A simple method to prepare superhydrophobic polypropylene coatings for biomedical applications

2014 ◽  
Vol 7 (3/4) ◽  
pp. 156 ◽  
Author(s):  
Rafik Abbas ◽  
Wagih A. Sadik ◽  
Abdel Ghaffar M. El Demerdash ◽  
Adel F. Badria
Keyword(s):  
Biomedical Applications ◽  
Simple Method

Formability of Hydroxyapatite on Beta-Type Ti-Nb-Ta-Zr Alloy for Biomedical Applications through Alkaline Treatment Process

2007 ◽  
Vol 352 ◽  
pp. 297-300
Author(s):  
Toshikazu Akahori ◽  
Mitsuo Niinomi ◽  
Masaaki Nakai
Keyword(s):  
Alkaline Solution ◽  
Biomedical Applications ◽  
Treatment Process ◽  
Solution Treatment ◽  
Sodium Titanate ◽  
Alkaline Treatment ◽  
Simple Method ◽  
Metallic Biomaterials ◽  
Naoh Solution ◽  
Bioactive Surface Modification

Titanium and its alloys have been widely used as biomaterials for hard tissue replacements because of their excellent mechanical properties and biocompatibility. However, the bonding between their surfaces and bone is not enough after implantation. The bioactive surface modification such as a hydroxyapatite (HAp) coating on their surfaces has been investigated. Recently, a simple method for forming HAp layer on the surfaces of titanium and its alloys has been developed. This method is called as alkaline treatment process. In this method, HAp deposits on the surfaces of titanium and its alloys by dipping into simulated body fluid (SBF) after an alkaline solution treatment that is followed by a baking treatment (alkaline treatment). This process is applicable to newly developed beta-type Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) for biomedical applications achieving bioactive HAp modification. In this study, the morphology of the HAp layer formed on the surface of TNTZ was investigated after various alkaline treatments followed by dipping in SBF. The formability of HAp on the surface of TNTZ was then discussed. The formability of HAp on TNTZ is much lower than that of commercially pure Ti, Ti-6Al-4V ELI and Ti-15Mo-5Zr-3Al alloys, which are representative metallic biomaterials. The formability of HAp on TNTZ is improved by increasing the amount of Na in the sodium titanate gels formed during an alkaline solution treatment where the NaOH concentrations and the dipping time are over 5 M and 172.8 ks, respectively. The formability of HAp on TNTZ is considerably improved by dipping in a 5 M NaOH solution for 172.8 ks. This condition for alkaline solution treatment process is the most suitable for TNTZ.

scholarly journals Green fabrication of Co and Co3O4 nanoparticles and their biomedical applications: A review

2021 ◽  
Vol 16 (1) ◽  
pp. 14-30
Author(s):  
Abdul Waris ◽  
Misbahud Din ◽  
Asmat Ali ◽  
Shakeeb Afridi ◽  
Abdul Baset ◽  
...  
Keyword(s):  
Cobalt Oxide ◽  
Environmental Remediation ◽  
Biomedical Applications ◽  
High Surface ◽  
Volume Ratio ◽  
Lithium Ion ◽  
High Energy ◽  
Co3o4 Nanoparticles ◽  
Simple Method ◽  
Cobalt Oxide Nanoparticles

Abstract Nanotechnology is the fabrication, characterization, and potential application of various materials at the nanoscale. Over the past few decades, nanomaterials have attracted researchers from different fields because of their high surface-to-volume ratio and other unique and remarkable properties. Cobalt and cobalt oxide nanoparticles (NPs) have various biomedical applications because of their distinctive antioxidant, antimicrobial, antifungal, anticancer, larvicidal, antileishmanial, anticholinergic, wound healing, and antidiabetic properties. In addition to biomedical applications, cobalt and cobalt oxide NPs have been widely used in lithium-ion batteries, pigments and dyes, electronic thin film, capacitors, gas sensors, heterogeneous catalysis, and for environmental remediation purposes. Different chemical and physical approaches have been used to synthesize cobalt and cobalt oxide NPs; however, these methods could be associated with eco-toxicity, cost-effectiveness, high energy, and time consumption. Recently, an eco-friendly, safe, easy, and simple method has been developed by researchers, which uses biotic resources such as plant extract, microorganisms, algae, and other biomolecules such as starch and gelatin. Such biogenic cobalt and cobalt oxide NPs offer more advantages over other physicochemically synthesized methods. In this review, we have summarized the recent literature for the understanding of green synthesis of cobalt and cobalt oxide NPs, their characterization, and various biomedical applications.

