Protective effect of vitamin D3 on methylprednisolone acetate (MPA) induced loss of bone metabolism markers and bone mineral density in the lumbar spine of rat

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 19
Author(s):  
A. Sobhani ◽  
F. Moradi ◽  
P. Pasbakhsh ◽  
I.R. Kashani
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Protective Effect ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Methylprednisolone Acetate ◽  
Mineral Density ◽  
Bone Metabolism Markers

Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine

2004 ◽  
Vol 43 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Katsuhiko Yonemura ◽  
Hirotaka Fukasawa ◽  
Yoshihide Fujigaki ◽  
Akira Hishida
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Protective Effect ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Bone mineral density and its influencing factors in Chinese children with spinal muscular atrophy types 2 and 3

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaoyin Peng ◽  
Yujin Qu ◽  
Xiaohui Li ◽  
Junting Liu ◽  
Xinying Shan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Spinal Muscular Atrophy ◽  
Bone Metabolism ◽  
Influencing Factors ◽  
Bone Mineral ◽  
Muscular Atrophy ◽  
Mineral Density ◽  
Bone Metabolism Markers ◽  
Z Scores ◽  
Serum Pth

Abstract Background Patients with spinal muscular atrophy (SMA) are at risk of decreased bone mineral density (BMD). The bone health status of Chinese patients with SMA has been poorly studied. We aimed to evaluate the BMD of children with SMA types 2 and 3 in mainland China and investigate its influencing factors. Methods Forty patients with a mean age of 5.5 years affected by SMA types 2 and 3 (n = 22 and n = 18, respectively) were enrolled between September 2017 and May 2019. Total body less head (TBLH) BMD, lumbar spine (LS) BMD, and body composition were measured using dual-energy X-ray absorptiometry (DXA). Serum bone metabolism markers and complete spinal radiographs were assessed. We utilized a linear regression model to explore the correlations between BMD and its related factors. Results A total of 67.5% (27/40) of patients were diagnosed with low BMD and 2.5% (1/40) were diagnosed with osteoporosis. The TBLH BMD and LS BMD Z-scores in children with SMA type 2 were significantly lower than those with SMA type 3. Both TBLH and LS BMD Z-scores tended to increase with the change of SMA subtypes from 2a-3b. Vitamin D insufficiency and deficiency were found in 37.5% (15/40) of the patients. Serum Ca, phosphorus (P), alkaline phosphatase (ALP) and parathormone (PTH) levels were normal. There were no significant differences among the four subtypes in terms of all the serum bone metabolism markers. Phenotype was significantly associated with TBLH BMD and LS BMD Z-scores, and serum PTH levels were significantly associated with TBLH BMD Z-scores. Conclusions Low BMD and osteoporosis were highly prevalent in mainland Chinese children with SMA types 2 and 3. Phenotype and serum PTH level might be the influencing factors of BMD. Regular monitoring of BMD by DXA scan and taking active interventions aim to SMA children with different types are important.

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