scholarly journals Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study

2017 ◽  
Vol 42 (3) ◽  
pp. 172-180 ◽  
Author(s):  
Joseph J. Shenker ◽  
Sarojini M. Sengupta ◽  
Ridha Joober ◽  
Ashok Malla ◽  
M. Mallar Chakravarty ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Negative Symptoms ◽  
Risk Gene ◽  
Neuroimaging Genetics ◽  
Disorder Risk

No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes

2013 ◽  
Vol 151 (1) ◽  
pp. 291-297 ◽  
Author(s):  
Martin Tesli ◽  
Randi Egeland ◽  
Ida E. Sønderby ◽  
Unn K. Haukvik ◽  
Francesco Bettella ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gene Variants ◽  
Risk Gene ◽  
Disorder Risk

Effects of glutathione S-transferase M1 andT1 deletions on bipolar disorder risk among a Tunisian population

Gene ◽  
2017 ◽  
Vol 607 ◽  
pp. 31-35 ◽  
Author(s):  
Chahra Chbili ◽  
Ahlem Elouaer ◽  
Neila Fathallah ◽  
Manel Nouira ◽  
Besma Bel Hadj Jrad ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Tunisian Population ◽  
Glutathione S Transferase ◽  
Disorder Risk

scholarly journals Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes

Neuroscience ◽  
2010 ◽  
Vol 168 (3) ◽  
pp. 797-810 ◽  
Author(s):  
K.L. Eagleson ◽  
M.C. Gravielle ◽  
L.J. Schlueter McFadyen-Ketchum ◽  
S.J. Russek ◽  
D.H. Farb ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gabaa Receptor ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Receptor Subunit ◽  
Risk Gene ◽  
Autism Spectrum Disorder Risk ◽  
Disorder Risk

Association of hysterectomy with bipolar disorder risk: A population‐based cohort study

2019 ◽  
Vol 36 (6) ◽  
pp. 543-551 ◽  
Author(s):  
Yu‐Chih Shen ◽  
Weishan Chen ◽  
I‐Ju Tsai ◽  
Jen‐Hung Wang ◽  
Shinn‐Zong Lin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cohort Study ◽  
Population Based ◽  
Disorder Risk

Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder

2020 ◽  
Vol 25 (11) ◽  
pp. 2672-2684 ◽  
Author(s):  
Qingtuan Meng ◽  
Le Wang ◽  
Rujia Dai ◽  
Jiawen Wang ◽  
Zongyao Ren ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Gene ◽  
Integrative Analyses

Epidemiology and pathobiology of bipolar disorder, and their exploration within a complete catchment area population

2000 ◽  
Vol 12 (3) ◽  
pp. 73-76 ◽  
Author(s):  
P.J. Scully ◽  
J.M. Owens ◽  
A. Kinsella ◽  
J.L. Waddington
Keyword(s):  
Bipolar Disorder ◽  
Life Events ◽  
Catchment Area ◽  
Negative Symptoms ◽  
Age At Onset ◽  
Later Life ◽  
Positive Symptoms ◽  
Left Hand ◽  
Duration Of Illness

ABSTRACTEpidemiological and pathobiological findings in bipolar disorder [BP] have often been limited by selection bias and lack of epidemiological representativeness. In a rural, circumscribed catchment area, ‘all’ patients with BP were identified and assessed. On preliminary analysis, morbid risk [MR] for BP over the area as a whole was 5.0 ± 0.6/1000. The distribution of MR for BP over geographical subregions showed no significant deviation from a statistical model for random occurrences in space by place at birth, in contrast to schizophrenia [SZ], and varied only modestly among males by place at onset. These results imply different etiological factors acting in BP in comparison with SZ, particularly with regard to the role of early versus later life events. In preliminary analyses of psychotic and cognitive features, current severity of positive symptoms was predicted in BP only by increasing dominance of the left hand; negative symptoms by duration of illness and current anticholinergic exposure; poorer general and frontal cognitive function by older age at onset of illness, increasing duration of illness, and current anticholinergic exposure. The finding on handedness suggests disturbance of cerebral asymmetry associated with positive symptoms in BP, while both negative symptoms and cognitive impairment may involve progressive processes. Further analysis of this epidemiologically complete population, including systematic comparisons of BP with schizoaffective disorder and SZ, continues.

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