scholarly journals Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review

2018 ◽  
Vol 15 (3) ◽  
pp. 679-685 ◽  
Author(s):  
Ranjith Ramanujam ◽  
Balraj Sundaram ◽  
Ganesh Janarthanan ◽  
Elamparithi Devendran ◽  
Moorthy Venkadasalam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carrier ◽  
Short Review ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Simple Method ◽  
Nanoprecipitation Method

Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.

scholarly journals Eu3 + doped hydroxyapatite as a fluorescent material for biomedical applications

2019 ◽  
Vol 1 (1) ◽  
pp. 56-57
Keyword(s):  
Contrast Agent ◽  
Biomedical Applications ◽  
Fluorescent Microscopy ◽  
Luminescent Properties ◽  
Point Of View ◽  
Simple Method ◽  
Fluorescent Material ◽  
Physico Chemical ◽  
Biocompatibility Test ◽  
Mineralogical Phase

The present study is based on obtaining a contrast agent but improved with a mineralogical phase for hard tissue medical imaging. In this sense, Eu3 + is used for the contrast agent part, because of the luminescent properties and for the action part on bone regeneration the hydroxyapatite is used. The obtained mix focuses on the promotion of information regarding the development of new bone tissue, which is evidenced by the luminescent Eu3 +. Using a simple method of synthesis, it was obtained a luminescent europium-doped nanohydroxyapatite which was characterized by physico-chemical and biological point of view. With the SEM, TEM and XRD equipment’s the morphological and structural properties were analyzed. Also, to evaluate the luminescent features of the obtained material it was subjected to the UV-Vis and photoluminescence (PL) spectra. Because of the fact that the material has application in medical investigation and not only, it was performed a biocompatibility test (MTT assay) and fluorescent microscopy. The results can be a promising start due to its characteristics, in such manner the Eu3 + doped hydroxyapatite can be used as a fluorescent material for biomedical applications [1].

scholarly journals Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes

Nanoscale ◽  
2018 ◽  
Vol 10 (16) ◽  
pp. 7711-7718 ◽  
Author(s):  
Hai Le-The ◽  
Martijn Tibbe ◽  
Joshua Loessberg-Zahl ◽  
Marciano Palma do Carmo ◽  
Marinke van der Helm ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Large Scale ◽  
Free Standing ◽  
Simple Method ◽  
Through Hole

A robust and simple method was developed for large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes for biomedical applications.

scholarly journals Titanium-Hydroxyapatite Composites Sintered at Low Temperature for Tissue Engineering: In vitro Cell Support and Biocompatibility

2017 ◽  
Vol 15 (2) ◽  
pp. 176-183 ◽  
Author(s):  
Romina Comín ◽  
Mariana P. Cid ◽  
Luciano Grinschpun ◽  
Carlos Oldani ◽  
Nancy A. Salvatierra
Keyword(s):  
Powder Metallurgy ◽  
Cell Morphology ◽  
Biomedical Applications ◽  
Metallic Matrix ◽  
Tissue Loss ◽  
Simple Method ◽  
Nih3t3 Cells ◽  
Composite Surface ◽  
Hydroxyapatite Composite

Background In clinical orthopedics, a critical problem is the bone tissue loss produced by a disease or injury. The use of composites from titanium and hydroxyapatite for biomedical applications has increased due to the resulting advantageous combination of hydroxyapatite bioactivity and favorable mechanical properties of titanium. Powder metallurgy is a simple and lower-cost method that uses powder from titanium and hydroxyapatite to obtain composites having hydroxyapatite phases in a metallic matrix. However, this method has certain limitations arising from thermal decomposition of hydroxyapatite in the titanium-hydroxyapatite system above 800°C. We obtained a composite from titanium and bovine hydroxyapatite powders sintered at 800°C and evaluated its bioactivity and cytocompatibility according to the ISO 10993 standard. Methods Surface analysis and bioactivity of the composite was evaluated by X-ray diffraction and SEM. MTT assay was carried out to assess cytotoxicity on Vero and NIH3T3 cells. Cell morphology and cell adhesion on the composite surface were analyzed using fluorescence and SEM. Results We obtained a porous composite with hydroxyapatite particles well integrated in titanium matrix which presented excellent bioactivity. Our data did not reveal any toxicity of titanium-hydroxyapatite composite on Vero or NIH3T3 cells. Moreover, extracts from composite did not affect cell morphology or density. Finally, NIH3T3 cells were capable of adhering to and proliferating on the composite surface. Conclusions The composite obtained displayed promising biomedical applications through the simple method of powder metallurgy. Additionally, these findings provide an in vitro proof for adequate biocompatibility of titanium-hydroxyapatite composite sintered at 800°C.

