Evaluation of Denka-Seiken Turbidimetric High-Sensitivity C-Reactive Protein Assay

2002 ◽  
Vol 40 (8) ◽  
Author(s):  
Hyun Ju Sung ◽  
Jeong-Ho Kim ◽  
Rojin Park ◽  
Kyung Ryul Lee ◽  
Oh Hun Kwon
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Protein Assay ◽  
Reactive Protein

scholarly journals Validation and application of a canine-specific automated high-sensitivity C-reactive protein assay

2015 ◽  
Vol 27 (2) ◽  
pp. 182-190 ◽  
Author(s):  
Anna Hillström ◽  
Ragnvi Hagman ◽  
Josefin Söder ◽  
Jens Häggström ◽  
Ingrid Ljungvall ◽  
...  
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Protein Assay ◽  
Reactive Protein

scholarly journals Evaluation of high sensitivity C-reactive protein assay in cerebrospinal fluid on the Dimension RxL analyzer

2012 ◽  
Vol 2 (1) ◽  
pp. 13-16
Author(s):  
Jozo Ćorić ◽  
Aleksandra Pašić ◽  
Mirsad Panjeta ◽  
Jasminka Mujić
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
High Sensitivity ◽  
Acute Bacterial Meningitis ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Assay ◽  
Reactive Protein ◽  
The Mean ◽  
Low Sensitivity

Introduction: Low sensitivity and specificity in traditional laboratory tests became insufficient for accurate diagnostics and initiation of proper treatment of patients infected with bacterial meningitis. High sensitivity C reactive protein (hsCRP) may be an appropriate supplement for rapid diagnosis of bacterial meningitis. The subject of our investigation was the determination of C- reactive protein in cerebrospinal fluid (CSF) duringacute bacterial meningitis.Methods: HsCRP was analysed by a sensitive immunoturbidimetric assay using the Dimension RxL analyser (Siemens). Cerebrospinal fluid concentrations of C-reactive protein have been measured in 20 patients(age range,1 to 50 years) presenting with acute bacterial meningitis and also in a non-infected, non-inflamed control group (n=25).Results: The accuracy and precision of the method proved to be satisfactory. Repeatability of serial sampling for hsCRP described by coefficient of variation were CV=2.1-4.5%. This assay hsCRP in cerebrospinal fluid demonstrates adequate performance characteristics for routine clinical use. Elevated levels of CRP were found in 95% patients with bacterial meningitis. The mean CRP value in 25 uninfected control group was 0.25 mg/L (range 0.10-0.55). The mean CRP for patients with bacterial meningitis was 21.4 mg/L (range 0.40-100).Conclusions: A sensitive assay for CRP in CSF would be an useful adjunct to conventional investigation of acute infective meningitis.

scholarly journals Clinical Efficacy of an Automated High-Sensitivity C-Reactive Protein Assay

1999 ◽  
Vol 45 (12) ◽  
pp. 2136-2141 ◽  
Author(s):  
Nader Rifai ◽  
Russell P Tracy ◽  
Paul M Ridker
Keyword(s):  
Confidence Interval ◽  
Clinical Efficacy ◽  
Prospective Studies ◽  
Smoking Habit ◽  
High Sensitivity ◽  
Case Group ◽  
C Reactive Protein ◽  
Protein Assay ◽  
Reactive Protein ◽  
Hs Crp

Abstract Background: Prospective studies have shown that C-reactive protein (CRP) can be used to predict risk of future cardiovascular events. High-sensitivity methods for CRP (hs-CRP) measurement are needed for this purpose. Methods: We compared the clinical efficacy of an automated and commercially available latex-enhanced assay (Latex) for hs-CRP (Dade Behring) to a validated in-house ELISA, previously shown to predict future peripheral arterial disease (PAD) in asymptomatic populations. Using a prospective, nested, case-control design, we measured baseline hs-CRP concentrations in 144 apparently healthy men who subsequently developed symptomatic PAD and 144 age- and smoking habit-matched controls who remained free of vascular disease over the follow-up period of 60 months. Results: The two hs-CRP assays correlated highly (r = 0.95; P <0.001), and all but two participants were classified into concordant quartiles or varied by only one quartile. The median hs-CRP of the case group was significantly higher than that of controls when measured by either the ELISA (1.34 vs 0.99 mg/L; P = 0.034) or the Latex method (1.80 vs 1.20 mg/L; P = 0.042). Furthermore, for both ELISA and the Latex method, the calculated relative risks of developing PAD increased significantly with each increasing quartile of hs-CRP. The calculated interquartile increase in relative risk of PAD was 31% (95% confidence interval, 5.2–62.2%; P = 0.01) for ELISA and 34% (95% confidence interval, 8.2–66.1%; P = 0.007) for the Latex method. Conclusions: Our findings indicate that the Latex method is equally as efficacious as the validated ELISA in classifying patients into cutoff points established by prospective studies for risk stratification for coronary and cerebrovascular disease.

Role of high sensitivity C - Reactive protein and some of heavy metals in patients with rheumatoid arthritis

2020 ◽  
Vol 23 (16) ◽  
Author(s):  
Nashwan S. Albabawaty ◽  
Ali Y. Majid ◽  
Mohammed H. Alosami ◽  
Halla G. Mahmood
Keyword(s):  
Rheumatoid Arthritis ◽  
Heavy Metals ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

High Sensitivity C-Reactive Protein as a Potential Biomarker of Neuroinflammation in Major Psychiatric Disorders

2018 ◽  
Vol 14 (2) ◽  
pp. 105-128
Author(s):  
Giordano Padovan ◽  
Rosa Preteroti ◽  
Beatrice Bortolato ◽  
Maria Magdalini Papaioannou ◽  
Giada Piva ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Potential Biomarker
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