Analytical performance of the Albumin Cobalt Binding (ACB®) test on the Cobas MIRA® Plus analyzer

2004 ◽  
Vol 42 (4) ◽  
Author(s):  
Stéphane Gidenne ◽  
Franck Ceppa ◽  
Eleonore Fontan ◽  
Françoise Perrier ◽  
Pascal Burnat
Keyword(s):  
Biological Marker ◽  
Analytical Performance ◽  
Ischemia Modified Albumin ◽  
Cobalt Binding

AbstractRecently a new biological marker, Ischemia Modified Albumin (IMA

scholarly journals Ischemia-Modified Albumin As a Marker for Acute Aortic Dissection: A Prospective Observational Study

2021 ◽  
Author(s):  
Yang zhou ◽  
Xiangping Chai ◽  
Huaping He ◽  
Wen Peng ◽  
Guifang Yang ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Prospective Observational Study ◽  
Acute Aortic Dissection ◽  
Area Under The Curve ◽  
Cost Effective ◽  
Final Diagnosis ◽  
Net Benefit ◽  
Ischemia Modified Albumin ◽  
Potential Biomarker ◽  
Cobalt Binding

Abstract Background: Delayed or misdiagnosed aortic dissection can lead to death and morbidity. Ischemia-modified albumin (IMA) measures the cobalt binding capability and has been associated with mortality in patients with acute aortic dissection (AAD). However, it is unknown whether IMA levels can differentiate AAD in patients with chest pains.Methods: A total of 100 suspected AAD patients were enrolled in this study. A cobalt-binding assay was used to determine the plasma IMA levels. In addition, the IMA levels of patients in different groups were compared based on the final diagnosis. Results: IMA levels were significantly higher in the AAD group than in the AMI, PE, and other groups (63.98 ± 14.38, 52.57 ± 9.54, 49.26 ± 10.99, 37.99 ± 6.59, respectively) within 24 hours after the onset of symptoms. The area under the curve (AUC) based on the IMA level was 0.810 (95% CI, 0.708–0.897), and the best threshold of IMA was 59.35 u/ml (specificity, 85.7% and sensitivity, 66%). The decision and clinical impact curves indicated that the IMA had an excellent standardized net benefit and could be suitable for patient diagnosis.Conclusion: IMA is elevated in AAD patients. The IMA levels have better performance for AAD than D-dimer and could be a potential biomarker with rapid and cost-effective diagnostic tests for early diagnosis of AAD. However, large-sample studies are needed to verify the findings.

High-workload endurance training may increase serum ischemia-modified albumin concentrations

2005 ◽  
Vol 43 (7) ◽  
Author(s):  
Giuseppe Lippi ◽  
Giorgio Brocco ◽  
Gian Luca Salvagno ◽  
Martina Montagnana ◽  
Francesco Dima ◽  
...  
Keyword(s):  
Endurance Training ◽  
Myocardial Injury ◽  
Troponin T ◽  
Acute Chest Pain ◽  
Medium Term ◽  
Ischemia Modified Albumin ◽  
Coronary Syndrome ◽  
High Workload ◽  
Cobalt Binding ◽  
Creatine Kinase Isoenzyme Mb

AbstractThe measurement of cardiac troponins has emerged as the biochemical “gold standard” for the diagnosis and management of patients with acute chest pain. However, earlier markers should support investigation strategies, as several patients with acute coronary syndrome might present with non-diagnostic concentrations. Ischemia-modified albumin (IMA), measured by the albumin cobalt binding (ACB) assay, was recently proposed for early detection of myocardial ischemia. To establish the potential influence of endurance training on the diagnostic approach to patients with suspected myocardial injury, cardiac troponin T (cTnT), creatine kinase isoenzyme MB (CK-MB), myoglobin and IMA were evaluated in healthy individuals subjected to different aerobic workloads. The concentrations of both IMA and CK-MB were significantly increased in athletes subjected to high-workload endurance training, whereas the concentration of cTnT and myoglobin was not influenced by physical exercise in the medium term. Taken together, our results demonstrate that demanding aerobic physical activity might influence the generation of IMA, which might be increased in the medium term following high-workload endurance training, while the concentration of other conventional markers of myocardial injury remains non-diagnostic.