scholarly journals Biocompatibility Evaluation and Enhancement of Elastomeric Coatings Made Using Table-top Optical 3D Printer

2020 ◽  
Author(s):  
Giedrė Grigalevičiūtė ◽  
Daiva Baltriukienė ◽  
Virginija Bukelskienė ◽  
Mangirdas Malinauskas
Keyword(s):  
Stem Cells ◽  
Biomedical Applications ◽  
Live Cells ◽  
3D Printer ◽  
Polymerization Degree ◽  
Post Processing ◽  
Simple Method ◽  
Commercial Resin ◽  
Myogenic Stem Cells ◽  
3D Printed

In this experimental report the biocompatibility of elastomeric scaffold structures made via stereolithography employing table-top 3D printer (Ember, Autodesk) and commercial resin FormLabs Flexible (FormLabs) was studied. The samples were manufactured using standard printing and development protocol, which is known to inherit cytotoxicity due to remaining non-polymerized remaining monomers, despite the polymerized material being fully biocompatible. Additional steps were taken to remedy this problem: the fabricated structures were soaked in isopropanol and methanol for different conditions (temperature, duration) in order to leach out the non-polymerized monomers. Also printed structures were UV exposed to assure maximum polymerization degree of the material. Post-processed structures were seeded with myogenic stem cells and the number of live cells was evaluated as an indicator for the material biocompatibility. The straightforward post-processing protocol enhances the biocompatibility by 7 times after 7 days soaking in isopropanol and methanol and is comparable to control (glass and polystyrene) samples. This proposes the approach as a novel and simple method to be widely applicable for dramatic cytotoxicity reduction of optically 3D printed micro-/nano-scaffolds for biomedical applications.

Bi-Axial Stretchable Electrode Based on the Thin PDMS Substrate for the Biomedical Applications

2007 ◽  
Vol 544-545 ◽  
pp. 665-668 ◽  
Author(s):  
Ju Yeoul Baek ◽  
Gu Han Kwon ◽  
Jin Hee An ◽  
Ho Jung Chang ◽  
Ky Am Lee ◽  
...  
Keyword(s):  
Electrical Property ◽  
Biomedical Applications ◽  
Metal Layer ◽  
Soft Material ◽  
Artificial Skin ◽  
Pdms Layer ◽  
Pdms Substrate ◽  
Simple Method ◽  
Stretchable Electrode ◽  
Biomedical Fields

PDMS(polydimethylsiloxane) is a flexible and biocompatible material and is widely used in bio- or medical-related fields. In this paper, we have developed the soft electrode to be stretchable bi-axially by using tissue-like soft material (PDMS). We have established the simple method to deposit the metal layer on the PDMS layer to be stretchable bi-axially and we have evaluated the electrical property according to the application of bi-directional stresses. This stretchable electrode can be extensively utilized in biomedical fields such as implantable electrode and wire at the flexion region or artificial skin.

A simple way for producing holographic filters suitable for image improvement

1978 ◽  
Vol 36 (1) ◽  
pp. 226-227
Author(s):  
K.-H. Herrmann ◽  
E. Reuber ◽  
P. Schiske
Keyword(s):  
Transfer Functions ◽  
Diffraction Order ◽  
Lateral Position ◽  
Simple Method ◽  
Spatial Frequencies ◽  
Resolution Electron ◽  
Wiener Filters ◽  
Image Improvement ◽  
Optical Reconstruction ◽  
Set Up

Aposteriori deblurring of high resolution electron micrographs of weak phase objects can be performed by holographic filters [1,2] which are arranged in the Fourier domain of a light-optical reconstruction set-up. According to the diffraction efficiency and the lateral position of the grating structure, the filters permit adjustment of the amplitudes and phases of the spatial frequencies in the image which is obtained in the first diffraction order.In the case of bright field imaging with axial illumination, the Contrast Transfer Functions (CTF) are oscillating, but real. For different imageforming conditions and several signal-to-noise ratios an extensive set of Wiener-filters should be available. A simple method of producing such filters by only photographic and mechanical means will be described here.A transparent master grating with 6.25 lines/mm and 160 mm diameter was produced by a high precision computer plotter. It is photographed through a rotating mask, plotted by a standard plotter.

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