scholarly journals Subacute Thyroiditis: Clinical Presentation and Long Term Outcome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Assim A. Alfadda ◽  
Reem M. Sallam ◽  
Ghadi E. Elawad ◽  
Hisham AlDhukair ◽  
Mossaed M. Alyahya
Keyword(s):  
Clinical Presentation ◽  
Thyroid Stimulating Hormone ◽  
Subacute Thyroiditis ◽  
University Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Thyroid Uptake ◽  
Inflammatory Drugs ◽  
And Gender

Few studies have been reported from the Kingdom of Saudi Arabia (SA) to describe the clinical presentation and long term outcomes of subacute thyroiditis (SAT). Our aim was to review the demographic, anthropometric, clinical presentation, laboratory results, treatment, and disease outcome in Riyadh region and to compare those with results from different regions of the Kingdom and different parts of the world. We reviewed the medical files of patients who underwent thyroid uptake scan during an 8-year period in King Khalid University Hospital. Only 25 patients had confirmed diagnosis of thyroiditis. Age and gender distribution were similar to other studies. Most patients presented with palpitation, goiter, and weight change. Elevated thyroid hormones, suppressed thyroid-stimulating hormone, and elevated ESR were reported. Among those, 7 cases of SAT were recorded.β-Blockers were prescribed to 57% and nonsteroidal anti-inflammatory drugs to 29% of SAT. Long follow-up demonstrated that 85.7% of SAT cases recovered, while 14.3% developed permanent hypothyroidism. In conclusion, SAT is uncommon in the central region of SA. Compared to the western region, corticosteroid is not commonly prescribed, and permanent hypothyroidism is not uncommon. A nation-wide epidemiological study to explain these interprovincial differences is warranted.

Axial spondyloarthritis

2013 ◽  
pp. 879-889 ◽  
Author(s):  
Denis Poddubnyy ◽  
Joachim Sieper
Keyword(s):  
Axial Spondyloarthritis ◽  
Axial Skeleton ◽  
Chronic Inflammatory Disease ◽  
Hla B27 ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Male Predominance ◽  
Inflammatory Drugs ◽  
Active Inflammation

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly of the sacroiliac joint (SIJ) and the spine. It starts normally in the second decade of life and has a slight male predominance. The prevalence is between 0.2% and 0.8% and is strongly dependent on the prevalence of HLA-B27 in a given population. AxSpA can be split in patients with radiographic axSpA (also termed ankylosing spondylitis (AS)) and in patients with non-radiographic axSpA (nr-axSpA). For the diagnosis of AS, the presence of radiographic sacroiliitis is mandatory. However, radiographs do not detect active inflammation but only structural bony damage. Most recently new classification criteria for axSpA have been developed by the Assessment of Spondylo-Arthritis International Society (ASAS) which cover AS but also the earlier form of nr-axSpA. MRI has become an important new tool for the detection of subchondral bone marrow inflammation in SIJ and spine and has become increasingly important for an early diagnosis. HLA-B27 plays a central role in the pathogenesis but its exact interaction with the immune system has not yet been clarified. Besides pain and stiffness in the axial skeleton patients suffer also from periods of peripheral arthritis, enthesitis, and uveitis. New bone formation as a reaction to inflammation and subsequent ankylosis of the spine determine long-term outcome in a subgroup of patients. Currently only non-steroidal anti-inflammatory drugs (NSAIDs) and tumour necrosis factor (TNF) blockers have been proven to be effective in the medical treatment of axial SpA, and international ASAS recommendations for the structured management of axial SpA have been published based on these two types of drugs. Conventional disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate are not effective.

Musculoskeletal system

2011 ◽  
pp. 411-414
Author(s):  
Dr Mark Harrison
Keyword(s):  
Musculoskeletal System ◽  
Early Mobilization ◽  
Musculoskeletal Injuries ◽  
Pharmacological Intervention ◽  
Term Outcome ◽  
Long Term Outcome ◽  
System P ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

8.1 Nonpharmacological measures, 412 8.2 Nonsteroidal anti-inflammatory drugs (NSAIDs), 412 8.3 Corticosteroids, 414 8.4 Drugs used in gout and hyperuricaemia, 414 • Management of musculoskeletal injuries and diseases involves more than just pharmacological intervention. • Consideration of splinting, physiotherapy, and early mobilization can be the most effective way to ease pain and improve long-term outcome....

scholarly journals Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Jooyoung Lee ◽  
Su Jin Chung ◽  
Ji Min Choi ◽  
Yoo Min Han ◽  
Joo Sung Kim
Keyword(s):  
Gastric Cancer ◽  
Family History ◽  
University Hospital ◽  
Upper Gastrointestinal Endoscopy ◽  
Clinicopathologic Characteristics ◽  
Term Outcome ◽  
Long Term Outcome ◽  
National University ◽  
Gastric Cancer Patients