scholarly journals Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia

2019 ◽  
Vol 43 (5) ◽  
pp. 257-263
Author(s):  
Sule Arican ◽  
Gulcin Hacibeyoglu ◽  
Sinan Oguzhan Ulukaya ◽  
Gamze Avcioglu ◽  
Ruhiye Reisli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Postherpetic Neuralgia ◽  
Defense Mechanisms ◽  
Healthy Controls ◽  
Control Groups ◽  
Ischemia Modified Albumin ◽  
Total Thiol ◽  
Cobalt Binding ◽  
And Control ◽  
Plasma Thiols

Abstract Background Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results Serum IMA levels were 1.21 ± 0.58 AU and 0.75 ± 0.09 AU in the PHN and control groups, respectively (p < 0.001). Serum total thiol concentrations were found to be 421.62 ± 90.28 μmol/L and 598.36 ± 73.63 μmol/L in the PHN and control groups, respectively (p < 0.001). Serum native thiol concentrations were found to be 365.75 ± 92.07 μmol/L and 531.90 ± 72.9 μmol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 ± 5.33 μmol/L and 27.93 ± 7.81 μmol/L in the PHN and control groups, respectively (p = 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.

scholarly journals Ischemia-Modified Albumin As A Marker For Acute Aortic Dissection: A Prospective Observational Study

2021 ◽  
Author(s):  
Yang zhou ◽  
Xiangping Chai ◽  
Huaping He ◽  
Wen Peng ◽  
Guifang Yang ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Prospective Observational Study ◽  
Acute Aortic Dissection ◽  
Area Under The Curve ◽  
Cost Effective ◽  
Final Diagnosis ◽  
Net Benefit ◽  
Ischemia Modified Albumin ◽  
Potential Biomarker ◽  
Cobalt Binding

Abstract Background: Delayed or misdiagnosed aortic dissection can lead to death and morbidity. Ischemia-modified albumin (IMA) measures the cobalt binding capability and has been associated with mortality in patients with acute aortic dissection (AAD). However, it is unknown whether IMA levels can differentiate AAD in patients with chest pains.Methods: A total of 100 suspected AAD patients were enrolled in this study. A cobalt-binding assay was used to determine the plasma IMA levels. In addition, the IMA levels of patients in different groups were compared based on the final diagnosis. Results: IMA levels were significantly higher in the AAD group than in the AMI, PE, and other groups (63.98 ± 14.38, 52.57 ± 9.54, 49.26 ± 10.99, 37.99 ± 6.59, respectively) within 24 hours after the onset of symptoms. The area under the curve (AUC) based on the IMA level was 0.810 (95% CI, 0.708–0.897), and the best threshold of IMA was 59.35 u/ml (specificity, 85.7% and sensitivity, 66%). The decision and clinical impact curves indicated that the IMA had an excellent standardized net benefit and could be suitable for patient diagnosis.Conclusion: IMA is elevated in AAD patients. The IMA levels have better performance for AAD than D-dimer and could be a potential biomarker with rapid and cost-effective diagnostic tests for early diagnosis of AAD. However, large-sample studies are needed to verify the findings.

scholarly journals Assessment of serum Ischemia Modified Albumin (IMA) Levels in Acute Rheumatic Fever

2020 ◽  
Vol 5 (2) ◽  
pp. 222
Author(s):  
Indranil Dawn ◽  
Gouranga Biswas
Keyword(s):  
Oxidative Stress ◽  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Control Group ◽  
P Value ◽  
Acute Phase Reactants ◽  
Ischemia Modified Albumin ◽  
Medical College ◽  
Reactive Protein ◽  
Cobalt Binding

