scholarly journals Inhibitory effect of calcium channel blockers on .ALPHA.-adrenergic activation of glycogenolysis and calcium efflux in perfused rat liver.

1981 ◽  
Vol 28 (1) ◽  
pp. 69-78 ◽  
Author(s):  
SATOSHI KIMURA ◽  
YOSHINOBU KOIDE ◽  
RYOKO TADA ◽  
KAORU ABE ◽  
ETSURO OGATA
Keyword(s):  
Calcium Channel ◽  
Rat Liver ◽  
Calcium Channel Blockers ◽  
Inhibitory Effect ◽  
Channel Blockers ◽  
Perfused Rat Liver ◽  
Calcium Efflux ◽  
Adrenergic Activation

Inhibition by calcium channel blockers of the glycogenolytic effect of glucagon in perfused rat liver

1982 ◽  
Vol 99 (4) ◽  
pp. 559-566 ◽  
Author(s):  
Satoshi Kimura ◽  
Toshio Matsumoto ◽  
Ryoko Tada ◽  
Etsuro Ogata ◽  
Kaoru Abe
Keyword(s):  
Cyclic Amp ◽  
Calcium Channel ◽  
Rat Liver ◽  
Calcium Channel Blockers ◽  
Calcium Influx ◽  
Extracellular Calcium ◽  
Channel Blockers ◽  
Perfused Rat Liver ◽  
Glycogenolytic Effect ◽  
Glucose Output

Abstract. Verapamil and diltiazem, calcium channel blockers, inhibited significantly the glucagon-induced glucose output and 45Ca efflux from perfused rat liver at concentrations higher than 50 μm when the perfusate contained calcium. Although the blockers partially interfered with glucagon-induced elevation of cyclic AMP in the tissue, they also inhibited the effects of cyclic AMP. The blockers did not show the inhibitory effects in the absence of perfusate calcium. However, the inhibition of calcium influx into hepatocytes by omission of extracellular calcium or addition of EGTA did not interfere with these effects of glucagon and cyclic AMP. In the presence of extracellular calcium, the blockers did not inhibit cyanide-induced glucose output, indicating that the activity of glycogen phosphorylase and later processes leading to glucose output were not affected by the blockers. These data suggest that, in the presence of calcium, the blockers inhibit the effect of glucagon also at a step (or steps) subsequent to cyclic AMP production and before the activation of phosphorylase b, probably by inhibiting glucagon-induced mobilization of calcium from intracellular calcium pools rather than inhibiting calcium influx into hepatocytes.

Inhibitory Effect of Calcium Channel Blockers on Growth of Pancreatic Cancer Cells

Pancreas ◽  
1994 ◽  
Vol 9 (2) ◽  
pp. 193-202 ◽  
Author(s):  
Kazuo Sato ◽  
Jin Ishizuka ◽  
Cary W. Cooper ◽  
Dai H. Chung ◽  
Takashi Tsuchiya ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Calcium Channel ◽  
Cancer Cells ◽  
Calcium Channel Blockers ◽  
Inhibitory Effect ◽  
Channel Blockers ◽  
Pancreatic Cancer Cells

scholarly journals CYP3A4 Genetic Status May Be Associated With Increased Vulnerability to the Inhibitory Effect of Calcium-Channel Blockers on Clopidogrel

2013 ◽  
Vol 77 (5) ◽  
pp. 1289-1296 ◽  
Author(s):  
Jin Joo Park ◽  
Kyung Woo Park ◽  
Jeehoon Kang ◽  
Ki-Hyun Jeon ◽  
Si-Hyuck Kang ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Inhibitory Effect ◽  
Channel Blockers ◽  
Genetic Status

Inhibitory effect of calcium channel blockers on proliferation of human glioma cellsin vitro

1989 ◽  
Vol 79 (2) ◽  
pp. 166-169 ◽  
Author(s):  
J. Kunert-Radek ◽  
H. Stepien ◽  
A. Radek ◽  
K. Lyson ◽  
M. Pawlikowski
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Inhibitory Effect ◽  
Channel Blockers ◽  
Human Glioma
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