Effect of low doses and low dose-rates of gamma radiation on DNA damage in human peripheral blood leukocytes using comet assay

2006 ◽  
Vol 2 (1/2) ◽  
pp. 71 ◽  
Author(s):  
R.C. Chaubey ◽  
H.N. Bhilwade ◽  
R. Rajagopalan ◽  
V.R. Sonawane
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Gamma Radiation ◽  
Peripheral Blood ◽  
Low Dose ◽  
Human Peripheral Blood ◽  
Low Doses ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Dose Rates

Genotoxicity of gliotoxin on epithelial (A549, Hep G-2, CHO), monocyte (THP-1) cell lines and human peripheral blood leukocytes using alkaline comet assay

2006 ◽  
Vol 164 ◽  
pp. S285
Author(s):  
Ivan Kosalec ◽  
Nevenka Kopjar ◽  
Snježana Ramić ◽  
Stjepan Pepeljnjak ◽  
Višnja Bačun-Družina ◽  
...  
Keyword(s):  
Comet Assay ◽  
Cell Lines ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Alkaline Comet Assay ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes

scholarly journals Antigenotoxic properties of anthocyanin-enriched fraction of strawberry (cv. Romina) extract on DNA damage induced by H2O2 in human peripheral blood leukocytes

2021 ◽  
Vol 71 (3) ◽  
pp. 197-206
Author(s):  
Biljana Spremo-Potparević ◽  
Andrea Čabarkapa-Pirković ◽  
Dragana Dekanski ◽  
Dijana Topalović ◽  
Vladan Bajić ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Oxidative Dna Damage ◽  
Human Peripheral Blood ◽  
Antioxidant Properties ◽  
Protective Agent ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Damage Reduction

Strawberry fruit Fragaria × ananassa Duchesne, Rosaceae (cv. Romina), rich in anthocyanin polyphenols, has been demonstrated to have favorable effects on health due to its antioxidant properties. The present study investigated the antigenotoxic potential of anthocyanin enriched fraction of Romina strawberry methanolic extract (ACY) against DNA damage on human peripheral blood leukocytes, induced by hydrogen peroxide in vitro. Five concentrations of the ACY extract were used in all experiments (2.5, 5, 10, 15, 20 µg/ml). The results of the alkaline comet assay showed no genotoxic effect of the ACY. After the pre-exposure of the leukocytes to the ACY, and subsequent incubation with H2O2, a decreased number of DNA damaged cells was recorded in all the tested concentrations, compared to controls. In the posttreatment, there was a concentration-dependent DNA damage reduction, while a statistically significant decrease was achieved with 15 and 20 µg/ml concentrations. The results indicate that ACY is efficient in oxidative DNA damage reduction, and it is more potent as a post-applicative than a protective agent.

DETECTION OF DNA DAMAGE IN MOUSE PERIPHERAL BLOOD LEUKOCYTES BY THE COMET ASSAY AFTER ORAL ADMINISTRATION OF MONOCROTOPHOS

2002 ◽  
Vol 25 (1) ◽  
pp. 65-74 ◽  
Author(s):  
M. Mahboob ◽  
M. F. Rahman ◽  
K. Danadevi ◽  
B. Saleha Banu ◽  
Paramjit Grover
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Oral Administration ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes
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