterior spinal integrity and musculature, accompanied with less blood loss, shorter hospital stays, and shorter recovery periods than the open laminectomy technique.

scholarly journals Endovascular Bariatric Surgery as Novel Minimally Invasive Technique for Weight Management in the Morbidly Obese: Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2541
Author(s):  
Giuseppe Massimo Sangiorgi ◽  
Alberto Cereda ◽  
Nicola Porchetta ◽  
Daniela Benedetto ◽  
Andrea Matteucci ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Minimally Invasive ◽  
Weight Management ◽  
World Health ◽  
Invasive Technique ◽  
Morbidly Obese ◽  
World Population ◽  
Obese Patients ◽  
The World ◽  
Open Bariatric Surgery

Nowadays, obesity represents one of the most unresolved global pandemics, posing a critical health issue in developed countries. According to the World Health Organization, its prevalence has tripled since 1975, reaching a prevalence of 13% of the world population in 2016. Indeed, as obesity increases worldwide, novel strategies to fight this condition are of the utmost importance to reduce obese-related morbidity and overall mortality related to its complications. Early experimental and initial clinical data have suggested that endovascular bariatric surgery (EBS) may be a promising technique to reduce weight and hormonal imbalance in the obese population. Compared to open bariatric surgery and minimally invasive surgery (MIS), EBS is much less invasive, well tolerated, with a shorter recovery time, and is probably cost-saving. However, there are still several technical aspects to investigate before EBS can be routinely offered to all obese patients. Further prospective studies and eventually a randomized trial comparing open bariatric surgery vs. EBS are needed, powered for clinically relevant outcomes, and with adequate follow-up. Yet, EBS may already appear as an appealing alternative treatment for weight management and cardiovascular prevention in morbidly obese patients at high surgical risk.

scholarly journals Microendoscopy-assisted extraforaminal lumbar interbody fusion for treating single-level spondylodesis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Motohide Shibayama ◽  
Guang Hua Li ◽  
Li Guo Zhu ◽  
Zenya Ito ◽  
Fujio Ito
Keyword(s):  
Minimally Invasive ◽  
Spinal Canal ◽  
Interbody Fusion ◽  
Facet Joint ◽  
Clinical Results ◽  
Invasive Technique ◽  
Clinical Effects ◽  
Lumbar Interbody Fusion ◽  
Disc Space ◽  
Single Level

Abstract Background Lumbar interbody fusion is a standard technique for treating degenerative lumbar disorders involving instability. Due to its invasiveness, a minimally invasive technique, extraforaminal lumbar interbody fusion (ELIF), was introduced. On surgically approaching posterolaterally, the posterior muscles and spinal canal are barely invaded. Despite its theoretical advantage, ELIF is technically demanding and has not been popularised. Therefore, we developed a microendoscopy-assisted ELIF (mELIF) technique which was designed to be safe and less invasive. Here, we aimed to report on the surgical technique and clinical results. Methods Using a posterolateral approach similar to that of lateral disc herniation surgery, a tubular retractor, 16 or 18 mm in diameter, was placed at the lateral aspect of the facet joint. The facet joint was partially excised, and the disc space was cleaned. A cage and local bone graft were inserted into the disc space. All disc-related procedures were performed under microendoscopy. The spinal canal was not invaded. Bilateral percutaneous screw-rod constructs were inserted and fixed. Results Fifty-five patients underwent the procedure. The Oswestry Disability Index and visual analogue scale scores greatly improved. Over 90% of the patients obtained excellent or good results based on Macnab’s criteria. There were neither major adverse clinical effects nor the need for additional surgery. Conclusions mELIF is minimally invasive because the spinal canal and posterior muscles are barely invaded. It produces good clinical results with fewer complications. This technique can be applied in most single-level spondylodesis cases, including those involving L5/S1 disorders.

The Emerging Role of Robotic Single-site Approach for Myomectomy: A Systematic Review of the Literature

2021 ◽  
pp. 155335062098822
Author(s):  
Eirini Giovannopoulou ◽  
Anastasia Prodromidou ◽  
Nikolaos Blontzos ◽  
Christos Iavazzo
Keyword(s):  
Blood Loss ◽  
Minimally Invasive ◽  
Complication Rate ◽  
Operative Time ◽  
Intraoperative Complications ◽  
Single Site ◽  
Minimally Invasive Technique ◽  
Invasive Technique ◽  
Robotic Myomectomy ◽  
The Mean

Objective. To review the existing studies on single-site robotic myomectomy and test the safety and feasibility of this innovative minimally invasive technique. Data Sources. PubMed, Scopus, Google Scholar (from their inception to October 2019), as well as Clinicaltrials.gov databases up to April 2020. Methods of Study Selection. Clinical trials (prospective or retrospective) that reported the outcomes of single-site robotic myomectomy, with a sample of at least 20 patients were considered eligible for the review. Results. The present review was performed in accordance with the guidelines for Systematic Reviews and Meta-Analyses (PRISMA). Four (4) studies met the inclusion criteria, and a total of 267 patients were included with a mean age from 37.1 to 39.1 years and BMI from 21.6 to 29.4 kg/m2. The mean operative time ranged from 131.4 to 154.2 min, the mean docking time from 5.1 to 5.45 min, and the mean blood loss from 57.9 to 182.62 ml. No intraoperative complications were observed, and a conversion rate of 3.8% was reported by a sole study. The overall postoperative complication rate was estimated at 2.2%, and the mean hospital stay ranged from 0.57 to 4.7 days. No significant differences were detected when single-site robotic myomectomy was compared to the multiport technique concerning operative time, blood loss, and total complication rate. Conclusion. Our findings support the safety of single-site robotic myomectomy and its equivalency with the multiport technique on the most studied outcomes. Further studies are needed to conclude on the optimal minimally invasive technique for myomectomy.

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