Peripubertal Prolactinomas: Clinical Presentation and Long-Term Outcome with Different Therapeutic Approaches

2000 ◽  
Vol 13 (3) ◽  
Author(s):  
H.L. Fideleff ◽  
H.R. Boquete ◽  
A. Sequera ◽  
M. Suárez ◽  
P. Sobrado ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Therapeutic Approaches ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort

Rheumatology ◽  
2015 ◽  
Vol 55 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Jan H. Schirmer ◽  
Marvin N. Wright ◽  
Reinhard Vonthein ◽  
Kristine Herrmann ◽  
Bernhard Nölle ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Microscopic Polyangiitis ◽  
Term Outcome ◽  
Long Term Outcome

Renal biopsy in very elderly patients (over 80 years): clinical presentation, histological diagnosis, and long-term outcome

2020 ◽  
Vol 52 (4) ◽  
pp. 721-729
Author(s):  
Martin Planchais ◽  
Benoit Brilland ◽  
Julien Demiselle ◽  
Virginie Besson ◽  
Agnès Duveau ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Renal Biopsy ◽  
Clinical Presentation ◽  
Histological Diagnosis ◽  
Very Elderly ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Does the clinical presentation of atrial fibrillation affect long-term outcome after catheter ablation?

2003 ◽  
Vol 41 (6) ◽  
pp. 94 ◽  
Author(s):  
Nicola Trevisi ◽  
Michela Casella ◽  
Antonio Dello Russo ◽  
Silvia Perlangeli ◽  
Stefania Riva ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Clinical Presentation ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Subacute Thyroiditis: Clinical Presentation and Long Term Outcome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Assim A. Alfadda ◽  
Reem M. Sallam ◽  
Ghadi E. Elawad ◽  
Hisham AlDhukair ◽  
Mossaed M. Alyahya
Keyword(s):  
Clinical Presentation ◽  
Thyroid Stimulating Hormone ◽  
Subacute Thyroiditis ◽  
University Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Thyroid Uptake ◽  
Inflammatory Drugs ◽  
And Gender

Few studies have been reported from the Kingdom of Saudi Arabia (SA) to describe the clinical presentation and long term outcomes of subacute thyroiditis (SAT). Our aim was to review the demographic, anthropometric, clinical presentation, laboratory results, treatment, and disease outcome in Riyadh region and to compare those with results from different regions of the Kingdom and different parts of the world. We reviewed the medical files of patients who underwent thyroid uptake scan during an 8-year period in King Khalid University Hospital. Only 25 patients had confirmed diagnosis of thyroiditis. Age and gender distribution were similar to other studies. Most patients presented with palpitation, goiter, and weight change. Elevated thyroid hormones, suppressed thyroid-stimulating hormone, and elevated ESR were reported. Among those, 7 cases of SAT were recorded.β-Blockers were prescribed to 57% and nonsteroidal anti-inflammatory drugs to 29% of SAT. Long follow-up demonstrated that 85.7% of SAT cases recovered, while 14.3% developed permanent hypothyroidism. In conclusion, SAT is uncommon in the central region of SA. Compared to the western region, corticosteroid is not commonly prescribed, and permanent hypothyroidism is not uncommon. A nation-wide epidemiological study to explain these interprovincial differences is warranted.

scholarly journals Protracted Bacterial Bronchitis, it is a myth?

2021 ◽  
Vol 20 (4) ◽  
Author(s):  
Ahmad Fadzil
Keyword(s):  
Chronic Cough ◽  
Clinical Presentation ◽  
Signs And Symptoms ◽  
Medical Conditions ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Protracted Bacterial Bronchitis

Protracted wet and productive chronic cough is a symptom that indicate there is an underlying cause and the possibility vary from a simple to serious medical conditions. If the cough is accompanied with specific pointers in signs and symptoms, the diagnosis is apparent. Nevertheless, the challenge is to identify the diagnosis in children who cough without specific pointers. Recently, protracted bacterial bronchitis is one of the conditions that was proposed and postulated to conceive this clinical presentation. Since then, the understanding of PBB has escalated and deepened. However, there is still no unanimous consensus in definition, pathophysiology, diagnostic, treatment, long term outcome and even the entity itself. Further research is required to refine understanding of this condition in several facets therefore patients can be treated accordingly.

Functional tricuspid regurgitation of degenerative mitral valve disease: a crucial determinant of survival

2020 ◽  
Vol 41 (20) ◽  
pp. 1918-1929 ◽  
Author(s):  
Benjamin Essayagh ◽  
Clémence Antoine ◽  
Giovanni Benfari ◽  
Joseph Maalouf ◽  
Hector I Michelena ◽  
...  
Keyword(s):  
Tricuspid Regurgitation ◽  
Excess Mortality ◽  
Clinical Presentation ◽  
Systolic Pulmonary Artery Pressure ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Functional Tricuspid Regurgitation ◽  
Valvular Surgery ◽  
Severe Clinical Presentation

Abstract Aims  To assess functional tricuspid regurgitation (FTR) determinants, consequences, and independent impact on outcome in degenerative mitral regurgitation (DMR). Methods and results  All patients diagnosed with isolated DMR 2003–2011, with structurally normal tricuspid leaflets, prospective FTR grading and systolic pulmonary artery pressure (sPAP) estimation by Doppler echocardiography at diagnosis were identified and long-term outcome analysed. The 5083 DMR eligible patients [63 ± 16 years, 47% female, ejection fraction (EF) 63 ± 7%, and sPAP 35 ± 13 mmHg] presented with FTR graded trivial in 45%, mild in 37%, moderate in 15%, and severe in 3%. While pulmonary hypertension (PHTN-sPAP ≥ 50 mmHg) was the most powerful FTR severity determinant, other strong FTR determinants were older age, female sex, lower left ventricle EF, DMR, and particularly atrial fibrillation (AFib) (all P ≤ 0.002). Functional tricuspid regurgitation moderate/severe was independently linked to more severe clinical presentation, more oedema, lower stroke volume, and impaired renal function (P ≤ 0.01). Survival (95% confidence interval) throughout follow-up [70% (69–72%) at 10 years] was strongly associated with FTR severity [82% (80–84%) for trivial, 69% (66–71%) for mild, 51% (47–57%) for moderate, and 26% (19–35%) for severe, P < 0.0001]. Excess mortality persisted after comprehensive adjustment [adjusted hazard ratio 1.40 (1.18–1.67) for moderate FTR and 2.10 (1.63–2.70) for severe FTR, P ≤ 0.01]. Excess mortality persisted adjusting for sPAP/right ventricular function (P < 0.0001), by matching [adjusted hazard ratios 2.08 (1.50–2.89), P < 0.0001] and vs. expected survival [risk ratio 1.79 (1.48–2.16), P < 0.0001]. Within 5-year of diagnosis valve surgery was performed in 73% (70–75%) and 15% (13–17%) of severe and moderate DMR and in only 26% (19–34%) and 6% (4–8%) of severe and moderate FTR. Valvular surgery improved outcome without alleviating completely higher mortality associated with FTR (P < 0.0001). Conclusion  In this large DMR cohort, FTR was frequent and causally, not only linked to PHTN but also to other factors, particularly AFib. Higher FTR severity is associated at diagnosis with more severe clinical presentation. Long term, FTR is independently of all confounders, associated with considerably worse mortality. Functional tricuspid regurgitation moderate and even severe is profoundly undertreated. Thus careful assessment, consideration for tricuspid surgery, and testing of new transcatheter therapy is warranted.

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