Introduction : Rheumatic fever (RF) is an autoimmune, multiorgan inflammatory disease. The patients develop carditis (50-78%), arthritis (35-88%), chorea (2-19%), erythema marginatum (< 6%) and subcutaneous nodules (< 1-13%). Ischemia modified albumin or cobalt binding albumin is one of new biomarker for inflammation and oxidative stress. Various previous studies indicate that acute rheumatic fever is associated with oxidative stress and inflammation. In the present study, we examined IMA, CRP, ESR and albumin levels in acute rheumatic fever.Material and method: This case control study was conductedbetween April 2017 to March 2018 in pediatrics department of Malda Medical College and Hospital. Study group composed of 42 children aged 5-18 years suffering from acute rheumatic fever diagnosed by modified jones criteria and they compared with 50 healthy age and sex match control. The IMA levels were compared among groups, and the association to acute phase reactants were investigated.Results: Values ofserumischemia modified albumin, ESR and C Reactive Protein were significantly higher in cases compared to control group (p value ≤0.001). But no significant differencewas found between values of serum albumin in cases compared to control group. Positive correlation was found between cases serum IMA and ESR, C-Reactive protein.Conclusion: Serumischemia modified albumin were significantly higher in children with acute rheumatic fever compared to control group, so IMA could be used as a biomarker in diagnosis of ARF. However, further multicenter and larger case studies are needed to provide stronger evidence.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 222-225

Albumin cobalt binding and ischemia modified albumin generation: An endogenous response to ischemia?

2006 ◽  
Vol 108 (3) ◽  
pp. 410-411 ◽  
Author(s):  
Giuseppe Lippi ◽  
Martina Montagnana ◽  
Gian Cesare Guidi
Keyword(s):  
Ischemia Modified Albumin ◽  
Cobalt Binding

scholarly journals Ischemia-Modified Albumin: Origins and Clinical Implications

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Alla Shevtsova ◽  
Iuliia Gordiienko ◽  
Viktoriia Tkachenko ◽  
Galyna Ushakova
Keyword(s):  
Oxidative Stress ◽  
Metal Binding ◽  
Plasma Proteins ◽  
Binding Capacity ◽  
Clinical Analysis ◽  
The Body ◽  
Multifunctional Protein ◽  
Ischemia Modified Albumin ◽  
Cobalt Binding ◽  
Generation Mechanisms

Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

scholarly journals Lack of significant difference between internal spermatic vein and brachial vein ischemia modified albumin levels in patients with varicocele

2013 ◽  
Vol 85 (1) ◽  
pp. 34
Author(s):  
Yuksel Aliyazicioglu ◽  
Emin Ozbek ◽  
Levent Ozcan ◽  
S. Sami Cakir ◽  
Murat Dursun
Keyword(s):  
Male Infertility ◽  
Molecular Mechanisms ◽  
Spermatic Vein ◽  
Male Factor ◽  
Ischemia Modified Albumin ◽  
Testicular Dysfunction ◽  
Internal Spermatic Vein ◽  
Significant Difference ◽  
Cobalt Binding ◽  
Brachial Vein

Varicocele is the most common and surgically correctible cause of male infertility in men attending to infertility clinics. Infertility affects 15% of all couples and male factor is the primary or contributing cause in 40% to 60% of cases. Varicocele has been shown to cause male infertility in about 15% of infertile couples. Molecular mechanisms responsible from varicocele induced testicular dysfunction and male infertility have not been completely unknown. Recent years have witnessed a huge amount of scientific works devoted to the mechanism of varicocele associated male infertility and rapid progress in research on its cellular and molecular mechanisms, including apoptosis and oxidative stress of germ cells. Here we evaluated internal spermatic vein and brachal vein ischemia modified albumin (IMA) level in 40 adult male patients with varicocele. IMA level was analyzed using albumin cobalt-binding test. Spermatic vein and brachial vein IMA levels were 0.381 &plusmn; 0.135 ABSU (absorbance units) and 0.385 &plusmn; 0.131 ABSU, respectively. There was no statistically significant difference between the two areas. IMA levels in the internal spermatic vein of patients with varicocele should not be used as a marker of hypoxia.

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