Leitlinien-Update 061/017 In-vitro-Allergiediagnostik 1 , 2 / In-vitro allergy diagnostics Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI), Ärzteverband deutscher Allergologen (ÄDA), Gesellschaft für pädiatrische Allergologie (GPA), Deutsche Dermatologische Gesellschaft (DDG)

2010 ◽  
Vol 34 (4) ◽  
pp. 177-195
Author(s):  
Harald Renz ◽  
Thomas Biedermann ◽  
Albrecht Bufe ◽  
Bernadette Eberlein ◽  
Uta Jappe ◽  
...  
Keyword(s):  
Deutsche Gesellschaft ◽  
Allergy Diagnostics

The risk of sensitization to furry animals in patients already sensitized to cat/dog: An in vitro evaluation using molecular-based allergy diagnostics

2015 ◽  
Vol 135 (6) ◽  
pp. 1664-1666 ◽  
Author(s):  
Gennaro Liccardi ◽  
Antonio Meriggi ◽  
Maria Russo ◽  
Stefania Croce ◽  
Antonello Salzillo ◽  
...  
Keyword(s):  
In Vitro Evaluation ◽  
Allergy Diagnostics

Development of hydrogel biochip for in vitro allergy diagnostics

2014 ◽  
Vol 406 ◽  
pp. 51-57 ◽  
Author(s):  
G.U. Feyzkhanova ◽  
M.A. Filippova ◽  
V.O. Talibov ◽  
E.I. Dementieva ◽  
V.V. Maslennikov ◽  
...  
Keyword(s):  
Allergy Diagnostics

scholarly journals The problem of hypersensitivity to vitamin preparations

2021 ◽  
pp. 30-39
Author(s):  
S.V. Zaikov ◽  
G.L. Gumeniuk ◽  
L.V. Veselovsky
Keyword(s):  
Adverse Reactions ◽  
Evidence Base ◽  
B Vitamins ◽  
Medicinal Products ◽  
Scientific Publications ◽  
Allergy Diagnostics ◽  
History Of ◽  
Inflammatory Drugs

ABSTRACT. The problem of the development of adverse reactions as a result of the use of diagnostic and medicinal products (drugs) is becoming increasingly important. Patients more often report reactions to local anesthetics (43.2 % of cases), antibiotics (18.8 %), nonsteroidal anti-inflammatory drugs (9.7 %), other drugs (28.4 %), B vitamins (4-5 %). It is important to understand that hypersensitivity (HS) to vitamin preparations (VP) is very common, according to patients, but not so often confirmed by their in-depth allergy examination. Basic data on HS before the VP were obtained in the 80-90s of the 20th century, but since then the situation has changed radically. The frequency of HS on these drugs is based on medical history when patients use multicomponent VP for oral administration, allergens in which may be other components (shell tablets and capsules, metal salts, flavors, sweeteners, dyes, preservatives). The causative allergens in the injectable forms of VP can also be auxiliary ingredients of the drug, in particular lidocaine and benzyl alcohol. There are only a few scientific publications with the appropriate evidence base for HS to individual VP, more often B vitamins. The clinical picture of HS reactions to VP is diverse (systemic, cutaneous, respiratory, rarely other visceral manifestations). They can develop both immediately and in a delayed type. Part of the VP (B vitamins, vitamin K) can cause the development of anaphylaxis with fatal consequences. VP, as a rule, do not belong to vital drugs therefore it is possible for this reason till now in real clinical practice insufficiently developed methods of allergodiagnostics both in vivo (skin, provocative tests), and in vitro (laboratory tests) among patients with suspicion for the development of HS to VP. It is not possible to perform allergy diagnostics in persons who have taken complex VP, so there is a problem of hyperdiagnosis of drug allergy to them. Therefore, the problem of determining the true allergic reaction in patients who report the development of a history of HS to VP remains relevant. As a rule, after the development of any adverse reaction during the reception of VP on the patient hangs the label “allergy to vitamins” for life without further allergy examination. That is why the problem of HS to VP needs further study.

Six years of INSTAND e. V. sIgE proficiency testing: an evaluation of in vitro allergy diagnostics

2017 ◽  
Vol 26 (2) ◽  
pp. 20-29
Author(s):  
Nathalie Wojtalewicz ◽  
Sabine Goseberg ◽  
Kathrin Kabrodt ◽  
Ingo Schellenberg
Keyword(s):  
Proficiency Testing ◽  
Allergy Diagnostics

scholarly journals A Proof-of-Concept of Label-Free Biosensing System for Food Allergy Diagnostics in Biophotonic Sensing Cells: Performance Comparison with ImmunoCAP

Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2686 ◽  
Author(s):  
Rocio Espinosa ◽  
María Laguna ◽  
Fátima Fernández ◽  
Beatriz Santamaria ◽  
Francisco Sanza ◽  
...  
Keyword(s):  
Food Allergy ◽  
Performance Comparison ◽  
Common Disease ◽  
In Vitro Test ◽  
Label Free ◽  
Children And Young People ◽  
Allergy Diagnostics ◽  
Vitro Test ◽  
Biosensing System

Food allergy is a common disease worldwide with over 6% of the population (200–250 million people) suffering from any food allergy nowadays. The most dramatic increase seems to be happening in children and young people. Therefore, improvements in the diagnosis efficiency of these diseases are needed. Immunoglobulin type E (IgE) biomarker determination in human serum is a typical in vitro test for allergy identification. In this work, we used a novel biosensor based on label-free photonic transducers called BICELLs (Biophotonic Sensing Cells) for IgE detection. These BICELLs have a thin film of nitrocellulose over the sensing surface, they can be vertical optically interrogated, and are suitable for being integrated on a chip. The BICELLs sensing surface sizes used were 100 and 800 µm in diameter. We obtained calibration curves with IgE standards by immobilizating anti-IgE antibodies and identified with standard IgE calibrators in minute sample amounts (3 µL). The results, in similar assay format, were compared with commercially available ImmunoCAP®. The versatility of the interferometric nitrocellulose-based sensing surface was demonstrated since the limit of detections for BICELLs and ImmunoCAP® were 0.7 and 0.35 kU/L, respectively.

In-vitro allergy diagnostics

2016 ◽  
Vol 39 (4) ◽  
Author(s):  
Harald Renz
Keyword(s):  
Specific Immunotherapy ◽  
Therapeutic Strategies ◽  
Food Allergies ◽  
Differential Diagnostics ◽  
Diagnostic Tools ◽  
Allergen Components ◽  
Recent Developments ◽  
Allergy Diagnostics ◽  
Cellular Diagnostics

AbstractIn vitro allergy diagnostics is rapidly advancing. This is primarily due to the development of component-based diagnostic tools. The availability of allergen components now allows a more precise and patient-tailored diagnostics, which has implications for therapeutic strategies including decision about specific immunotherapy. Furthermore, differential diagnostics of food intolerances and food allergies is also advancing because of this novel test. Another area of advancement is cellular diagnostics, which is primarily based on basophile activation tests. These recent developments will be discussed in this article.

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