scholarly journals Engineered nanomaterials and human health: Part 2. Applications and nanotoxicology (IUPAC Technical Report)

2018 ◽  
Vol 90 (8) ◽  
pp. 1325-1356 ◽  
Author(s):  
Vladimir Gubala ◽  
Linda J. Johnston ◽  
Harald F. Krug ◽  
Colin J. Moore ◽  
Christopher K. Ober ◽  
...  

AbstractResearch on engineered nanomaterials (ENM) has progressed rapidly from the very early stages of studying their unique, size-dependent physicochemical properties and commercial exploration to the development of products that influence our everyday lives. We have previously reviewed various methods for synthesis, surface functionalization, and analytical characterization of ENM in a publication titled ‘Engineered Nanomaterials: Preparation, Functionalization and Characterization’. In this second, inter-linked document, we first provide an overview of important applications of ENM in products relevant to human healthcare and consumer goods, such as food, textiles, and cosmetics. We then highlight the challenges for the design and development of new ENM for bio-applications, particularly in the rapidly developing nanomedicine sector. The second part of this document is dedicated to nanotoxicology studies of ENM in consumer products. We describe the various biological targets where toxicity may occur, summarize the four nanotoxicology principles, and discuss the need for careful consideration of the biodistribution, degradation, and elimination routes of nanosized materials before they can be safely used. Finally, we review expert opinions on the risk, regulation, and ethical aspects of using engineered nanomaterials in applications that may have direct or indirect impact on human health or our environment.

2018 ◽  
Vol 90 (8) ◽  
pp. 1283-1324 ◽  
Author(s):  
Vladimir Gubala ◽  
Linda J. Johnston ◽  
Ziwei Liu ◽  
Harald Krug ◽  
Colin J. Moore ◽  
...  

Abstract Nanotechnology is a rapidly evolving field, as evidenced by the large number of publications on the synthesis, characterization, and biological/environmental effects of new nano-sized materials. The unique, size-dependent properties of nanomaterials have been exploited in a diverse range of applications and in many examples of nano-enabled consumer products. In this account we focus on Engineered Nanomaterials (ENM), a class of deliberately designed and constructed nano-sized materials. Due to the large volume of publications, we separated the preparation and characterisation of ENM from applications and toxicity into two interconnected documents. Part 1 summarizes nanomaterial terminology and provides an overview of the best practices for their preparation, surface functionalization, and analytical characterization. Part 2 (this issue, Pure Appl. Chem. 2018; 90(8): 1325–1356) focuses on ENM that are used in products that are expected to come in close contact with consumers. It reviews nanomaterials used in therapeutics, diagnostics, and consumer goods and summarizes current nanotoxicology challenges and the current state of nanomaterial regulation, providing insight on the growing public debate on whether the environmental and social costs of nanotechnology outweigh its potential benefits.


Author(s):  
Anne Steinemann

Abstract Fragrance is used in consumer products around the world. However, fragrance has been associated with adverse effects on indoor and outdoor air quality and human health. Questions arise, such as the following: Why does fragrance in products pose problems? What are sources of emissions and exposures? What are health and societal effects? What are possible solutions? This paper examines the issue of fragranced consumer products and its science and policy dimensions, with a focus on the implications for air quality and human health. Results include new findings and new questions for future research directions.


2019 ◽  
Vol 653 ◽  
pp. 423-430 ◽  
Author(s):  
Zhiguo Cao ◽  
Mengmeng Wang ◽  
Qiaoying Chen ◽  
Chunyou Zhu ◽  
Janye Jie ◽  
...  

2019 ◽  
Vol 86 (2) ◽  
pp. 22-28
Author(s):  
G.M. Balan ◽  
S.D. Kolesnyk ◽  
P.G. Zhminko ◽  
N.M. Bubalo ◽  
V.A. Babych

Objective is to summarise current literature data on the adverse effects of triclosan (TCS) biocide on human and animal health and potential risk for the development of endocrine-disruptor effects forjustification of the necessity to improve regulatory measures for its use in consumer products. Material and Methods. Analysis of literature data on the ways of influence of metabolic transformation in the body and toxicokinetics of TCS, its influence on human health and environment was performed. Targets and biomarkers of TCS exposure, its toxic properties and potential risk for the formation of endocrine-disruptor effects were described. Results. Necessity to optimise regulatory measures for the use of TCS in the personal hygienic means, general and curative beauty products, woven fabric for bedlinen and underwear, etc. has been justified. Key Words: triclosan biocide, toxic properties, endocrine-disruptor effects, regulatory measures.


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