scholarly journals Vitamin B12 absorption judged by measurement of holotranscobalamin, active vitamin B12: evaluation of a commercially available EIA kit

2011 ◽  
Vol 49 (11) ◽  
Author(s):  
Eva Greibe ◽  
Ebba Nexo
Keyword(s):  
Vitamin B12 ◽  
Active Vitamin ◽  
Vitamin B12 Absorption

scholarly journals Holo-Transcobalamin Concentration and Transcobalamin Saturation Reflect Recent Vitamin B12 Absorption Better than Does Serum Vitamin B12

2004 ◽  
Vol 50 (6) ◽  
pp. 1043-1049 ◽  
Author(s):  
Mustafa Vakur Bor ◽  
Ebba Nexø ◽  
Anne-Mette Hvas
Keyword(s):  
Vitamin B12 ◽  
Serum Vitamin ◽  
Healthy Individuals ◽  
Active Vitamin ◽  
Intraindividual Variation ◽  
Blood Samples ◽  
Normal Vitamin ◽  
Vitamin B12 Absorption ◽  
Age Range ◽  
Better Than

Abstract Background: We evaluated whether measurement of vitamin B12-saturated transcobalamin (holo-TC) concentrations or TC saturation (holo-TC:total TC) reflects active vitamin B12 absorption in healthy individuals and patients after vitamin B12 intake. Methods: We obtained blood samples from 31 healthy individuals (age range, 25–57 years) before (days −1 and 0) and after (days 1, 2, and 6) oral administration of three 9-μg doses of vitamin B12. The blood samples from seven patients (age range, 22–39 years) suspected to have decreased vitamin B12 absorption were obtained before and 1 day after the vitamin B12 intake. The blood samples were analyzed for vitamin B12, total TC, and holo-TC. The TC saturation was calculated. Results: Intraindividual variation was <13% for all measured values, as calculated from samples removed on day −1 and 0. In healthy individuals (n = 31) after intake of vitamin B12, the maximum median (range) increase (as percentages and absolute values) was in TC saturation [52 (−2% to 128)% and 0.04 (0–0.23) as a fraction], closely followed by holo-TC concentrations [39 (0–108)% and 34 (0–149) pmol/L]. All but one healthy individual had an increase of ≥15% in these markers. Serum vitamin B12 showed a smaller increase [14 (−8 to 51)% and 36 (−27 to 290) pmol/L]. After vitamin B12 intake, three patients with Crohn disease had the lowest increases in holo-TC concentration (3, 7, and 14 pmol/L) and in TC saturation (0.004, 0.01, and 0.01) among patients and 30 healthy individuals. Conclusion: Holo-TC concentrations and TC saturation reflect normal vitamin B12 absorption better than does serum vitamin B12.

scholarly journals In situproduction of active vitamin B12 in cereal matrices usingPropionibacterium freudenreichii

2017 ◽  
Vol 6 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Bhawani Chamlagain ◽  
Tessa A. Sugito ◽  
Paulina Deptula ◽  
Minnamari Edelmann ◽  
Susanna Kariluoto ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Active Vitamin

scholarly journals The response to prednisolone in atrophic gastritis: a possible effect on non-intrinsic factor-mediated vitamin B12 absorption

Gut ◽  
1973 ◽  
Vol 14 (1) ◽  
pp. 13-19 ◽  
Author(s):  
R. G. Strickland ◽  
J. M. Fisher ◽  
K. Lewin ◽  
K. B. Taylor
Keyword(s):  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Intrinsic Factor ◽  
Vitamin B12 Absorption

Vitamin B12 Absorption

1958 ◽  
Vol 6 (3) ◽  
pp. 332-333 ◽  
Author(s):  
ROBERT F. SCHILLING
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Absorption

scholarly journals Vitamin B12 Malabsorption Due to Intrinsic Factor Deficiency in Indian Subjects

Blood ◽  
1972 ◽  
Vol 40 (5) ◽  
pp. 747-753 ◽  
Author(s):  
H. G. Desai ◽  
F. P. Antia
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Indian Population ◽  
Intrinsic Factor ◽  
Subacute Combined Degeneration ◽  
Factor Deficiency ◽  
Vitamin B12 Absorption ◽  
Intrinsic Factor Deficiency ◽  
Intrinsic Factor Antibody ◽  
Vitamin B12 Malabsorption

Abstract Sixteen patients (from Bombay) with severe vitamin B12 malabsorption due to intrinsic factor deficiency, presenting as subacute combined degeneration of the cord (7), tropical sprue (3), anemia (2), thyrotoxicosis (2), diabetes mellitus (1), and pain in the abdomen (1), are reported. The difficulties of establishing a definite diagnosis of pernicious anemia in Indian population are described. The lower incidence of circulating intrinsic factor antibody (IFA) in Indian patients with histamine-fast achlorhydria and poor vitamin B12 absorption is emphasized. The necessity of separating atrophic gastritis, with severely impaired vitamm B12 absorption, from pernicious anemia on the basis of absence or presence of IFA in serum and/or gastric juice cannot be overemphasized.

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