Background/Aims. Family history (FHx) has been reported to be a risk factor for gastric cancer (GC). However, the long-term prognosis of GC with FHx remains controversial. We aimed to investigate the clinicopathologic characteristics and long-term outcomes of GC according to the presence or absence of GC FHx. Methods. This study was conducted on asymptomatic healthy individuals who underwent upper gastrointestinal endoscopy for the purpose of GC screening. Patients who were diagnosed with GC between October 2003 and December 2013 at Seoul National University Hospital Healthcare System Gangnam Center were identified. Demographic and clinicopathologic characteristics were compared between the groups with and without FHx of GC. Overall survival (OS) and recurrence-free survival (RFS) were assessed as primary outcomes. Results. There were no significant differences in tumor characteristics according to FHx of GC. However, preexisting adenoma was more frequent in patients with FHx than in those without FHx (14.5% vs. 6.3%, p = 0.035 ). The proportion of patients with microsatellite instability (MSI) was also higher in groups with FHx of GC (43.2% vs. 13.2%, p = 0.006 ). Helicobacter pylori infection rates of patients with FHx of GC tended to be higher although not significant (70.5% vs. 61.3%, p = 0.188 ). However, OS and RFS at 5 years of the GC patients with FHx were not significantly different from those of patients without FHx. Conclusion. Preexisting adenoma and GC with MSI are more common in patients with FHx of GC than in those without. There were no significant differences in the survival rate according to FHx.

scholarly journals Very long-term follow-up of aplastic anemia treated with immunosuppressive therapy or allogeneic hematopoietic cell transplantation

2020 ◽  
Vol 99 (11) ◽  
pp. 2529-2538
Author(s):  
Beatrice Drexler ◽  
Felicitas Zurbriggen ◽  
Tamara Diesch ◽  
Romaine Viollier ◽  
Joerg P. Halter ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Immunosuppressive Therapy ◽  
Hematopoietic Cell Transplantation ◽  
Clonal Evolution ◽  
University Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Long Term Survivors

Abstract Introduction Since the 1970s outcome of aplastic anemia (AA) patients has improved significantly due to the introduction of immunosuppressive therapy (IST) and allogeneic hematopoietic transplantation (HCT). However, patients may suffer from persistent disease, relapse, clonal evolution, graft-versus-host disease and other late effects. Here, we analyse very long-term outcome of all AA patients at our institution comparing not only survival, but also response status and complications. Methods Patient charts of all 302 AA patients treated between 1973 and 2017 at the University Hospital Basel, Switzerland, were retrospectively analysed. Results First line treatment was IST in 226 (75%) and HCT in 76 (25%) patients. Overall survival at 30 years was similar in patients treated initially by HCT and IST (44% (±14%), and 40% (± 9%) respectively, with better results in more recent years. Partial and no response occurred more frequently after IST, relapse incidence after IST was 24 %, whereas non-engraftment and graft failure was documented in 15 patients (19 %) after HCT. Clonal evolution to myelodysplastic syndrome / acute myeloid leukemia was 16 % at 25 years in IST patients, 1.3 % in HCT patients, iron overload (18 versus 4 %, p = 0.002) and cardiovascular events (11 versus 1 %, p=0.011) occured significantly more often in IST than HCT treated patients. The majority of long-term survivors, 96% of those alive at 25 years, were in complete remission at last follow up, irrespective of the initial treatment modality. Conclusion Very long term survivors after AA are those with stable hematopoietic recovery.

scholarly journals Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort

Rheumatology ◽  
2015 ◽  
Vol 55 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Jan H. Schirmer ◽  
Marvin N. Wright ◽  
Reinhard Vonthein ◽  
Kristine Herrmann ◽  
Bernhard Nölle ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Microscopic Polyangiitis ◽  
Term Outcome ◽  
Long Term Outcome

Renal biopsy in very elderly patients (over 80 years): clinical presentation, histological diagnosis, and long-term outcome

2020 ◽  
Vol 52 (4) ◽  
pp. 721-729
Author(s):  
Martin Planchais ◽  
Benoit Brilland ◽  
Julien Demiselle ◽  
Virginie Besson ◽  
Agnès Duveau ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Renal Biopsy ◽  
Clinical Presentation ◽  
Histological Diagnosis ◽  
Very Elderly ◽  
Term Outcome ◽  
Long Term Outcome

Ear injuries caused by lightning: report of 18 cases

2001 ◽  
Vol 115 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Ivo Glunčić ◽  
Željka Roje ◽  
Vicko Glunčić ◽  
Kolja Poljak
Keyword(s):  
Clinical Management ◽  
Neuropsychological Testing ◽  
University Hospital ◽  
Psychotherapeutic Treatment ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Membrane Rupture ◽  
Hearing Function

The clinical management and long-term outcome in lightning survivors with subsctantial ear damage treated at the Department of Otorhinolaryngology, University Hospital Split during the 1984–1999 period are reviewed. Results of clinical management and outcomes of lightning ear damage in 18 patients (mean age 35.3 ± 5 years) were retrospectively analyzed. On admission, all patients complained of severe pain, tinnitus and hearing impairment. Otomicroscopy revealed tympanic membrane rupture in 12 patients. The active therapeutic approach included immediate otomicroscopy, aseptic aspiration toilet, and eversion of perforation edges. In all patients, the ruptures healed well, and restitution of the hearing function was achieved. Follow-up examination performed in 1999 (13.2 ± 2.9 years later) in 11 patients (mean age 52.3 ± 6.1 years) revealed an almost identical audiogram as on discharge from the hospital, however, neuropsychological testing revealed numerous sequelae. Tympanic injury caused by lightning should be actively treated. Lightning survivors require additional psychotherapeutic treatment.

scholarly journals Does the clinical presentation of atrial fibrillation affect long-term outcome after catheter ablation?

2003 ◽  
Vol 41 (6) ◽  
pp. 94 ◽  
Author(s):  
Nicola Trevisi ◽  
Michela Casella ◽  
Antonio Dello Russo ◽  
Silvia Perlangeli ◽  
Stefania Riva ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Clinical Presentation ◽  
Term Outcome ◽  
Long Term Outcome
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