Premature closure of foramen ovale and renal vein thrombosis in a stillborn twin homozygous for methylene tetrahydrofolate reductase gene polymorphism: A clinicopathologic case study

2000 ◽  
Vol 28 (1) ◽  
Author(s):  
Jerzy Stanek ◽  
Kevin E. Bove ◽  
Mary Bofinger ◽  
Denise Needham ◽  
Luis R. Saldana ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Foramen Ovale ◽  
Vein Thrombosis ◽  
Methylene Tetrahydrofolate Reductase ◽  
Premature Closure ◽  
Reductase Gene ◽  
Methylene Tetrahydrofolate

The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk

2010 ◽  
Vol 38 (2) ◽  
pp. 991-996 ◽  
Author(s):  
Sulhattin Arslan ◽  
Sule Karadayi ◽  
Malik Ejder Yildirim ◽  
Ozturk Ozdemir ◽  
Ibrahim Akkurt
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Lung Cancer Risk ◽  
Methylene Tetrahydrofolate Reductase ◽  
Reductase Gene ◽  
Methylene Tetrahydrofolate

scholarly journals Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications

2010 ◽  
Vol 13 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Olga Filippovna Sibireva ◽  
Ekaterina Yur'evna Khitrinskaya ◽  
Vadim Vital'evich Kalyuzhin ◽  
Aleksey Eduardovich Sazonov ◽  
Igor Ivanovich Ivanchuk ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Prognostic Significance ◽  
Coagulation Factor ◽  
Control Group ◽  
Factor V ◽  
Methylene Tetrahydrofolate Reductase ◽  
Reductase Gene ◽  
Methylene Tetrahydrofolate

Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control group comprised100 healthy subjects. PCR was used to iden-tify single nucleotide substitution (C677T) in the methylene tetrahydrofolate reductase gene (MTHFR),point mutation in coagulation factor V gene (FV), and G202210A mutation in factor II gene (FII). Results. The probability of DN in patients with DM1 increases in the presence of Leiden mutation and in DM2 patients in the presence of single nucleotidesubstitu-tion (C677T) in MTHFR gene and G202210A mutation in the 3-untranslated region of FII. Conclusion. The prevalence of the above mutations associated with blood coagulation potential in DN patients is higher than in healthy subjects.Key words: diabetes mellitus, diabetic nephropathy, gene polymorphism, methylenetetrahydrofolate reductase

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